Shark centra microanatomy and mineral density variation studied with laboratory microComputed Tomography

2022 ◽  
pp. 107831
Author(s):  
Paul E. Morse ◽  
Michala K. Stock ◽  
Kelsey C. James ◽  
Lisa J. Natanson ◽  
Stuart R. Stock
Keyword(s):  
Microcomputed Tomography ◽  
Density Variation ◽  
Mineral Density

scholarly journals Is Population Bone Mineral Density Variation Linked to the Marker D11S987 On Chromosome 11q12–13?

2001 ◽  
Vol 86 (8) ◽  
pp. 3735-3741 ◽  
Author(s):  
Hong-Wen Deng ◽  
Fu-Hua Xu ◽  
Theresa Conway ◽  
Xu-Tao Deng ◽  
Jin-Long Li ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Density Variation ◽  
Mineral Density

scholarly journals Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci

Bone ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 443-448 ◽  
Author(s):  
Munro Peacock ◽  
Daniel L. Koller ◽  
Dongbing Lai ◽  
Siu Hui ◽  
Tatiana Foroud ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Quantitative Trait Loci ◽  
Bone Mineral ◽  
Quantitative Trait ◽  
Density Variation ◽  
Mineral Density ◽  
Trait Loci

scholarly journals A follow-up association study of two genetic variants for bone mineral density variation in Caucasians

2011 ◽  
Vol 23 (7) ◽  
pp. 1867-1875 ◽  
Author(s):  
L.-S. Zhang ◽  
H.-G. Hu ◽  
Y.-J. Liu ◽  
J. Li ◽  
P. Yu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Association Study ◽  
Bone Mineral ◽  
Genetic Variants ◽  
Density Variation ◽  
Mineral Density

scholarly journals An approach to compare the quality of cancellous bone from the femoral necks of healthy and osteoporotic patients through compression testing and microcomputed tomography imaging

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Anthony Ciarallo ◽  
Jake Barralet ◽  
Michael Tanzer ◽  
Richard Kremer
Keyword(s):  
Bone Quality ◽  
Cancellous Bone ◽  
Hip Replacement ◽  
Bone Biopsy ◽  
Microcomputed Tomography ◽  
The United States ◽  
Compression Testing ◽  
Mineral Density ◽  
Effective Prevention

It is estimated that osteoporosis is responsible for about 300 000 hip fractures per year in the United States. Effective prevention of these fractures has been demonstrated using bisphosphonates. However, their mechanism of action has not been elucidated. Furthermore, the precise effect of bisphosphonates on the femoral neck and surrounding areas has never been studied. We are interested in establishing a protocol to analyze the bone quality of proximal femurs from patients treated with bisphosphonates. Following hip replacement surgery, the aim is to determine whether imaging and compression testing of cancellous bone from the discarded femoral necks can accurately assess the bone’s microarchitectural and biomechanical properties, respectively. To validate the technique, it was first tested on an untreated population. A bone biopsy trephine was used to extract cylindrical cores of trabecular bone from the centre of femoral necks. Densitometry, microcomputed tomography, and compression testing were used to assess the quality of bone in these samples. The compressive strength was found to be directly proportional to the modulus (i.e. stiffness) of the samples, thus reproducing previous findings. The relative porosity and, to a lesser extent, the bone mineral density were capable of predicting the quality of cancellous bone. In conclusion, a protocol to analyze the bone quality in human femoral necks using μCT and biomechanical compression testing was successfully established. It will be applied in a clinical setting to analyze bones from bisphosphonate-treated patients following total hip replacement.

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