scholarly journals Corrigendum to “Chronic retinal injury induced by white LED light with different correlated color temperatures as determined by microarray analyses of genome-wide expression patterns in mice” Journal of Photochemistry & Photobiology, B: Biology 2020 Sep;210:111977

Author(s):  
Chen Xie ◽  
Hong Zhu ◽  
Shuyang Chen ◽  
Yingying Wen ◽  
Le Jin ◽  
...  
2007 ◽  
Vol 6 (1) ◽  
pp. 79 ◽  
Author(s):  
Eike Staub ◽  
Joern Groene ◽  
Maya Heinze ◽  
Detlev Mennerich ◽  
Stefan Roepcke ◽  
...  

2006 ◽  
Vol 72 (10) ◽  
pp. 6607-6614 ◽  
Author(s):  
J. Jacob Parnell ◽  
Joonhong Park ◽  
Vincent Denef ◽  
Tamara Tsoi ◽  
Syed Hashsham ◽  
...  

ABSTRACT The biodegradation of polychlorinated biphenyls (PCBs) relies on the ability of aerobic microorganisms such as Burkholderia xenovorans sp. LB400 to tolerate two potential modes of toxicity presented by PCB degradation: passive toxicity, as hydrophobic PCBs potentially disrupt membrane and protein function, and degradation-dependent toxicity from intermediates of incomplete degradation. We monitored the physiological characteristics and genome-wide expression patterns of LB400 in response to the presence of Aroclor 1242 (500 ppm) under low expression of the structural biphenyl pathway (succinate and benzoate growth) and under induction by biphenyl. We found no inhibition of growth or change in fatty acid profile due to PCBs under nondegrading conditions. Moreover, we observed no differential gene expression due to PCBs themselves. However, PCBs did have a slight effect on the biosurface area of LB400 cells and caused slight membrane separation. Upon activation of the biphenyl pathway, we found growth inhibition from PCBs beginning after exponential-phase growth suggestive of the accumulation of toxic compounds. Genome-wide expression profiling revealed 47 differentially expressed genes (0.56% of all genes) under these conditions. The biphenyl and catechol pathways were induced as expected, but the quinoprotein methanol metabolic pathway and a putative chloroacetaldehyde dehydrogenase were also highly expressed. As the latter protein is essential to conversion of toxic metabolites in dichloroethane degradation, it may play a similar role in the degradation of chlorinated aliphatic compounds resulting from PCB degradation.


BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 503 ◽  
Author(s):  
Heather A Adams ◽  
Bruce R Southey ◽  
Gene E Robinson ◽  
Sandra L Rodriguez-Zas

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Min-A Seol ◽  
In-Sun Chu ◽  
Mi-Jin Lee ◽  
Goung-Ran Yu ◽  
Xiang-Dan Cui ◽  
...  

2004 ◽  
Vol 279 (19) ◽  
pp. 20327-20338 ◽  
Author(s):  
Catherine D. Carrillo ◽  
Eduardo Taboada ◽  
John H. E. Nash ◽  
Patricia Lanthier ◽  
John Kelly ◽  
...  

We examined two variants of the genome-sequenced strain,Campylobacter jejuniNCTC11168, which show marked differences in their virulence properties including colonization of poultry, invasion of Caco-2 cells, and motility. Transcript profiles obtained from whole genome DNA microarrays and proteome analyses demonstrated that these differences are reflected in late flagellar structural components and in virulence factors including those involved in flagellar glycosylation and cytolethal distending toxin production. We identified putative σ28and σ54promoters for many of the affected genes and found that greater differences in expression were observed for σ28-controlled genes. Inactivation of the gene encoding σ28,fliA, resulted in an unexpected increase in transcripts with σ54promoters, as well as decreased transcription of σ28-regulated genes. This was unlike the transcription profile observed for the attenuatedC. jejunivariant, suggesting that the reduced virulence of this organism was not entirely due to impaired function of σ28. However, inactivation offlhA, an important component of the flagellar export apparatus, resulted in expression patterns similar to that of the attenuated variant. These findings indicate that the flagellar regulatory system plays an important role in campylobacter pathogenesis and thatflhAis a key element involved in the coordinate regulation of late flagellar genes and of virulence factors inC. jejuni.


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