scholarly journals Hydroxychloroquine and the Prevention of Pregnancy Losses

2019 ◽  
pp. 359-366
Author(s):  
Frishman M ◽  
Radin M ◽  
Cecchi I ◽  
Sciascia S ◽  
Schreiber K
Keyword(s):  
Connective Tissue ◽  
Antiphospholipid Antibodies ◽  
Pregnancy Loss ◽  
Chromosomal Abnormalities ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Pregnancy Complication ◽  
Distinct Entity ◽  
Consecutive Pregnancy ◽  
First Trimester Of Pregnancy

Pregnancy loss is a common and devastating pregnancy complication. Recurrent early miscarriage (REM) isdefined as two or more consecutive pregnancy losses during the first trimester of pregnancy. It is a distinct entity and in approximately 50% of these patients, the underlying cause is never established. REM can be idiopathic, i.e. of unknown cause, be related to infections, anatomical or chromosomal abnormalities and can also be related to the presence of autoimmune connective tissue diseases or antiphospholipid antibodies (aPL). Hydroxychloroquine (HCQ) is an antimalarial immunomodulator and is currently being investigated for its role in the prevention of idiopathic REM and REM related to antiphospholipid antibodies (aPL). In this article we review the evidence that exists to date regarding the use of HCQ in the setting of unexplained REM and REM in relation to connective tissue diseases and aPL and antiphospholipid syndrome (APS).

Connective tissue diseases and autoimmune thyroid disorders in the first trimester of pregnancy

2016 ◽  
Vol 114 ◽  
pp. 32-37 ◽  
Author(s):  
Fausta Beneventi ◽  
Elena Locatelli ◽  
Roberto Caporali ◽  
Claudia Alpini ◽  
Elisabetta Lovati ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
First Trimester Of Pregnancy

Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy

2012 ◽  
Vol 32 (11) ◽  
pp. 1094-1101 ◽  
Author(s):  
Fausta Beneventi ◽  
Elena Locatelli ◽  
Véronique Ramoni ◽  
Roberto Caporali ◽  
Carlo Maurizio Montecucco ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Uterine Artery ◽  
Connective Tissue Diseases ◽  
First Trimester ◽  
Obstetric Outcomes ◽  
Doppler Velocimetry ◽  
Uterine Artery Doppler ◽  
First Trimester Of Pregnancy

scholarly journals Distribution of diandric and digynic triploidy depending on gestational age

2021 ◽  
Author(s):  
Diana Massalska ◽  
Katarzyna Ozdarska ◽  
Tomasz Roszkowski ◽  
Julia Bijok ◽  
Anna Kucińska-Chahwan ◽  
...  
Keyword(s):  
Gestational Age ◽  
Pregnancy Loss ◽  
First Trimester ◽  
Parental Origin ◽  
Second Trimester ◽  
Chain Reaction ◽  
Spontaneous Pregnancy ◽  
First Trimester Of Pregnancy ◽  
Polymerase Chain ◽  
Fluorescent Polymerase Chain Reaction

Abstract Purpose To establish the distribution of diandric and digynic triploidy depending on gestational age. Methods 107 triploid samples tested prospectively in a single genetic department during a four-year period were analyzed for parental origin of triploidy by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) (n=95) with the use of matching parental samples or by MS-MLPA (n=12), when parental samples were unavailable. Tested pregnancies were divided into three subgroups with regard to the gestational age at spontaneous pregnancy loss: <11 gestational weeks, 11–14 gestational weeks, and >14 gestational weeks. Results Diandric triploidy constituted overall 44.9% (46.5% in samples miscarried <11 gestational weeks, 64.3% in samples miscarried between 11 and 14 gestational weeks, and 27.8% in pregnancies which survived >14 gestational weeks). Conclusions The distribution of diandric and digynic triploidy depends on gestational age. The majority of diandric triploid pregnancies is lost in the first trimester of pregnancy. In the second trimester, diandric cases are at least twice less frequent than digynic ones.

scholarly journals Efficiency of early monitoring gestational process in women with risk of pregnancy loss

2021 ◽  
Vol 51 (4) ◽  
pp. 8-12
Author(s):  
V. E. Radzinskiy ◽  
E. M. Demidova ◽  
M. Y Bazovaia ◽  
I. M. Ordiyants
Keyword(s):  
Enzyme Activity ◽  
Blood Plasma ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
First Trimester ◽  
First Trimester Of Pregnancy ◽  
Definition Of

This article is devoted to optimization of dispensary observation at the eshlia terms of gestation of women suffer from sporadic miscaniages in anamnesis as well as tlie definition of prognostic meaning of the ultmsonic doppleromet-ry criterias, the enzyme activity of lisosomal of blood plasma and tlie cytochemical mte (DCR) for tlie segmentnuclear leucocytes at the pregnant women witli pathological obstetl'ic anamnesis. 13 7p1-egnant women were tested, 98 o f them at the earlier terms o f gest-ation from 7 to 14 weelis of t-heir pregnancy. The received data show that metabolic conection and normalization of microbiocenosis of vagina and cavix channel in tlie first trimester of pregnancy is pathogen validity, they promot-e tlie nmwaf pregnancy of the next terms of gestation and decrease tlie frequency of repeat-ed misriages

scholarly journals Increased Pregnancy Loss Rate in Thyroid Antibody Negative Women with TSH Levels between 2.5 and 5.0 in the First Trimester of Pregnancy

2010 ◽  
Vol 95 (9) ◽  
pp. E44-E48 ◽  
Author(s):  
Roberto Negro ◽  
Alan Schwartz ◽  
Riccardo Gismondi ◽  
Andrea Tinelli ◽  
Tiziana Mangieri ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Loss Rate ◽  
First Trimester ◽  
Thyroid Antibody ◽  
First Trimester Of Pregnancy ◽  
Tsh Levels

Identifying additional risk factors for arterial and venous thrombosis among pediatric antiphospholipid antibodies carriers

Lupus ◽  
2021 ◽  
pp. 096120332110022
Author(s):  
Elizabeth Sloan ◽  
Tracey Wright ◽  
Yu Zuo
Keyword(s):  
Risk Factors ◽  
Connective Tissue ◽  
Venous Thrombosis ◽  
Antiphospholipid Antibodies ◽  
Arterial Thrombosis ◽  
Pediatric Patients ◽  
Univariate Analysis ◽  
Connective Tissue Diseases ◽  
Additional Risk ◽  
Potential Predictor

Background Antiphospholipid antibodies (aPL) have been extensively reported in children, but investigations into thrombotic risks associated with aPL positivity in pediatric patients is scarce. Positive aPL are not uncommon in pediatric connective tissue diseases (CTD), but identification and management of these patients is challenging due to lack of validated criteria and a paucity of data. In this study, we identify potential additional risk factors for thrombosis in a unique cohort of pediatric aPL positive carriers. Methods Retrospective chart review was performed on 491 pediatric patients with CTD seen in our institution from 2001 to 2019. Patients without persistently moderate to high titer aPL at least 12 weeks apart were excluded. Univariate analysis was performed to evaluate correlation between different risk factors and thrombotic events. Results Seventy-one aPL positive children with underlying CTD are included in this cohort. The majority (87%) are female and of Hispanic ethnicity (56%). Mean age of the cohort at the diagnosis of connective tissue disease is 12.7 (SD 2.6) years, and mean age of first positive aPL is 13.3 (SD 2.5) years. Average length of follow-up is 4.3 (SD 2.5) years. Four (5.6%) patients experienced arterial thrombosis, and 11 (15.5%) had venous thrombosis. Fifty-seven (80.3%) patients did not have any thromboembolic events. Among traditional risk factors and signs of endothelial injury, only Raynaud’s phenomena demonstrated significant association with arterial thrombosis (OR = 8.4, 95%CI 1.13–111, P = 0.039), and hypertension or anti-hypertensive use demonstrated significant association with venous thrombosis (OR = 8.387, 95%CI 1.2 – 94, P = 0.02). Conclusion Data from our cohort suggest that Raynaud’s phenomenon is a potential predictor of arterial thrombosis while the presence of hypertension or anti-hypertensive medication use is a potential predictor of venous thrombosis in aPL positive pediatric carriers. Further studies investigating pediatric aPL profiles and risk factors for development of thrombosis are needed to help guide clinicians in caring for these challenging patients.

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