The possible role of the transcription factor nuclear factor-κB on evolution of rotator cuff tear and on mechanisms of cuff tendon healing

Abstract The pivotal role of tumor-associated macrophages (TAMs) in tumor progression is now well established. TAMs have been shown to influence multiple steps in tumor development including the growth, survival, invasion, and metastasis of tumor cells as well as angiogenesis and lymphangiogenesis in tumors. The molecular circuits that polarize TAMs toward such a protumoral phenotype are now the focus of intense investigation. The transcription factor, nuclear factor–κB (NF-κB), is a master regulator of many cellular processes and been shown to regulate various pathways that impact on the function of TAMs. Much evidence for this has come from the use of elegant transgenic murine tumor models in which modification of single components of the NF-κB signaling pathway has been shown to regulate the pro-tumor repertoire of TAMs. Here, we outline this evidence and attempt to reconcile the various views that have emerged recently over the exact role of NF-κB in this phenomenon.

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Spontaneous, homeostatic, and inflammation-induced sleep in NF-κB p50 knockout mice

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00262.2006 ◽

2006 ◽

Vol 291 (5) ◽

pp. R1516-R1526 ◽

Cited By ~ 18

Author(s):

K. A. Jhaveri ◽

V. Ramkumar ◽

R. A. Trammell ◽

L. A. Toth

Keyword(s):

Transcription Factor ◽

Influenza Virus ◽

Slow Wave Sleep ◽

Nuclear Factor Κb ◽

Nuclear Factor ◽

Immune Challenge ◽

Rapid Eye Movement Sleep ◽

Sleep Regulation ◽

Transcription Factor Nuclear Factor

The dimeric transcription factor nuclear factor-κB (NF-κB) regulates several endogenous sleep-modulatory substances and thereby serves as a pivotal mediator of sleep-wake homeostasis. To further define the role of NF-κB in sleep regulation, we monitored sleep and temperature in mice that lack the p50 subunit of NF-κB [p50 knockout (KO) mice]. Compared with the control B6129PF2/J strain, p50 KO mice spend more time in slow-wave sleep (SWS) and rapid eye movement sleep (REMS) under normal conditions and show enhanced homeostatic recovery of sleep after sleep loss. p50 KO mice also show increased SWS and reduced REMS and temperature after the administration of lipopolysaccharide, yet they are behaviorally less responsive to challenge with influenza virus. These data support a role for NF-κB, and, in particular, for the p50 subunit, in the regulation of sleep in healthy mice and in mice experiencing immune challenge.

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Sodium Salicylate Inhibits Cyclo-Oxygenase-2 Activity Independently of Transcription Factor (Nuclear Factor κB) Activation: Role of Arachidonic Acid

Molecular Pharmacology ◽

10.1124/mol.51.6.907 ◽

1997 ◽

Vol 51 (6) ◽

pp. 907-912 ◽

Cited By ~ 81

Author(s):

Jane A. Mitchell ◽

Michael Saunders ◽

Peter J. Barnes ◽

Robert Newton ◽

Maria G. Belvisi

Keyword(s):

Transcription Factor ◽

Arachidonic Acid ◽

Sodium Salicylate ◽

Nuclear Factor Κb ◽

Nuclear Factor ◽

Transcription Factor Nuclear Factor

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Immunolocalization and Activation of Transcription Factor Nuclear Factor κB in Dysimmune Neuropathies and Familial Amyloidotic Polyneuropathy

Archives of Neurology ◽

10.1001/archneur.61.7.1097 ◽

2004 ◽

Vol 61 (7) ◽

Cited By ~ 16

Author(s):

Anna Mazzeo ◽

Mohammed Aguennouz ◽

Corrado Messina ◽

Giuseppe Vita

Keyword(s):

Transcription Factor ◽

Nuclear Factor Κb ◽

Familial Amyloidotic Polyneuropathy ◽

Nuclear Factor ◽

Activation Of Transcription ◽

Dysimmune Neuropathies ◽

Transcription Factor Nuclear Factor

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The use of siRNA as a pharmacological tool to assess a role for the transcription factor NF-IL6 in the brain under in vitro and in vivo conditions during LPS-induced inflammatory stimulation

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2017-0017 ◽

2017 ◽

Vol 28 (6) ◽

Cited By ~ 2

Author(s):

Jelena Damm ◽

Joachim Roth ◽

Rüdiger Gerstberger ◽

Christoph Rummel

Keyword(s):

Transcription Factor ◽

Brain Cells ◽

Nuclear Factor ◽

Si Rna ◽

The Brain ◽

Deficient Mice ◽

Transcription Factor Nuclear Factor

AbstractBackground:Studies with NF-IL6-deficient mice indicate that this transcription factor plays a dual role during systemic inflammation with pro- and anti-inflammatory capacities. Here, we aimed to characterize the role of NF-IL6 specifically within the brain.Methods:In this study, we tested the capacity of short interfering (si) RNA to silence the inflammatory transcription factor nuclear factor-interleukin 6 (NF-IL6) in brain cells underResults:In cells of a mixed neuronal and glial primary culture from the ratConclusions:This approach was, thus, not suitable to characterize the role NF-IL6 in the brain

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The association between Interleukin-6 rs1800795/rs1800797 polymorphisms and risk of rotator cuff tear in a Chinese population

Bioscience Reports ◽

10.1042/bsr20200193 ◽

2020 ◽

Vol 40 (4) ◽

Cited By ~ 1

Author(s):

Jin Li ◽

Lifeng Jiang ◽

Xindie Zhou ◽

Lidong Wu ◽

Dong Li ◽

...

Keyword(s):

Rotator Cuff ◽

Rotator Cuff Tear ◽

Constant Score ◽

Enzyme Linked Immunosorbent Assay ◽

Mutant Genotype ◽

Cuff Tear ◽

Increased Risk ◽

Polymerase Chain ◽

Tear Size

Abstract Expression of proinflammatory cytokines, such as interleukin (IL)-6 (IL-6) and metalloproteases, are elevated in patients with rotator cuff tear (RCT). In order to investigate the role of IL-6 gene polymorphisms on RCT risk, we genotyped two SNPs on IL-6 gene (rs1800795 and rs1800797) in 138 RCT patients and 137 healthy controls using polymerase chain reaction (PCR) and Sanger sequencing. The IL-6 expression in shoulder joint synovial fluid was determined by using enzyme-linked immunosorbent assay (ELISA) method. The constant score and visual analog scale (VAS) were used to evaluate the clinical outcome of two s (surgicsal vs. conservative) for RCT patients. For rs1800795, individuals with the GG genotype or G allele had significantly higher risk of RCT. Elevated risk of tear size was associated with the GG genotype of the rs1800795 polymorphism. The IL-6 rs1800797 polymorphism was also associated with an increased risk of RCT, especially among female, drinkers, and individuals with B(MI) < 25 kg/m2. The elevated levels of IL-6 gene were observed among the mutant genotype of rs1800795/rs1800797 polymorphism. Surgical group is significantly better than conservative treatment from the perspective of constant score and VAS. Furthermore, CG genotype of rs1800795 polymorphism increased the constant score at 6 months in comparison with CC genotype. In conclusion, our study supports a role of IL-6 rs1800795/rs1800797 polymorphisms on increased RCT risk. The RCT patients with CG genotype of rs1800795 polymorphism have more obvious surgical treatment effects by influencing the IL-6 expression.

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