Determining Maximal Tolerable Aerobic Training Intensity in the Acute Phase after Stroke: a Novel Dose Ranging Trial Protocol

Objective. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and aerobic exercise improves FMD in heart failure patients. The aim of this meta-analysis is to quantify the effect of aerobic training intensity on FMD in patients with heart failure. Background. A large number of studies now exist that examine endothelial function in patients with heart failure. We sought to add to the current literature by quantifying the effect of the aerobic training intensity on endothelial function. Methods. We conducted database searches (PubMed, Embase, ProQuest, and Cochrane Trials Register to June 30, 2016) for exercise based rehabilitation trials in heart failure, using search terms exercise training, endothelial function, and flow-mediated dilation (FMD). Results. The 13 included studies provided a total of 458 participants, 264 in intervention groups, and 194 in nonexercising control groups. Both vigorous and moderate intensity aerobic training significantly improved FMD. Conclusion. Overall both vigorous and moderate aerobic exercise training improved FMD in patients with heart failure.

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The effect of cannabidiol on simulated car driving performance: A randomised, double‐blind, placebo‐controlled, crossover, dose‐ranging clinical trial protocol

Human Psychopharmacology Clinical and Experimental ◽

10.1002/hup.2749 ◽

2020 ◽

Vol 35 (5) ◽

Author(s):

Danielle McCartney ◽

Melissa J. Benson ◽

Anastasia S. Suraev ◽

Christopher Irwin ◽

Thomas R. Arkell ◽

...

Keyword(s):

Clinical Trial ◽

Driving Performance ◽

Trial Protocol ◽

Double Blind ◽

Double Blind Placebo ◽

Clinical Trial Protocol ◽

Dose Ranging ◽

Car Driving

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Aerobic Exercise-Induced Changes in Cardiorespiratory Fitness in Breast Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis

Cancers ◽

10.3390/cancers12082240 ◽

2020 ◽

Vol 12 (8) ◽

pp. 2240

Author(s):

Guilherme Maginador ◽

Manoel E. Lixandrão ◽

Henrique I. Bortolozo ◽

Felipe C. Vechin ◽

Luís O. Sarian ◽

...

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Aerobic Exercise ◽

Usual Care ◽

Cardiorespiratory Fitness ◽

Aerobic Training ◽

Meta Analysis ◽

Moderate Intensity ◽

Training Intensity ◽

Vigorous Intensity

While performing aerobic exercise during chemotherapy has been proven feasible and safe, the efficacy of aerobic training on cardiorespiratory fitness (CRF) in women with breast cancer undergoing chemotherapy has not yet been systematically assessed. Therefore, the objective of this work was to determine (a) the efficacy of aerobic training to improve CRF; (b) the role of aerobic training intensity (moderate or vigorous) on CRF response; (c) the effect of the aerobic training mode (continuous or interval) on changes in CRF in women with breast cancer (BC) receiving chemotherapy. A systematic review and meta-analysis were conducted as per PRISMA guidelines, and randomized controlled trials comparing usual care (UC) and aerobic training in women with BC undergoing chemotherapy were eligible. The results suggest that increases in CRF are favored by (a) aerobic training when compared to usual care; (b) vigorous-intensity aerobic exercise (64–90% of maximal oxygen uptake, VO2max) when compared to moderate-intensity aerobic exercise (46–63% of VO2max); and (c) both continuous and interval aerobic training are effective at increasing the VO2max. Aerobic training improves CRF in women with BC undergoing chemotherapy. Notably, training intensity significantly impacts the VO2max response. Where appropriate, vigorous intensity aerobic training should be considered for women with BC receiving chemotherapy.

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Standardization description of dose-ranging trial protocol

Controlled Clinical Trials ◽

10.1016/0197-2456(92)90172-v ◽

1992 ◽

Vol 13 (5) ◽

pp. 430-431

Author(s):

Jean-Pierre Boissel ◽

Isabelle Durieu ◽

Pascal Girard

Keyword(s):

Trial Protocol ◽

Dose Ranging

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Kvalita života nemocných s chronickou ischemickou chorobou srdeční: Efekt tříměsíčního kombinovaného vytrvalostního/silového tréninku

Studia sportiva ◽

10.5817/sts2010-2-12 ◽

2010 ◽

Vol 4 (2) ◽

pp. 103-108

Author(s):

Ivan Janský ◽

Jiří Jančík ◽

Jitka Tomíčková ◽

Jaroslava Pochmonová ◽

Petr Dobšák ◽

...

Keyword(s):

Treatment Satisfaction ◽

Aerobic Training ◽

Peak Exercise ◽

Training Phase ◽

Training Intensity ◽

Seattle Angina Questionnaire ◽

Physical Limitations ◽

Load Intensity ◽

Disease Perception

83 patients (men) with stable chronic coronary disease (mean age 62 ± 9 years, mean body weight 86± 11 kg, mean height 177 ± 6 cm, mean ejection fraction of left ventricle 47± 8%) were examined before and aft er three months lasting aerobic training combined with stregth components . Before the training period symptom-limited spiroergometry was provided. Spiroergometry was applied for the evaluation of anaerobic threshold to decide on the aerobic training intensity. Load intensity for the strength training phase was determined by the method of 1-RM (30-60%). Th e training (exercise unit) was performed three times a week. Th e impact on quality of life was measured using SAQ (Th e Seattle Angina Questionnaire). Th e all 5 SAQ dimensions were signifi cantly better aft er the training. Physical limitations (79,7 ± 19,0 vs. 84,9 ± 16,4*) stability of symptoms (78,2 ± 19,1 vs. 85,6 ± 16,1*) frequency of symptoms (83,5 ± 15,6 vs. 88,2 ± 14,5**), treatment satisfaction (87,8 ± 14,6 vs. 92,9 ± 11,5*), and disease perception (67,2 ± 19,7 vs. 73,8 ± 19,5**). Peak exercise oxygen uptake (VO2peak ) increased from 18,6 ± 3,1 to 19,8 ± 4,0** ml. kg-1.min-1 (*P < 0.05, ** P < 0.01, Wilcoxon).

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