POS0293 TRheuMa REGISTRY PROVIDES FIRST EVIDENCE OF DIFFERENT COURSE OF RHEUMATIC IMMUNE-RELATED ADVERSE EVENTS AND TUMOUR RESPONSE RATES DEPENDING ON THE TUMOUR ENTITY

Background:Rheumatic immune-related adverse events (irAE) are associated with a better tumour response to immune checkpoint inhibitors (ICI). In contrast to other irAEs, their potentially chronic course may require long-term immunosuppressive treatment.Objectives:Our registry-based study analyses real-world data on the characteristics and outcome of rheumatic irAEs and underlying malignancy. Herein, we present first evidence that these parameters and the optimal clinical management may differ depending on the tumour entity.Methods:The TRheuMa registry is a prospective long-term observational study of a patient cohort suffering from rheumatic side effects of cancer therapies with focus on ICI. It is part of the MalheuR project initiated in July 2018 at the University Hospital Heidelberg to explore interrelations of malignancies and RMDs.Results:64 patients were recruited due to a rheumatic irAE under ICI treatment (nivolumab n=30, pembrolizumab n=33, ipilimumab n=12, PD-L1i n=5, ipi/nivo n=10) with a follow-up of up to 30 months. Of these, 47% had NSCLC and 41% melanoma. In local cohorts of patients receiving ICI, 4% of NSCLC (n total=888) and 13% of melanoma (n total=195) developed a rheumatic irAE. 7% of NSCLC and 23% of melanoma patients experienced a flare of a pre-existing RMD. De novo irAE mostly resembled phenotypes of spondyloarthritis both in NSCLC (43%) as well as in melanoma patients (33%). CRP levels were increased in 83% of NSCLC and 71% of melanoma patients. Almost all irAE patients showed autoantibody negativity and signs of inflammation in ultrasound examination (96%). Comparison of best responses to treatment in patients with and without rheumatic irAE in melanoma and without any irAE in NSCLC patients were as following: Complete remission (CR) in 48% vs. 4% of melanoma patients and partial remission (PR) in 68% vs. 41% of NSCLC patients. In accordance with our severity-based treatment algorithm, 25% of the melanoma patients in CR and 16% of the NSCLC patients in PR needed add-on DMARDs for sufficient irAE-treatment. ICI-treatment was discontinued in 7 cases (17% NSCLC, 8% melanoma)Conclusion:Prospective real-world data from the TRheuMa-registry provide first evidence that rheumatic irAE have distinct characteristics depending on the underlying malignancy. Oncological outcome was better with rheumatic irAE than in their absence and this effect was more pronounced in melanoma patients despite a larger use of immunosuppressants for irAE-treatment.Disclosure of Interests:Leonore Diekmann: None declared, Lea Daniello: None declared, Julia Kunz: None declared, Jan Leipe Consultant of: Pfizer; Novartis; Honoraria (self), Abbvie; Astra Zeneca; BMS; Celgene; Hospira; Janssen-Cilag; Gilead; LEO Pharma; Lilly; MSD; Roche; Sanofi; UCB., Grant/research support from: Research grant/Funding (self): Pfizer; Novartis; Honoraria (self), Hanns-Martin Lorenz Consultant of: Abbvie; BMS; MSD; Pfizer; Celgene; Roche; Chugai; Medac; GSK; Honoraria (self), Novartis; UCB; Janssen-Cilag; Astra Zeneca; Lilly, Grant/research support from: Research grant/Funding (institution): Abbvie; BMS; MSD; Pfizer; Celgene; Roche; Chugai; Medac; GSK; Honoraria (self), Research grant/Funding (institution), Novartis; UCB; Janssen-Cilag; Astra Zeneca; Lilly; Research grant/Funding (institution): Baxter; SOBI; Biogen; Actelion; Mundipharma; Bayer Vital; Octapharm; Sanofi; Hexal; Thermo Fischer; Shire., Jessica Hassel Consultant of: MDS; Honoraria (self): Roche; Novartis; Pierre Fabre., Grant/research support from: BMS; Honoraria (self), Karin Jordan Consultant of: Advisory/Consultancy: Amgen; Merck; MSD; Riemser; Helsinn; Tesaro; Kreussler; Voluntis; Pfizer; Pomme-med; Hexal., Petros Christopoulos Consultant of: advisory board/lecture fees from AstraZeneca, Boehringer Ingelheim, Chugai, Novartis, Pfizer, Roche, Takeda., Grant/research support from: research funding from AstraZeneca, Novartis, Roche, Takeda, Karolina Benesova Grant/research support from: Foundations and Awards” commission of the University of Heidelberg: University of Heidelberg; AbbVie; Novartis; Rheumaliga Baden-Württemberg e.V

EXECUTIVE IMPLEMENTATION BY DEBT COLLECTOR AGAINST FIDUSIAN OBJECT GUARANTEE

Multi - finance institutions in Indonesia are better if the indicator is the number of consumer finance in Indonesia in the last few years. The growth of consumer financing can be seen from all the convenience given by the multi finance. The factor that dominates the forced withdrawal of Fiduciary Guarantee is the existence of problem loans. This problem is al most certainly experienced by any consumer financing institution. The problems discussed in this research are about how the implementation of execution of fiduciary guarantee in the settlement credit toward four wheels (car) The formulation of problems related to with the withdrawal of vehicles accompanied by violence that is: How about the collection of arrangement or confiscation of a motor vehicle that carried out by debt collector against a debtor non-performing loans, Do factors for the act of violence carried out by debt collector, How a settlement effort the act of violence carried out by debt collector in terms of the aspect of criminal law. This research is classified as the kind of research juridical normative , study legislation as criminal code and civil law, Regulation president of the Republic Indonesia No. 9 of 2009 about Funding Institution, the act of No. 42 of 1999 about Fiduciary Security, Minister of Finance Regulation No. 130/PMK.010/2012 about Registration Fiduciary for Financing Company, this research also is study case that is focus self intensively on an object particular and learn that as a case. Arrangement about the collection of vehicles stipulated in a financing with fiduciary security contained in the act of fiduciary security number 42 of 1999 And also minister of finance regulation No 130/PMK. 010/2012

Pelaksanaan Akta Pelepasan Hak Sebagai Alas Hak Untuk Mengajukan Permohonan Peralihan Dan Perubahan Hak Guna Bangunan Yang Jangka Waktunya Telah Berakhir Di Kabupaten Brebes

AbstrakTujuan utama yang akan dilaksanakan dalam penelitian ini adalah sebagai berikut : 1) Untuk menganalisis bagaimana pelaksanaan akta pelepasan hak sebagai alas hak untuk mengajukan permohonan peralihan dan perubahan hak guna bangunan yang jangka waktunya telah berakhir, 2) Untuk menganalisis kelemahan dan solusi pelaksanaan akta pelepasan hak sebagai alas hak untuk mengajukan permohonan peralihan dan perubahan hak guna bangunan yang jangka waktunya telah berakhir di Kabupaten Brebes.Penelitian ini bersifat Soci-Legal Research dimana dalam penelitian ini akan dipaparkan tentang pelaksanaan akta pelepasan hak untuk mengajukan permohonan peralihan dan perubahan hak guna bangunan yang telah berakhir jangka waktunya. Bersifat analistis, karena terhadap data yang diperoleh itu dilakukan analisis data secara kualitatif.Kesimpulan atas pelaksanaan akta pelepasan hak sebagai alas hak untuk mengajukan permohonan peralihan dan perubahan hak guna bangunan yang jangka waktunya telah berakhir yaitu dalam pelaksanaan akta pelepasan hak harus didukung dengan syarat-syarat yang lain disamping identitas pemohon, juga mengenai data yuridis atas tanah yang dimohon yaitu berupa bukti pelunasaan dari pihak bank sebagai lembaga yang membiayai, disamping itu akta pelepasan hak dapat dilaksanakan apabila sudah memenuhi syarat otentitas akta dan syarat sahnya suatu perjanjian yaitu akta pelepasan hak dapat dibuat setelah dikeluarkanya Surat Keterangan Pendaftaran Tanah (SKPT) dari Kantor Pertanahan setempat.Kata kunci : Akta Pelepasan Hak, alas hak, Hak Guna BangunanAbstractThe main objectives to be carried out in this research are as follows: 1) To analyze how the implementation of the deed of disposal of rights as the base of the right to apply for the transition and change of building rights which has expired, 2) To analyze the weaknesses and the implementation of the deed of disposal as a basis for the right to file transitional applications and changes in building rights that have expired in Brebes County.This research is Soci-Legal Research which in this research will be presented about the implementation of the deed of release of the right to apply for the transition and change of the right to the building which has expired the time period. Analytical, because of the data obtained was analyzed data qualitatively.The conclusion of the exercise of the deed of disposal of rights as the base of the right to file the transitional application and the amendment of the rights to the building whose term has expired in the exercise of the deed of disposal shall be supported by other conditions beside the identity of the applicant as well as the juridical data on the requested land in the form of evidence of expulsion from the bank as a funding institution, in addition to the deed of disposal of rights may be exercised if it meets the authentication requirements of the deed and the validity of an agreement that is the deed of release can be made after the issuance of Land Registration Certificate (SKPT) from the local Land Office.Keywords: Deed of Rights Release, pedestal rights, building use rights

‘The industry must be inconspicuous’: Japan Tobacco’s corruption of science and health policy via the Smoking Research Foundation

ObjectiveTo investigate how and why Japan Tobacco, Inc. (JT) in 1986 established the Smoking Research Foundation (SRF), a research-funding institution, and to explore the extent to which SRF has influenced science and health policy in Japan.MethodsWe analysed documents in the Truth Tobacco Industry Documents archive, along with recent Japanese litigation documents and published documents.ResultsJT’s effort to combat effective tobacco control was strengthened in the mid-1980s, following privatisation of the company. While remaining under the protection of Japan’s Ministry of Finance, the semiprivatised company lost its ‘access to politicos’, opening up a perceived need for collaboration with global cigarette makers. One solution, arrived at through clandestine planning with American companies, was to establish a third-party organisation, SRF, with the hope of capturing scientific and medical authority for the industry. Guarded by powerful people in government and academia, SRF was launched with the covert goal of influencing tobacco policy both inside and outside Japan. Scholars funded by SRF have participated in international conferences, national advisory committees and tobacco litigation, in most instances helping the industry to maintain a favourable climate for the continued sale of cigarettes.ConclusionsContrary to industry claims, SRF was never meant to be independent or neutral. With active support from foreign cigarette manufacturers, SRF represents the expansion into Asia of the denialist campaign that began in the USA in 1953.

PERAN DANA PIHAK KETIGA DALAM KINERJA LEMBAGA PEMBIAYAAN SYARIAH DAN FAKTOR-FAKTOR YANG MEMENGARUHINYA

The development of the performance syariah financing institutions in Indonesia keeps increased positive this can be seen of the total assets and third party funds (DPK) that increase over a period of years 2010-2014. During the period of the year the ratio DPK to the total assets of syariah financing institutions reached 78 percent.The indicated that the role DPK for these very strategic performance and the funding institution banking business. In this paper the tried to explain the role of third party funds in an institution syariah funding as an element the certaintly in the provison of financing and as an element that influences the performance business of syariah financing institutions. The importance of the role of DPK for syariah financing institutions hence need to know the factors that affect the development DPK. Approach analysis this paper is descriptive empirical who testing of theoretically and approach in empirical of studies related.

Investigating alternative access to start-up capital for Tshwane built environment SMMEs

The aim of this study was to investigate alternative access to start-up capital for Built Environment SMMEs from established support and developmental institutions in South Africa. The aim and objectives of the study have been met. The study has shown that Built Environment SMMEs accessing start-up capital from alternative funding institutions and the perceived challenges associated with accessing the finance includes the following: 1) More than half of the sample population did not apply to commercial institution for start-up capital, which may indicate that the SMMEs did not meet the financial requirements of the commercial institution; 2) More than 80% of respondents did not apply to any alternative funding institution to access start-up capital; 3) Approximately 80% of respondents made use of savings and other sources of funding for start-up capital; 4) Most SMMEs are not aware of alternative funding institutions, and that alternative funding institutions are not easily accessible.

An Open Network of Digital Production Centers

In this chapter, the authors present the Network of Digital Production Centers, a modular, scalable scheme for the development of educational and cultural content in schools and nongovernmental organizations (NGOs) in the state of Veracruz, Mexico. The chapter describes its goals, philosophy, its operations, and its growth plans, as well as the results achieved during the first phase of its implementation. The authors frame the project within the overall objectives of its funding institution, the Ibero-American Network for Sustainable Development, an NGO that began this project with the goal of transforming traditional content consumers into developers and producers of educational and cultural digital materials. The learning curve in the field of user multimedia production is steep, but the Network of Digital Production Centers and the Ibero-American Network for Sustainable Development are harvesting the first set of tangible benefits and usable knowledge.

Assessing Precollege Science Education Outreach Initiatives: A Funder's Perspective

We describe an assessment of the collective impact of 35 grants that the Howard Hughes Medical Institute (HHMI) made to biomedical research institutions in 1999 to support precollege science education outreach programs. Data collected from funded institutions were compared with data from a control group of institutions that had advanced to the last stage of review but had not been funded. The survey instrument and the results reveal outcomes and impacts that HHMI considers relevant for these programs. The following attributes are considered: ability to secure additional, non-HHMI funding; institution buy-in as measured by gains in dedicated space and staff; enhancement of the program director's career; number and adoption of educational products developed; number of related publications and awards; percentage of programs for which teachers received course credit; increase in science content knowledge; and increase in student motivation to study science.