First clinical experience with a new injectable recombinant human collagen scaffold combined with autologous platelet-rich plasma for the treatment of lateral epicondylar tendinopathy (tennis elbow)

Digital flexor tendon injuries are the most common cause of early retirement and economic loss in the equine industry due to the poor healing tendency of the tendons. This study was conducted to improve the quality of tendon healing by using Autologous Platelet Rich Plasma incorporated collagen scaffold. Using ultrasound guidance, autologous Platelet Rich Plasma with and without collagen scaffold was engrafted intra-lesionally into 12 affected digital flexor tendons of 11 horses and healing was assessed periodically. Lameness score decreased in all the horses and the therapeutic outcome of intra-lesional engraftment of Autologous Platelet Rich Plasma with collagen scaffold was found to be superior in terms of clinical outcome, ultrasonographic and biochemical assessment. Ultrasonography served as an effective tool for diagnosis and for evaluation of healing tendon injuries.

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Functional outcome of autologous platelet rich plasma injection in plantar fasciitis and tennis elbow

IP International Journal of Orthopaedic Rheumatology ◽

10.18231/j.ijor.2021.017 ◽

2022 ◽

Vol 7 (2) ◽

pp. 76-81

Author(s):

Rameshwar Sharan Gupta ◽

Manish Khanna

Keyword(s):

Repeated Measures ◽

Plantar Fasciitis ◽

Tennis Elbow ◽

Platelet Rich Plasma ◽

Biological Response ◽

Osteoblastic Differentiation ◽

Plasma Injection ◽

Significant Difference ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

Recent developments in cellular and molecular biology have emerged as a potent tool in the management of orthopaedic illnesses and injuries. Upon binding to the target cell receptor, the growth factor from platelets triggers the activation of an intracellular signal transduction system, which results in a biological response that is essential for chemotaxis, cell proliferation, and osteoblastic differentiation. The aim of this study is to determine the efficacy and safety of autologous platelet-rich plasma injection in tennis elbow and plantar fasciitis. We conducted a prospective study with patients who were suffering from plantar fasciitis (n=37) or tennis elbow (n=23) and were given with autologous platelet-rich plasma injection. A short term follow up of all these cases were done at regular intervals for 1, 4, 8, and 12 weeks. The clinical outcomes were analyzed with severity of pain and movements of the pathological part. The functional outcomes were analyzed with VAS and AOFAS scoring for plantar fasciitis and VAS and Mayo’s elbow scoring for tennis elbow. All these patients were statistically analyzed by repeated measures ANOVA test. Our investigation found a statistically significant difference between pre-procedural and post-procedural scores in both the subjective (VAS) and functional (AOFAS and Mayo elbow score) grading systems used in this study. Patients who received an autologous platelet-rich plasma injection experienced a statistically significant (p <0.05) improvement in their ability to combat both of the musculoskeletal illnesses studied. Autologous platelet-rich plasma acts as a promising efficacious biological therapeutic agent for use in musculoskeletal disorders such as plantar fasciitis and tennis elbow without major complications upon its usage.

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Effect of autologous adipose-derived mesenchymal stem cell therapy in combination with autologous platelet-rich plasma in the treatment of elbow tendinopathy

BMJ Case Reports ◽

10.1136/bcr-2020-234592 ◽

2020 ◽

Vol 13 (6) ◽

pp. e234592

Author(s):

Julien Freitag ◽

Kiran Shah ◽

James Wickham ◽

Abi Tenen

Keyword(s):

Rating Scale ◽

Tennis Elbow ◽

Platelet Rich Plasma ◽

Cell Lineage ◽

Clinical History ◽

Mesodermal Cell ◽

Mesenchymal Stem Cell Therapy ◽

Patient Reported ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

Tendinopathy is a common condition of both the athletic and general population and can be associated with significant pain and disability. The ability of mesenchymal stem cells (MSCs) to differentiate along a mesodermal cell lineage, including tenocytes, and secrete various bioactive regenerative and anti-inflammatory molecules has seen them considered as a future reparative therapy for tendinopathy. Preclinical trials with MSCs have shown promising positive functional and structural outcomes in several connective tissue related conditions. A 52-year-old male professional masters golfer presents with a clinical history of common extensor origin tendinopathy of the elbow. Subsequent formal ultrasound showed evidence of a large intrasubstance tear. The patient underwent intratendinous autologous adipose-derived MSC therapy in combination with autologous platelet-rich plasma. Following treatment, the patient reported progressive improvement as measured by the validated Numeric Pain Rating Scale and Patient-Rated Tennis Elbow Evaluation score. Repeat imaging showed successful regeneration of tendon-like tissue.

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Autologous platelet-rich plasma injection in tennis elbow and plantar fasciitis

Current Orthopaedic Practice ◽

10.1097/bco.0000000000000393 ◽

2016 ◽

Vol 27 (4) ◽

pp. 405-408 ◽

Cited By ~ 1

Author(s):

S.K.Venkatesh Gupta ◽

Divya Bandari

Keyword(s):

Plantar Fasciitis ◽

Tennis Elbow ◽

Platelet Rich Plasma ◽

Plasma Injection ◽

Autologous Platelet Rich Plasma ◽

Autologous Platelet

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EFFECTIVENESS OF AUTOLOGOUS PLATELET RICH PLASMA (PRP) IN TREATMENT OF CHRONIC AND RECURRENT TENDINOPATHIES

10.36106/gjra/6508304 ◽

2020 ◽

pp. 42-46

Author(s):

Rajeev Kumar Kansay ◽

Sandeep Kumar Jindal ◽

Ashwani Soni ◽

Sonam Kansay

Keyword(s):

Tennis Elbow ◽

Platelet Rich Plasma ◽

Daily Routine ◽

Base Line ◽

Achilles Tendinitis ◽

Vas Score ◽

Study Population ◽

Autologous Platelet Rich Plasma ◽

Time Of Presentation ◽

Autologous Platelet

Background & Objective: Chronic and Recurrent Tendinopathies causes variable pain and functional impairment in daily routine activities. They are slow to heal and their treatment poses a great challenge for the treating Clinician. Therefore, this study was initiated to explore the effectiveness of PRP in recurrent tendinopathies. Material and Methods: The study population comprised of patients with chronic or recurrent: Achilles tendinitis (AT), Tennis elbow (TE) or Plantar Fasciitis (PF) and were given autologous platelet rich plasma (PRP) injection locally at point of maximal tenderness. The Visual Analog Scale (VAS) was filled by the concerned clinician at base line (Day1), at 6 weeks and 6 months after the procedure. Results: The study included 48 patients with mean age 49.5 ± 10.98 years. There were 18 male and 30 females. Mean VAS score of all 48 patients at the time of presentation was 8.8 ± 0.73. Mean VAS score when calculated separately for AT, TE and PF were 8.3 ± 0.48, 9.4 ± 0.5 and 9.5 ± 0.54 respectively. Mean VAS score decreased at 6 weeks and at 6 months to 1.8 ± 2.2 and 0.72 ± 1.88 respectively for all 48 patients. This decrease in VAS score at 6 weeks and at 6 months was significant when compared for all 48 patients. When compared separately, decrease in VAS at 6 weeks and 6 months was significant for AT and TE group. Conclusions: Local injection of autologous PRP proved to be a promising form of therapy for TE and AT. It is safe and extremely effective in relieving pain and improving function in chronic and recurrent tendinopathies.

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