Connective tissue diseases and autoimmune thyroid disorders in the first trimester of pregnancy

2016 ◽  
Vol 114 ◽  
pp. 32-37 ◽  
Author(s):  
Fausta Beneventi ◽  
Elena Locatelli ◽  
Roberto Caporali ◽  
Claudia Alpini ◽  
Elisabetta Lovati ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
First Trimester Of Pregnancy

scholarly journals Hydroxychloroquine and the Prevention of Pregnancy Losses

2019 ◽  
pp. 359-366
Author(s):  
Frishman M ◽  
Radin M ◽  
Cecchi I ◽  
Sciascia S ◽  
Schreiber K
Keyword(s):  
Connective Tissue ◽  
Antiphospholipid Antibodies ◽  
Pregnancy Loss ◽  
Chromosomal Abnormalities ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Pregnancy Complication ◽  
Distinct Entity ◽  
Consecutive Pregnancy ◽  
First Trimester Of Pregnancy

Pregnancy loss is a common and devastating pregnancy complication. Recurrent early miscarriage (REM) isdefined as two or more consecutive pregnancy losses during the first trimester of pregnancy. It is a distinct entity and in approximately 50% of these patients, the underlying cause is never established. REM can be idiopathic, i.e. of unknown cause, be related to infections, anatomical or chromosomal abnormalities and can also be related to the presence of autoimmune connective tissue diseases or antiphospholipid antibodies (aPL). Hydroxychloroquine (HCQ) is an antimalarial immunomodulator and is currently being investigated for its role in the prevention of idiopathic REM and REM related to antiphospholipid antibodies (aPL). In this article we review the evidence that exists to date regarding the use of HCQ in the setting of unexplained REM and REM in relation to connective tissue diseases and aPL and antiphospholipid syndrome (APS).

Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy

2012 ◽  
Vol 32 (11) ◽  
pp. 1094-1101 ◽  
Author(s):  
Fausta Beneventi ◽  
Elena Locatelli ◽  
Véronique Ramoni ◽  
Roberto Caporali ◽  
Carlo Maurizio Montecucco ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Uterine Artery ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Obstetric Outcomes ◽  
Doppler Velocimetry ◽  
Uterine Artery Doppler ◽  
First Trimester Of Pregnancy

scholarly journals Thyroid disorders in the first trimester of pregnancy: a cross-sectional study

2020 ◽  
Vol 9 (8) ◽  
pp. 3288
Author(s):  
Rashmi Shankarappa ◽  
Spoorthy Parvathreddy
Keyword(s):  
Normal Limit ◽  
Early Recognition ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Thyroid Disorders ◽  
Sectional Study ◽  
Cross Sectional ◽  
First Trimester Of Pregnancy ◽  
Thyroid Stimulation Hormone ◽  
In Pregnancy

Background: Thyroid disorders in pregnancy are common and are associated with adverse maternal, fetal and neonatal effects. When the prevalence of thyroid disorders is high, then screening for thyroid disorders in early pregnancy can help improve the obstetrical outcome.Methods: Five hundred and fifty women in their first trimester of pregnancy were studied. They were investigated for estimation of free triiodo thyronine (FT3), free thyroxine (FT4) and thyroid stimulation hormone (TSH). The upper normal limit for TSH considered was 4.0 mIU/L.Results: Prevalence of thyroid disorders in the study was 12.6%. Hypothyroidism (12%) was more common than hyperthyroidism (0.6%). Subclinical hypothyroidism was present in 10%.Conclusions: Screening of thyroid disorders is to be considered for all pregnant women. As the prevalence of thyroid disorders is high, early recognition and treatment shall reduce maternal and fetal morbidity.

Thyroid Disorders

2016 ◽  
pp. 203-210
Author(s):  
Marius N. Stan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
First Trimester ◽  
Thyroid Stimulating Hormone ◽  
Primary Hypothyroidism ◽  
Thyroid Disorders ◽  
Hormone Resistance ◽  
Single Test ◽  
Thyrotropin Level ◽  
First Trimester Of Pregnancy

Current assays measure thyrotropin (previously called thyroid-stimulating hormone) concentrations as low as 0.01 mIU/L, allowing differentiation between low-normal values and suppressed values. In patients with normal pituitary, thyrotropin levels are increased in primary hypothyroidism, during recovery from nonthyroid illness, and with thyroid hormone resistance. Thyrotropin levels are low in hyperthyroidism, in nonthyroidal illness, in the first trimester of pregnancy, and with the use of certain drugs (eg, somatostatin, dopamine, and glucocorticoids). Measurement of the thyrotropin level is the best single test of thyroid function in these patients.

Association between previously unknown connective tissue disease and subclinical hypothyroidism diagnosed during first trimester of pregnancy

2015 ◽  
Vol 104 (5) ◽  
pp. 1195-1201 ◽  
Author(s):  
Fausta Beneventi ◽  
Elena Locatelli ◽  
Claudia Alpini ◽  
Elisabetta Lovati ◽  
Véronique Ramoni ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
First Trimester Of Pregnancy

FRACTIONAL DETERMINATIONS OF URINARY 17-KETOSTEROIDS IN HYPEREMESIS GRAVIDARUM

1962 ◽  
Vol 41 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Pentti A. Järvinen ◽  
Sykkö Pesonen ◽  
Pirkko Väänänen
Keyword(s):  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Control Group ◽  
Before And After ◽  
Daily Urine ◽  
First Trimester Of Pregnancy ◽  
The Difference

ABSTRACT The fractional determination of 17-ketosteroids in the daily urine was performed in nine cases of hyperemesis gravidarum and in four control cases, in the first trimester of pregnancy both before and after corticotrophin administration. The excretion of total 17-KS is similar in the two groups. Only in the hyperemesis group does the excretion of total 17-KS increase significantly after corticotrophin administration. The fractional determination reveals no difference between the two groups of patients with regard to the values of the fractions U (unidentified 17-KS), A (androsterone) and Rest (11-oxygenated 17-KS). The excretion of dehydroepiandrosterone is significantly higher in the hyperemesis group than in the control group. The excretion of androstanolone seems to be lower in the hyperemesis group than in the control group, but the difference is not statistically significant. The differences in the correlation between dehydroepiandrosterone and androstanolone in the two groups is significant. The high excretion of dehydroepiandrosterone and low excretion of androstanolone in cases of hyperemesis gravidarum is a sign of adrenal dysfunction.

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