scholarly journals The impact of research grant funding on scientific productivity

2011 ◽  
Vol 95 (9-10) ◽  
pp. 1168-1177 ◽  
Author(s):  
Brian A. Jacob ◽  
Lars Lefgren
Keyword(s):  
Scientific Productivity ◽  
Grant Funding ◽  
The Impact ◽  
Research Grant

Developing a methodology to assess the impact of research grant funding: A mixed methods approach

2014 ◽  
Vol 43 ◽  
pp. 105-117 ◽  
Author(s):  
Carter Bloch ◽  
Mads P. Sørensen ◽  
Ebbe K. Graversen ◽  
Jesper W. Schneider ◽  
Evanthia Kalpazidou Schmidt ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Grant Funding ◽  
Mixed Methods Approach ◽  
The Impact ◽  
Research Grant

scholarly journals POS0293 TRheuMa REGISTRY PROVIDES FIRST EVIDENCE OF DIFFERENT COURSE OF RHEUMATIC IMMUNE-RELATED ADVERSE EVENTS AND TUMOUR RESPONSE RATES DEPENDING ON THE TUMOUR ENTITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 372.3-372
Author(s):  
L. Diekmann ◽  
L. Daniello ◽  
J. Kunz ◽  
J. Leipe ◽  
H. M. Lorenz ◽  
...  
Keyword(s):  
Tumour Response ◽  
Research Support ◽  
Grant Funding ◽  
Real World Data ◽  
Underlying Malignancy ◽  
Tumour Entity ◽  
Melanoma Patients ◽  
Funding Institution ◽  
Nsclc Patients ◽  
Research Grant

Background:Rheumatic immune-related adverse events (irAE) are associated with a better tumour response to immune checkpoint inhibitors (ICI). In contrast to other irAEs, their potentially chronic course may require long-term immunosuppressive treatment.Objectives:Our registry-based study analyses real-world data on the characteristics and outcome of rheumatic irAEs and underlying malignancy. Herein, we present first evidence that these parameters and the optimal clinical management may differ depending on the tumour entity.Methods:The TRheuMa registry is a prospective long-term observational study of a patient cohort suffering from rheumatic side effects of cancer therapies with focus on ICI. It is part of the MalheuR project initiated in July 2018 at the University Hospital Heidelberg to explore interrelations of malignancies and RMDs.Results:64 patients were recruited due to a rheumatic irAE under ICI treatment (nivolumab n=30, pembrolizumab n=33, ipilimumab n=12, PD-L1i n=5, ipi/nivo n=10) with a follow-up of up to 30 months. Of these, 47% had NSCLC and 41% melanoma. In local cohorts of patients receiving ICI, 4% of NSCLC (n total=888) and 13% of melanoma (n total=195) developed a rheumatic irAE. 7% of NSCLC and 23% of melanoma patients experienced a flare of a pre-existing RMD. De novo irAE mostly resembled phenotypes of spondyloarthritis both in NSCLC (43%) as well as in melanoma patients (33%). CRP levels were increased in 83% of NSCLC and 71% of melanoma patients. Almost all irAE patients showed autoantibody negativity and signs of inflammation in ultrasound examination (96%). Comparison of best responses to treatment in patients with and without rheumatic irAE in melanoma and without any irAE in NSCLC patients were as following: Complete remission (CR) in 48% vs. 4% of melanoma patients and partial remission (PR) in 68% vs. 41% of NSCLC patients. In accordance with our severity-based treatment algorithm, 25% of the melanoma patients in CR and 16% of the NSCLC patients in PR needed add-on DMARDs for sufficient irAE-treatment. ICI-treatment was discontinued in 7 cases (17% NSCLC, 8% melanoma)Conclusion:Prospective real-world data from the TRheuMa-registry provide first evidence that rheumatic irAE have distinct characteristics depending on the underlying malignancy. Oncological outcome was better with rheumatic irAE than in their absence and this effect was more pronounced in melanoma patients despite a larger use of immunosuppressants for irAE-treatment.Disclosure of Interests:Leonore Diekmann: None declared, Lea Daniello: None declared, Julia Kunz: None declared, Jan Leipe Consultant of: Pfizer; Novartis; Honoraria (self), Abbvie; Astra Zeneca; BMS; Celgene; Hospira; Janssen-Cilag; Gilead; LEO Pharma; Lilly; MSD; Roche; Sanofi; UCB., Grant/research support from: Research grant/Funding (self): Pfizer; Novartis; Honoraria (self), Hanns-Martin Lorenz Consultant of: Abbvie; BMS; MSD; Pfizer; Celgene; Roche; Chugai; Medac; GSK; Honoraria (self), Novartis; UCB; Janssen-Cilag; Astra Zeneca; Lilly, Grant/research support from: Research grant/Funding (institution): Abbvie; BMS; MSD; Pfizer; Celgene; Roche; Chugai; Medac; GSK; Honoraria (self), Research grant/Funding (institution), Novartis; UCB; Janssen-Cilag; Astra Zeneca; Lilly; Research grant/Funding (institution): Baxter; SOBI; Biogen; Actelion; Mundipharma; Bayer Vital; Octapharm; Sanofi; Hexal; Thermo Fischer; Shire., Jessica Hassel Consultant of: MDS; Honoraria (self): Roche; Novartis; Pierre Fabre., Grant/research support from: BMS; Honoraria (self), Karin Jordan Consultant of: Advisory/Consultancy: Amgen; Merck; MSD; Riemser; Helsinn; Tesaro; Kreussler; Voluntis; Pfizer; Pomme-med; Hexal., Petros Christopoulos Consultant of: advisory board/lecture fees from AstraZeneca, Boehringer Ingelheim, Chugai, Novartis, Pfizer, Roche, Takeda., Grant/research support from: research funding from AstraZeneca, Novartis, Roche, Takeda, Karolina Benesova Grant/research support from: Foundations and Awards” commission of the University of Heidelberg: University of Heidelberg; AbbVie; Novartis; Rheumaliga Baden-Württemberg e.V

scholarly journals Spanish communication academia: Scientific productivity vs. Social activity

Comunicar ◽  
2013 ◽  
Vol 21 (41) ◽  
pp. 61-70 ◽  
Author(s):  
Cristóbal Casanueva-Rocha ◽  
Francisco-Javier Caro-González
Keyword(s):  
Social Network ◽  
Social Factors ◽  
Social Activity ◽  
Scientific Productivity ◽  
Scientific Activity ◽  
Redes Sociales ◽  
International Scope ◽  
The Social ◽  
La Red ◽  
The Impact

At a time when academic activity in the area of communication is principally assessed by the impact of scientific journals, the scientific media and the scientific productivity of researchers, the question arises as to whether social factors condition scientific activity as much as these objective elements. This investigation analyzes the influence of scientific productivity and social activity in the area of communication. We identify a social network of researchers from a compilation of doctoral theses in communication and calculate the scientific production of 180 of the most active researchers who sit on doctoral committees. Social network analysis is then used to study the relations that are formed on these doctoral thesis committees. The results suggest that social factors, rather than individual scientific productivity, positively influence such a key academic and scientific activity as the award of doctoral degrees. Our conclusions point to a disconnection between scientific productivity and the international scope of researchers and their role in the social network. Nevertheless, the consequences of this situation are tempered by the nonhierarchical structure of relations between communication scientists. En un momento en que la actividad académica en el ámbito de la comunicación se valora principalmente por el impacto de las revistas y los medios de comunicación científica y por la productividad de los investigadores, surge la cuestión de si los factores sociales pueden condicionar la actividad científica con la misma fuerza que estos elementos objetivos. Esta investigación analiza la influencia de la productividad científica y de la actividad social en el ámbito de la comunicación. Se ha identificado la red social de los investigadores de comunicación a partir de las tesis doctorales. Para los 180 investigadores más activos en los tribunales de tesis se ha calculado su producción científica. Se utiliza el análisis de redes sociales para estudiar las relaciones que se producen en los tribunales de tesis doctorales. Los resultados muestran que los factores sociales influyen positivamente en una actividad académica y científica tan relevante como la obtención del grado de doctor, mientras que la productividad científica individual no lo hace. Como conclusiones cabe señalar que existe una desconexión entre la productividad científica y la proyección internacional de los investigadores y su papel en la red social. Las implicaciones de este hecho están matizadas por una estructura no jerarquizada de las relaciones entre los científicos de comunicación.

Publishing Productivity in Sport Psychology 1970–2000: An Exploratory Examination of the Lotka-Price Law

2003 ◽  
Vol 25 (4) ◽  
pp. 477-483 ◽  
Author(s):  
Joseph Baker ◽  
Jennifer Robertson-Wilson ◽  
Whitney Sedgwick
Keyword(s):  
Sport Psychology ◽  
Scientific Productivity ◽  
Eminent Scientist ◽  
Research Papers ◽  
Limited Support ◽  
The Impact ◽  
Published Research ◽  
Shed Light

The current study examined whether the distribution of published research papers in the field of sport psychology followed the Lotka-Price Law of scientific productivity. All authors who had published articles in five sport psychology journals from 1970 to 2000 were considered. The impact of those authors was determined by the total number of published papers in all journals. Results provided limited support for the Lotka-Price Law; however, it appeared that the field of sport psychology was less elitist than other fields. Although these findings suggest that productivity in this field is similar to that in other fields of science, more research is needed to shed light on the role of the eminent scientist and the average researcher in the advancement of knowledge in sport psychology.

scholarly journals Candida parapsilosis Candidemia Resistance Patterns and Treatment Outcomes: An Opportunity for Antifungal Stewardship

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S86-S86
Author(s):  
Gary Fong ◽  
Kim Ngo ◽  
Hannah Russo ◽  
Nicholas Beyda
Keyword(s):  
Combination Therapy ◽  
Treatment Outcomes ◽  
Candida Parapsilosis ◽  
Medical Center ◽  
Antifungal Susceptibility ◽  
Antifungal Stewardship ◽  
Resistance Patterns ◽  
Fluconazole Therapy ◽  
The Impact ◽  
Research Grant

Abstract Background Candida parapsilosis has emerged as an important fungal pathogen with mortality rates up to 30%. Recent studies show no difference in treatment outcomes for patients treated both empirically and definitively with either echinocandins or fluconazole. However, the impact of antifungal susceptibility testing and opportunities for antifungal stewardship are less clear in this patient population. The purpose of this study was to assess antifungal susceptibility rates, treatment patterns, and outcomes among patients with C. parapsilosis candidemia. Methods This was a single-center, retrospective cohort review of adult patients with a positive blood culture for C. parapsilosis hospitalized at Baylor St. Luke’s Medical Center, between 2006 and 2016. Patients with mixed or breakthrough candidemia were excluded as well as patients who expired within 3 days of candidemia onset. Results Eighty patients with C. parapsilosis candidemia were identified of which 48 met inclusion criteria. Nine patients had infections caused by fluconazole non-susceptible isolates (19%). The most common empiric treatment choice was an echinocandin (33/48, 69%), followed by fluconazole (9/48, 19%), and combination therapy (6/48, 13%). Of the 39 patients with fluconazole susceptible isolates, only 17 were treated with fluconazole definitively (44%). Among patients who received empiric echinocandin vs. fluconazole therapy, there was no difference in 14-day mortality (9% vs. 11%, P = 1.00) or in-hospital mortality (12% vs. 11%, P = 1.00). Empiric combination therapy was the only independent risk factor for treatment failure (OR, 13.8; 95% CI, 1.4–138.3; P = 0.03). Conclusion Treatment outcomes for patients receiving echinocandins were similar for those receiving fluconazole. At our institution, the increased incidence of fluconazole non-susceptible isolates warrants the use of echinocandins empirically. Patients were more likely to remain on echinocandin therapy even when fluconazole susceptible isolates were identified. This study reinforces the guideline suggestion that neither echinocandins nor fluconazole treatment leads to superior outcomes, but also identifies a cohort of patients in need of antifungal stewardship. Disclosures N. Beyda, Astellas: Grant Investigator and Scientific Advisor, Research grant

scholarly journals 2801. Post-Natal Zika Virus Infection and Impact on Neurodevelopment Among a Cohort of Children in Rural Guatemala

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S990-S991
Author(s):  
Daniel Olson ◽  
Molly Lamb ◽  
Amy Connery ◽  
Kathryn Colborn ◽  
Muktha S Natrajan ◽  
...  
Keyword(s):  
Zika Virus ◽  
Receptive Language ◽  
Fine Motor ◽  
Serum Samples ◽  
Zikv Infection ◽  
Related Factors ◽  
Material Support ◽  
And Gender ◽  
The Impact ◽  
Research Grant

Abstract Background The impact of early post-natal Zika virus (ZIKV) infection on neurodevelopment (ND) is unknown. A prospective study of post-natal ZIKV infection in rural Guatemala (ZIKV study) enrolled a cohort of children ages 1–5 years, including children previously enrolled in a dengue virus (DENV) study during the 2015–2016 ZIKV epidemic. We evaluated ND outcomes by age and ZIKV infection status. Methods Subjects enrolled in the ZIKV study June 2017–April 2018 underwent ND testing using the Mullen Scales of Early Learning (MSEL) at baseline and 12 months later. ZIKV/DENV-1/2 FRNT50 was performed on enrollment and on banked serum samples from the 2015 to 2016 subset. ZIKV serostatus and MSEL scores were correlated using multiple linear mixed models, adjusted for age and gender when appropriate, to evaluate their association. Geolocation was used to explore clustering of ZIKV serostatus and MSEL score. Results We enrolled 183 children (43% female, mean age 3.2 years). Of these, 38 (21%) were classified as ZIKV-positive (+), 111 (61%) ZIKV-negative (-), 31 (17%) ZIKV-possible, and 3 (2%) ZIKV-indeterminate. ZIKV(+) cases and higher composite MSEL scores clustered in more densely populated areas (Figure 1). ZIKV(+) serostatus was associated with higher MSEL composite (increase in log score 0.09, P = 0.003) and subdomain scores: fine motor (0.13, P = 0.011), visual reception (0.15, P = 0.002), receptive language (0.09, P = 0.041), gross motor (0.14, P = 0.09), and expressive language (0.09, P = 0.058) (Figure 2). Of the 78 children (43%) with 2015–2016 samples, 46 (59%) remained ZIKV(−), 16 (21%) seroconverted from ZIKV(−) or possible/indeterminate to ZIKV(+), and 16 (21%) were indeterminate when enrolled in the ZIKV study. ZIKV seroconversion was associated with higher composite (0.13, P = 0.02) MSEL scores compared with ZIKV(−). Conclusion In this exploratory analysis, post-natal ZIKV infection was not associated with adverse ND outcomes in children age 1–5 years. Overall, ZIKV(+) status was associated with higher average ND scores than ZIKV(−), and scores decreased with age for most children, independent of ZIKV status. The correlation of ZIKV(+) status and higher MSEL scores may be confounded by geographic-related factors or other confounders. NIAID Contract HHSN272201300015I Task Order HHSN27200013 (Co-PIs: FMM & EJA). Disclosures Flor M. Munoz, M.D, Biocryst: Grant/Research Support; CDC: Research Grant; Moderna: Other Financial or Material Support, Safety Monitoring Board Member/Chair; NIH: Research Grant; Novavax: Research Grant; UP to Date: Author and Editor - Royalties, Other Financial or Material Support.

A History of Drug and Alcohol Block Grant Funding and its Effects on Pennsylvania's Prevention Services System

1986 ◽  
Vol 16 (1) ◽  
pp. 13-25
Author(s):  
Philip M. Brown
Keyword(s):  
State Level ◽  
Block Grant ◽  
Regulatory Structure ◽  
Grant Funding ◽  
Decentralized System ◽  
Prevention Services ◽  
Services Delivery ◽  
History Of ◽  
The Impact ◽  
Drug And Alcohol

The impact of the U.S. Government's block grant fiscal policy on the funding policies and program services in drug and alcohol abuse prevention are examined. A case history of the Commonwealth of Pennsylvania's experience with block grant funding mandates is used to document the administrative and programmatic considerations affecting policy implementation at the state level. The conclusion is drawn that a strong, decentralized system with adequate management capability and regulatory structure was able to respond to the mandated changes and demonstrate increased prevention services delivery.

Sign in / Sign up

Export Citation Format

Share Document