Human leukocyte antigen class I and II genes associated with dipyrone-related Stevens-Johnson syndrome and severe ocular complications in a Brazilian population

2021 ◽  
Author(s):  
Tais Hitomi Wakamatsu ◽  
Mayumi Ueta ◽  
Chikara Inoue ◽  
Karita Antunes Costa ◽  
Laís Yumi Sakano ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Brazilian Population ◽  
Class I ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Leukocyte Antigen ◽  
Johnson Syndrome ◽  
Leukocyte Antigen Class I

scholarly journals Human leukocyte antigen B*0702 is protective against ocular Stevens–Johnson syndrome/toxic epidermal necrolysis in the UK population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gibran F. Butt ◽  
Ali Hassan ◽  
Graham R. Wallace ◽  
Shigeru Kinoshita ◽  
Sajjad Ahmad ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Toxic Epidermal Necrolysis ◽  
Human Leukocyte ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Leukocyte Antigen ◽  
Asian Populations ◽  
Risk Alleles ◽  
Johnson Syndrome ◽  
The Uk

AbstractStevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a disease continuum of vesiculobullous mucocutaneous reactions affecting the skin and mucous membranes including the ocular surface. Manifestations of disease range from mild dry eye to progressive conjunctival cicatrisation, limbal epithelial stem cell failure and corneal blindness. In Far Eastern and South East Asian populations where SJS/TEN is prevalent, numerous human leukocyte antigen (HLA) gene variants at the A, B and C loci have been identified as risk factors for developing SJS/TEN with severe ocular complications (SOC). By contrast, the incidence of SJS/TEN with SOC in European countries is relatively low. To date, ocular SJS/TEN risk altering alleles have not been widely investigated in European populations. In this study, we analysed the association of HLA -A, -B and -C alleles with SJS/TEN in 33 patients residing in the UK with age matched controls. The data showed statistically significant novel negative allele association with HLA-B*0702 and a trend with HLA-C*0702 in the patient group, indicating these alleles are protective. Further characterisation of protective and risk alleles in other ethnic groups is required to fully elucidate the putative role of these alleles in the susceptibility of SJS/TEN with or without severe ocular complications in patients in the UK.

Novel human leukocyte antigen class I and class II alleles identified by sequence-based typing in the Genetics of Kidneys in Diabetes (GoKinD) study population

2009 ◽  
Vol 70 (9) ◽  
pp. 747-749 ◽  
Author(s):  
Suzanne Kehoe Cordovado ◽  
Laura N. Hancock ◽  
Miyono Hendrix ◽  
Christopher N. Greene ◽  
Patricia W. Mueller
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Class Ii ◽  
Class I ◽  
Leukocyte Antigen ◽  
Study Population ◽  
Leukocyte Antigen Class I
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