The use of siRNA as a pharmacological tool to assess a role for the transcription factor NF-IL6 in the brain under in vitro and in vivo conditions during LPS-induced inflammatory stimulation
2017 ◽
Vol 28
(6)
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Keyword(s):
Si Rna
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AbstractBackground:Studies with NF-IL6-deficient mice indicate that this transcription factor plays a dual role during systemic inflammation with pro- and anti-inflammatory capacities. Here, we aimed to characterize the role of NF-IL6 specifically within the brain.Methods:In this study, we tested the capacity of short interfering (si) RNA to silence the inflammatory transcription factor nuclear factor-interleukin 6 (NF-IL6) in brain cells underResults:In cells of a mixed neuronal and glial primary culture from the ratConclusions:This approach was, thus, not suitable to characterize the role NF-IL6 in the brain
2009 ◽
Vol 207
(1)
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pp. 117-128
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Keyword(s):
Keyword(s):
2002 ◽
Vol 159
(5)
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pp. 867-880
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The Role of the Transcription Factor Nuclear Factor Kappa B in the Regulation of Cardiac Hypertrophy
2010 ◽
Vol 17
(4)
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pp. 209-217
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2005 ◽
Vol 25
(5)
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pp. 2000-2013
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Keyword(s):
1995 ◽
Vol 182
(1)
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pp. 243-248
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Keyword(s):
2014 ◽
Vol 25
(14)
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pp. 2199-2215
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Keyword(s):