scholarly journals Predictive value of tissue p53 protein expression and serum p53 antibodies in oral potentially malignant disorders: Relative to oral squamous cell carcinoma

2021 ◽  
Author(s):  
Abbas Saleem Khan ◽  
Sajjad Ahmad ◽  
Zahoor Ullah ◽  
Naveed Sadiq ◽  
Mohsina Haq ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
P53 Protein ◽  
Oral Potentially Malignant Disorders ◽  
P53 Protein Expression ◽  
P53 Antibodies ◽  
Serum P53 Antibodies ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Serum P53

Serum p53 antibodies detection in oral squamous cell carcinoma, oral potentially malignant disorders and healthy indiviuals – a multicentre study

2021 ◽  
pp. 1-13
Author(s):  
Abbas Saleem Khan ◽  
Sajjad Ahmad ◽  
Zahoor Ullah ◽  
Mohsina Haq ◽  
Muhammad Umar Farooq ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Potentially Malignant Disorders ◽  
P53 Antibodies ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Group A ◽  
Group B

Abstract Objective: To detect antibodies against p53 in serum of patients of oral squamous cell carcinoma and oral potentially malignant disorders compared to healthy individuals. Method: The descriptive cross-sectional study was conducted at the departments of Oral and Maxillofacial Surgery, Peshawar Dental College, Peshawar, Khyber College of Dentistry, Peshawar, and the Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from April2016 to March2017, and comprised serum of oral squamous cell carcinoma patients in group A, oral potentially malignant disorder patients in group B and healthy individuals in group C. Serum concentrations of anti-p53 antibodies were determined by enzyme-linked immunosorbent assay. Data was analysed using SPSS 20. Results: Of the180 subjects, there were 60(33.3%) in each of the three groups. Circulating serum p53 antibodies were detected in 59(98.3%) cases in group A, 58(96.6%) in group B and in 20(33.3%) individuals in group C (p=0.001). Conclusion: The expression of circulating p53 antibodies in serum samples of squamous cell carcinoma and oral potentially malignant disorders patients indicates the potential to be a probable candidate for being taken as a diagnostic or prognostic biomarker. Key Words: Tumour suppressor genes, TSGs, Oral squamous cell carcinoma, OSCC, Oral potentially malignant disorders, OPMDs, p53, ELISA. Continuous...

scholarly journals Detection of Helicobacter pylori in Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders at a Tertiary Care Centre in Gujarat: A Case-Control Study

2021 ◽  
Author(s):  
Himani Bhardwaj Pandya ◽  
Shivangi Patel ◽  
Rajvi Patel ◽  
Urvi Patel ◽  
Sheel Patel ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Helicobacter Pylori ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
H Pylori

Introduction: Oral squamous cell carcinoma (OSCC) contribute to 90% of cancer cases in head and neck region and entails remarkable morbidity and mortality inspite of immense research and advances. Amongst other causes, infection with Helicobacter pylori is an emerging cause of OSCC. There is still perplexity in the exact etiopathogenesis of H. pylori related oral cancer. Aim: In order to explore this much unattended area, present study was aimed to find out the association between H. pylori in premalignant disorders and OSCC. Materials and methods: A Prospective case-control Pilot study of 35 patients (11 confirmed cases of Oral squamous cell carcinoma and 24 with oral potentially malignant disorders along with 15 age and sex matched healthy control) from June 2018 - September 2018 was conducted in the Department of Microbiology, Smt. B. K. Shah Medical Institute, Piparia, Gujarat. H. pylori was detected by methods like Rapid urease test, Gram’s staining and Serology. Results: H. pylori was detected in five cases with OSCC with male predominance and mean age 45.6 yrs. All the five positive patients were severely addicted to tobacco and betel quid since decades. Tobacco was found to be the major risk of OSCC with the OD of 16.19, followed by betel quid (OD-4.56) and H. pylori infection (OD-0.83). Conclusion: The results of this pilot study do not establish a definite causal relationship between H. pylori and OSCC due to the low sample size. Study definitely offers an avenue for further work on larger populations to confirm this possible association.

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