Vital exhaustion and risk of alcohol use disorders: A prospective cohort study

2018 ◽  
Vol 114 ◽  
pp. 25-30
Author(s):  
Emilie Just-Østergaard ◽  
Erik L. Mortensen ◽  
Janne S. Tolstrup ◽  
Trine Flensborg-Madsen
2014 ◽  
Vol 22 (10) ◽  
pp. 1047-1054 ◽  
Author(s):  
Elżbieta Kuźma ◽  
David J. Llewellyn ◽  
Kenneth M. Langa ◽  
Robert B. Wallace ◽  
Iain A. Lang

Addiction ◽  
2017 ◽  
Vol 113 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Emilie Just-Østergaard ◽  
Erik L. Mortensen ◽  
Trine Flensborg-Madsen

2014 ◽  
Vol 50 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Louise Kristiansen Ejsing ◽  
Ulrik Becker ◽  
Janne S. Tolstrup ◽  
Trine Flensborg-Madsen

2008 ◽  
Vol 69 (3) ◽  
pp. 371-377 ◽  
Author(s):  
Trine Flensborg-Madsen ◽  
Joachim Knop ◽  
Erik Lykke Mortensen ◽  
Ulrik Becker ◽  
Nita Makhija ◽  
...  

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e028997
Author(s):  
Emilie Just-Østergaard ◽  
Trine Flensborg-Madsen ◽  
Joachim Knop ◽  
Holger Jelling Sørensen ◽  
Ulrik Becker ◽  
...  

ObjectivesThe aims were to estimate the association between intelligence measured in young adulthood and risk of alcohol use disorders (AUD) in men and to investigate the potential modification of this association by psychiatric disorders, parental AUD and parental psychiatric disorders.DesignProspective cohort study based on a linkage of intelligence test scores from draft board examinations and register data on AUD diagnoses during 36 years of follow-up.SettingDenmark.Participants3287 Danish men from the Copenhagen Perinatal Cohort (born 1959–1961) who appeared before the draft board at a mean age of 18.7 years.Primary outcome measureFirst registration with AUD during follow-up was the primary outcome. Information on AUD was based on diagnoses retrieved from national hospital and outpatient treatment registers, defined according to the International Classification of Diseases.Results361 (11.0%) men were registered with AUD during follow-up. Low intelligence scores were associated with increased odds of AUD adjusting for parental AUD, parental psychiatric disorders, maternal smoking during pregnancy, birth weight, maternal age at birth, parity and childhood socioeconomic position (OR per SD decrease in intelligence=1.69, 95% CI 1.49 to 1.92). Separate analyses indicated significant interaction (p<0.001) between intelligence and psychiatric disorders. The adjusted OR per SD decrease in intelligence score was 2.04 (95% CI 1.67 to 2.49) in men without other psychiatric disorders whereas the OR was 1.21 (95% CI 1.01 to 1.46) in men with other psychiatric disorders. No interaction was found between intelligence and parental AUD or between intelligence and parental psychiatric disorders.ConclusionsThe association between intelligence in young adulthood and AUD is modified by other psychiatric disorders as low intelligence is primarily a risk factor for men without other psychiatric disorders. Future studies should take other psychiatric disorders into account when investigating associations between intelligence and AUD.


2019 ◽  
Vol 29 (4) ◽  
pp. 736-740 ◽  
Author(s):  
Sonia Sharmin ◽  
Kypros Kypri ◽  
Monika Wadolowski ◽  
Raimondo Bruno ◽  
Masuma Khanam ◽  
...  

Abstract Background Why adolescents’ drinking is associated with their parents’ drinking remains unclear. We examined associations in a prospective cohort study, adjusting for socio-demographic characteristics and family factors. Methods We recruited 1927 children from grade 7 classes (mean age 13 years), and one of their parents, in three Australian states, contacted participants annually from 2010 to 2014, and analysed data from assessments at ages 13, 14, 15 and 16 years. We used the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) subscale to identify hazardous drinking in parents (score ≥5) and children (score ≥3) and constructed mixed-effect logistic regression models, accounting for clustering within school and adjusting for likely confounders. We evaluated the sensitivity of estimates by imputing missing values assuming the data were missing at random vs. missing not at random. Results Parent hazardous drinking predicted mid-adolescent hazardous drinking, e.g. 15 years olds whose parents [adjusted odds ratio (aOR) 2.00; 95% confidence interval 1.51–2.64] or parents’ partners (aOR 1.94; 1.48–2.55) were hazardous drinkers had higher odds of being hazardous drinkers at age 16. The magnitude of univariate associations changed little after adjusting for covariates, and sensitivity analyses confirmed the robustness of the association, across a wide range of assumptions about the missing data. Conclusions The associations between parents’ and their adolescent children’s hazardous drinking are unlikely to be due to confounding by socio-demographic and family factors. Parents should be encouraged, and supported by public policy, to reduce their own alcohol consumption in order to reduce their children’s risk of becoming hazardous drinkers.


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