Identification of high responders for interleukin-6 and creatine kinase following acute eccentric resistance exercise in elderly obese women

The present investigations were aimed to identify the possible association between genetic polymorphism in interleukin-6 (IL-6) G-174C gene, which confers susceptibility to metabolic syndrome, and serum level of resistin in North Indian women. The study population comprised 370 unrelated Indian women (192 having abdominal obesity and 178 controls). Polymorphism in genotype (CC+GC) of IL-6 G-174C gene was determined using a combination of polymerase chain reaction (PCR) and sequence-specific primer with restriction fragment length polymorphism (RFLP) technology. Insulin resistance (IR) and serum resistin level were also analyzed along with metabolic risk factors. Of 192 abdominal obese women, 147 (76.56%) were found to have mutant CC+GC ( p = 0.001) genotype and allele frequency ( p = 0.001), which was significantly higher 45 (23.44%) than non-obese and their respective wild type. The mutant genotype (CC+GC) of IL-6 gene was found to be associated significantly with high triglyceride ( p = 0.025) and resistin level ( p < 0.001), when compared with respective wild genotype (GG) in obese women. Non-obese women with no signs of metabolic risk factors were found to have significantly low level of serum resistin and IR in comparison to obese women having genetic polymorphism for IL-6 G-174C gene. Study suggests that IL-6 G-174C gene is one among the susceptibility loci for metabolic syndrome in North Indian women. Genotype for this polymorphism may prove informative for prediction of genetic risk for metabolic syndrome. Further, high level of serum resistin molecules may be targeted to correlate with metabolic syndrome risk factors and could be used as early prediction marker.

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Creatine Kinase and Lactate Dehydrogenase Responses After Different Resistance and Aerobic Exercise Protocols

Journal of Human Kinetics ◽

10.1515/hukin-2017-0071 ◽

2017 ◽

Vol 58 (1) ◽

pp. 65-72 ◽

Cited By ~ 17

Author(s):

Gustavo A. Callegari ◽

Jefferson S. Novaes ◽

Gabriel R. Neto ◽

Ingrid Dias ◽

Nuno D. Garrido ◽

...

Keyword(s):

Creatine Kinase ◽

Lactate Dehydrogenase ◽

Resistance Exercise ◽

Aerobic Exercise ◽

Aerobic Training ◽

Body Height ◽

Blood Samples ◽

Set Protocol ◽

Experimental Protocols ◽

Elevate Plasma

AbstractThe aim of this study was to investigate the responses of creatine kinase (CK) and lactate dehydrogenase (LDH) after performing different resistance and aerobic exercise protocols. Twelve recreationally trained men (age, 23.2 ± 5.6 years; body mass, 84.3 ± 9.3 kg; body height, 178.9 ± 4.5 cm; and BMI, 26.3 ± 2.3 kg·m2) volunteered to participate in this study. All subjects were randomly assigned to four experimental protocols (crossover): (a) aerobic training at 60% of VO2max, (b) aerobic training at 80% of VO2max, (c) a resistance exercise (RE) session with a bi-set protocol, and (d) an RE session with a multiple sets protocol. Blood samples were collected before, immediately after and 24 hours following the experimental protocols. After 24 hours, there was a significant increase in CK for the 80% of VO2max protocol vs. the bi-set RE session (p = 0.016). Immediately after the protocols, we observed a significant increase in LDH among certain groups compared to others, as follows: multiple sets RE session vs. 60% of VO2max, bi-set RE session vs. 60% of VO2max, multiple sets RE session vs. 80% of VO2max, and bi-set RE session vs. 80% of VO2max (p = 0.008, p = 0.013; p = 0.002, p = 0.004, respectively). In conclusion, aerobic exercise performed at 80% of VO2max appears to elevate plasma CK levels more than bi-set RE sessions. However, the bi-set and multiple sets RE sessions appeared to trigger greater levels of blood LDH compared to aerobic protocols performed at 60% and 80% of VO2max.

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Effect of Resistance Exercise Using Water Bottles and Pilates Exercise on Atherosclerosis Indices and Inflammation Related Markers in Elderly Obese Women

Journal of Sport and Leisure Studies ◽

10.51979/kssls.2014.11.58.913 ◽

2014 ◽

Vol 58 ◽

pp. 913-921

Author(s):

Nam-Jung Kim

Keyword(s):

Resistance Exercise ◽

Obese Women

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Effect of consecutive aerobic and resistance exercise on cortisol, immunoglobulin A, and creatine kinase responses in male students

Biomedical Human Kinetics ◽

10.2478/v10101-011-0025-2 ◽

2011 ◽

Vol 3 ◽

Author(s):

Hamid Arazi ◽

Mohammad Azizi

Keyword(s):

Creatine Kinase ◽

Resistance Exercise ◽

Immunoglobulin A ◽

Male Students

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Short-term l -arginine supplementation attenuates elevation of interleukin 6 level after resistance exercise in overweight men

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2017.09.001 ◽

2017 ◽

Vol 22 ◽

pp. 43-47

Author(s):

Marcos Antonio do Nascimento ◽

Fábio dos Santos Lira ◽

Giovana Rita Punaro ◽

Marco Túlio de Mello ◽

Sérgio Tufik ◽

...

Keyword(s):

Resistance Exercise ◽

Interleukin 6 ◽

Short Term ◽

Arginine Supplementation

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Creatine supplementation: effects on blood creatine kinase activity responses to resistance exercise and creatine kinase activity measurement

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s1984-82502009000400020 ◽

2009 ◽

Vol 45 (4) ◽

pp. 751-757 ◽

Cited By ~ 5

Author(s):

Marco Machado ◽

Rafael Pereira ◽

Felipe Sampaio-Jorge ◽

Franz Knifis ◽

Anthony Hackney

Keyword(s):

Creatine Kinase ◽

Resistance Exercise ◽

Kinase Activity ◽

Training Session ◽

Creatine Supplementation ◽

Creatine Kinase Activity ◽

Exercise Session ◽

Activity Measurement ◽

Double Blind Study ◽

Leg Extension

The purpose of this study was to determine the effects of creatine supplementation and exercise on the integrity of muscle fiber, as well as the effect of the supplementation on the creatine kinase (CK) assay measurement. Forty-nine sedentary individuals participated in a double-blind study and were divided into two groups: C (n=26) received 4x5-day packages of 0.6 g.kg-1 of body weight contained 50% of creatine + 50% of dextrose, and P (n=23) received packages containing only dextrose. On the first day the groups performed a 1RM test for bench press, seated row, leg extension, leg curl and leg press. On D7 they received the supplements. On the fourteenth day, they performed a training session of five exercises, each in three sets of ten repetitions at 75% of 1RM. Blood was collected before (D14) and after the exercise session (D15). Differing levels of blood creatine were tested to determine the influence on the assay measurements of CK. ANOVA and Tukey's post-hoc tests were used to compare groups and different times of study protocol (P<0.05). No changes were observed in CK activity of the groups from D0, D7 and D14. On D15 CK activity increases 140% (women) and 200% (men). There was no difference in CK activity between groups. Blood creatine levels up to 5mM produced no significant effect on CK assay results. CK activity increased after resistance exercise, while creatine supplementation produced no difference in the muscle cellular integrity nor compromised assay methodology.

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