scholarly journals EFFECTIVENESS OF AUTOLOGOUS PLATELET RICH PLASMA (PRP) IN TREATMENT OF CHRONIC AND RECURRENT TENDINOPATHIES

2020 ◽  
pp. 42-46
Author(s):  
Rajeev Kumar Kansay ◽  
Sandeep Kumar Jindal ◽  
Ashwani Soni ◽  
Sonam Kansay
Keyword(s):  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Daily Routine ◽  
Base Line ◽  
Achilles Tendinitis ◽  
Vas Score ◽  
Study Population ◽  
Autologous Platelet Rich Plasma ◽  
Time Of Presentation ◽  
Autologous Platelet

Background & Objective: Chronic and Recurrent Tendinopathies causes variable pain and functional impairment in daily routine activities. They are slow to heal and their treatment poses a great challenge for the treating Clinician. Therefore, this study was initiated to explore the effectiveness of PRP in recurrent tendinopathies. Material and Methods: The study population comprised of patients with chronic or recurrent: Achilles tendinitis (AT), Tennis elbow (TE) or Plantar Fasciitis (PF) and were given autologous platelet rich plasma (PRP) injection locally at point of maximal tenderness. The Visual Analog Scale (VAS) was filled by the concerned clinician at base line (Day1), at 6 weeks and 6 months after the procedure. Results: The study included 48 patients with mean age 49.5 ± 10.98 years. There were 18 male and 30 females. Mean VAS score of all 48 patients at the time of presentation was 8.8 ± 0.73. Mean VAS score when calculated separately for AT, TE and PF were 8.3 ± 0.48, 9.4 ± 0.5 and 9.5 ± 0.54 respectively. Mean VAS score decreased at 6 weeks and at 6 months to 1.8 ± 2.2 and 0.72 ± 1.88 respectively for all 48 patients. This decrease in VAS score at 6 weeks and at 6 months was significant when compared for all 48 patients. When compared separately, decrease in VAS at 6 weeks and 6 months was significant for AT and TE group. Conclusions: Local injection of autologous PRP proved to be a promising form of therapy for TE and AT. It is safe and extremely effective in relieving pain and improving function in chronic and recurrent tendinopathies.

Functional outcome of autologous platelet rich plasma injection in plantar fasciitis and tennis elbow

2022 ◽  
Vol 7 (2) ◽  
pp. 76-81
Author(s):  
Rameshwar Sharan Gupta ◽  
Manish Khanna
Keyword(s):  
Repeated Measures ◽  
Plantar Fasciitis ◽  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Biological Response ◽  
Osteoblastic Differentiation ◽  
Plasma Injection ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Recent developments in cellular and molecular biology have emerged as a potent tool in the management of orthopaedic illnesses and injuries. Upon binding to the target cell receptor, the growth factor from platelets triggers the activation of an intracellular signal transduction system, which results in a biological response that is essential for chemotaxis, cell proliferation, and osteoblastic differentiation. The aim of this study is to determine the efficacy and safety of autologous platelet-rich plasma injection in tennis elbow and plantar fasciitis. We conducted a prospective study with patients who were suffering from plantar fasciitis (n=37) or tennis elbow (n=23) and were given with autologous platelet-rich plasma injection. A short term follow up of all these cases were done at regular intervals for 1, 4, 8, and 12 weeks. The clinical outcomes were analyzed with severity of pain and movements of the pathological part. The functional outcomes were analyzed with VAS and AOFAS scoring for plantar fasciitis and VAS and Mayo’s elbow scoring for tennis elbow. All these patients were statistically analyzed by repeated measures ANOVA test. Our investigation found a statistically significant difference between pre-procedural and post-procedural scores in both the subjective (VAS) and functional (AOFAS and Mayo elbow score) grading systems used in this study. Patients who received an autologous platelet-rich plasma injection experienced a statistically significant (p <0.05) improvement in their ability to combat both of the musculoskeletal illnesses studied. Autologous platelet-rich plasma acts as a promising efficacious biological therapeutic agent for use in musculoskeletal disorders such as plantar fasciitis and tennis elbow without major complications upon its usage.

scholarly journals Effect of autologous adipose-derived mesenchymal stem cell therapy in combination with autologous platelet-rich plasma in the treatment of elbow tendinopathy

2020 ◽  
Vol 13 (6) ◽  
pp. e234592
Author(s):  
Julien Freitag ◽  
Kiran Shah ◽  
James Wickham ◽  
Abi Tenen
Keyword(s):  
Rating Scale ◽  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Cell Lineage ◽  
Clinical History ◽  
Mesodermal Cell ◽  
Mesenchymal Stem Cell Therapy ◽  
Patient Reported ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Tendinopathy is a common condition of both the athletic and general population and can be associated with significant pain and disability. The ability of mesenchymal stem cells (MSCs) to differentiate along a mesodermal cell lineage, including tenocytes, and secrete various bioactive regenerative and anti-inflammatory molecules has seen them considered as a future reparative therapy for tendinopathy. Preclinical trials with MSCs have shown promising positive functional and structural outcomes in several connective tissue related conditions. A 52-year-old male professional masters golfer presents with a clinical history of common extensor origin tendinopathy of the elbow. Subsequent formal ultrasound showed evidence of a large intrasubstance tear. The patient underwent intratendinous autologous adipose-derived MSC therapy in combination with autologous platelet-rich plasma. Following treatment, the patient reported progressive improvement as measured by the validated Numeric Pain Rating Scale and Patient-Rated Tennis Elbow Evaluation score. Repeat imaging showed successful regeneration of tendon-like tissue.

Local injection of Platelet Rich Plasma for Plantar Fasciitis

2021 ◽  
Vol 12 (3) ◽  
pp. 75-80
Author(s):  
Vishwas Sharad Phadke ◽  
Vaibhav Vinayak Antrolikar ◽  
Ajaykumar Ramlu Allamwar
Keyword(s):  
Cohort Study ◽  
Pain Relief ◽  
Plantar Fasciitis ◽  
Platelet Rich Plasma ◽  
Plantar Fascia ◽  
Local Injection ◽  
Vas Score ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Background: Plantar fasciitis can be defined as inflammation at the insertion of plantar fascia and is thought most commonly due to overuse injury. It usually presents as sharp shooting heel pain which is worse in the morning. The location of pain is usually plantar surface of the foot and pain may radiate proximally in long standing and severe cases. In mild cases of plantar fasciitis non steroidal anti-inflammatory drugs and activity modification may be sufficient. Severe cases may require interventions such as night splints and orthotic devices which works by reducing loading of plantar fascia. Recently local injection of autologous platelet rich plasma is used by many researchers with promising results. Aims and Objectives: This prospective cohort study was undertaken to analyze the functional and clinical outcome in patients with plantar fasciitis who were treated by autologous injection of platelet rich plasma. Materials and Methods: This was a prospective cohort study conducted in department of orthopedics of a tertiary care medical college located in an urban area. The patients diagnosed to be having plantar fasciitis were included in this study on the basis of a predefined inclusion and exclusion criteria. Patients were assessed for severity of pain by the Visual Analogue Score for pain and American orthopedic foot and ankle score (AOFAS). A VAS score of 0-3 was taken as pain relief and VAS score of 4-10 was considered as no pain relief. Whereas AOFAS scores of 90-100, 80-89, 60-79 and less than 60 were taken as excellent, good, fair and poor outcome respectively. All patients were treated by local injection of autologous platelet rich plasma. The patients were followed up at 4 weeks, 8 weeks and 12 weeks. During follow up visits the pain relief was assessed by VAS and AOFAS scores. For statistical purposed SSPS 21.0 software was used and p value less than 0.05 was taken as statistically significant. Results: A total of 60 patients were included in this study out of which there were 22 (36.67%) males and 38 (63.33%) females with a M:F ratio of 1:1.72. The most common affected age group was between the age of 41-50 years (35%) followed by 51-60 years (21.67%) and 31-40 years (20%). Twenty-seven (45%) patients were either overweight or obese. A statistically significant reduction in pain was documented at the time of follow up of 4 weeks. At the end of 12 weeks 58 (96.67%) patients experienced significant pain relief and only 2 (3.33%) patients had significant pain. Also, there was statistically significant difference between AOFAS scores at the time of presentation and at 4 weeks, 8 weeks and 12 weeks follow up visits. Conclusion: Injection of autologous platelet rich plasma for chronic plantar fasciitis is found to have promising results in terms of pain relief (reduced VAS score) and functional outcome (Improvement in AOFAS score).

scholarly journals Efficacy, safety and tolerability of autologous platelet rich plasma injection in the treatment of lateral epicondylitis

2019 ◽  
Vol 5 (6) ◽  
pp. 1121
Author(s):  
Kavyansh Bhan ◽  
Randhir Kenjle
Keyword(s):  
Performance Index ◽  
Statistical Difference ◽  
Platelet Rich Plasma ◽  
Lateral Epicondylitis ◽  
Base Line ◽  
The Novel ◽  
Methyl Prednisolone ◽  
Plasma Injection ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

<p class="abstract"><strong>Background:</strong> To evaluate the effects of platelet-rich plasma (PRP) infiltration in patients with lateral epicondylitis of the elbow.</p><p class="abstract"><strong>Methods:</strong> A randomized, prospective study on 60 patients with lateral epicondylitis of the elbow was conducted at Ruby Hall Clinic, Pune. The patients were randomized and evaluated after receiving infiltration of three milliliters of PRP, or methyl prednisolone. The base-line evaluation was done using visual analog score (VAS) and modified Mayo performance index for elbow (MAYO). Re-evaluation was after 1 and 6 months of the procedure. Statistical analysis was done using independent t-test.<strong></strong></p><p class="abstract"><strong>Results:</strong> After 6 months of treatment with PRP, patients with lateral epicondylitis had a statistically significant improvement in their VAS (p&lt;0.05) in contrast to steroid. However, no statistical difference in modified Mayo performance index was found between the two groups at 1 and 6 months after intervention.</p><p><strong>Conclusions:</strong> Treatment of patients with lateral epicondylitis with PRP reduces pain and is better tolerated than steroid therapy. Thus, the novel PRP therapy can be considered as a primary approach to treat patients of lateral epicondylitis conservatively. </p>

scholarly journals Autologous platelet rich plasma versus corticosteroid injection for chronic plantar fasciitis: a prospective controlled randomized comparative clinical study

2018 ◽  
Vol 6 (5) ◽  
pp. 1594 ◽  
Author(s):  
Sachin Upadhyay ◽  
Vijendra Damor
Keyword(s):  
Plantar Fasciitis ◽  
Platelet Rich Plasma ◽  
Corticosteroid Injection ◽  
Primary Objective ◽  
Control Group ◽  
Base Line ◽  
Autologous Platelet Rich Plasma ◽  
American Orthopaedic ◽  
Autologous Platelet

Background: Primary objective was to evaluate and compare the effectiveness of autologous platelet rich plasma (PRP) and steroid injections in chronic cases of plantar fasciitis.Methods: The present study was a prospective cohort study; 140 consecutive patients with chronic plantar fasciitis were enrolled and randomized in two groups: One receives the Platelet rich plasma (PRP) therapy (study group) and another receiving corticosteroid injection (control group). The outcomes in both groups are then evaluate and compared using visual analogue scale (VAS) and American Orthopaedic foot and Ankle Society (AOFAS) scale at 1month, 3month and 6 month post injection. The level of significance was set at p <0.05.Results: Prospective data was collected of 140 heels. The average follow up duration was about 6 months. The score on VAS scale and AOFAS improved from base line for both group but the patients received PRP therapy had a statistically significant (p<0.05) reduction in pain and improved AOFAS score at last follow up. No adverse complications were reported.Conclusions: The result of present study showed that the PRP therapy has potential to reduce pain and improve the functional outcome in cases of chronic planter fasciitis. It was found to be more effective and significantly better than corticosteroid injection.

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