Do Tumor Volume, Tumor Volume Ratio, Type of Nerve Sparing and Surgical Experience Affect Prostate Specific Antigen Recurrence After Laparoscopic Radical Prostatectomy? A Matched Pair Analysis

2007 ◽  
Vol 177 (5) ◽  
pp. 1771-1776 ◽  
Author(s):  
M. Ates ◽  
D. Teber ◽  
A.S. Gözen ◽  
A. Tefekli ◽  
M. Sugiono ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Tumor Volume ◽  
Specific Antigen ◽  
Volume Ratio ◽  
Matched Pair ◽  
Nerve Sparing ◽  
Surgical Experience ◽  
Matched Pair Analysis ◽  
Pair Analysis

scholarly journals Holmium laser versus thulium laser enucleation of the prostate: a matched-pair analysis from two centers

2018 ◽  
Vol 10 (8) ◽  
pp. 223-233 ◽  
Author(s):  
Giacomo Maria Pirola ◽  
Giovanni Saredi ◽  
Ricardo Codas Duarte ◽  
Lorraine Bernard ◽  
Andrea Pacchetti ◽  
...  
Keyword(s):  
Specific Antigen ◽  
Group Versus ◽  
Holmium Laser ◽  
Matched Pair ◽  
Urinary Flow ◽  
Thulium Laser ◽  
Homogeneous Groups ◽  
Matched Pair Analysis ◽  
Laser Enucleation ◽  
Pair Analysis

Background: The aim of our study was to compare perioperative and functional outcomes of two different prostatic laser enucleation techniques performed in two high-volume centers: 100 W holmium laser enucleation of the prostate (HoLEP) (Lyon, France) and 110 W thulium laser enucleation of the prostate (ThuLEP) (Varese, Italy). Materials and Methods: A nonrandomized, observational, retrospective and matched-pair analysis was performed on two homogeneous groups of 117 patients that underwent prostate laser enucleation in the HoLEP or ThuLEP centers between January 2015 and April 2017, following the classical ‘three lobes’ enucleation technique. The American Society of Anesthesiologists (ASA) score and prostate volume were the main parameters considered for matching the patients between the two groups. Patients on anticoagulant therapy, with documented detrusor hypoactivity or hyperactivity or with the finding of concurrent prostate cancer were excluded from the study. Follow up was assessed at 3, 6 and 12 months after surgery. Results: Median enucleation and morcellation time was 75.5 and 11.5 min, respectively, in the HoLEP group versus 70.5 and 12 min, respectively, in the ThuLEP group ( p = 0.001 and 0.49, respectively). Enucleated adenoma weight was comparable (44 g versus 45.6 g, p = 0.60). Energy index (3884.63 versus 4137.35 J/g, p = 0.30) and enucleation index (0.57 versus 0.6 g/min, p = 0.81) were similar in the two groups. Catheterization time was comparable (1 versus 1 day; p = 0.14). The International Prostate Symptom Score and Quality of Life score significantly decreased, as well as maximal urinary flow rate. Median prostate-specific antigen (PSA) drop 1 year after surgery was 2.1 ng/ml in the HoLEP group (−52.83%) versus 1.75 ng/ml in the ThuLEP group (−47.85%) ( p = 0.013). Conclusion: Both HoLEP (100 W) and ThuLEP (110 W) relieve lower urinary tract symptoms in a comparable way with high efficacy and safety, with negligible clinical differences.

RACIAL DIFFERENCES IN TUMOR VOLUME AND PROSTATE SPECIFIC ANTIGEN AMONG RADICAL PROSTATECTOMY PATIENTS

1999 ◽  
pp. 394-397 ◽  
Author(s):  
JUDD W. MOUL ◽  
ROGER R. CONNELLY ◽  
RENEE M. MOONEYHAN ◽  
WEI ZHANG ◽  
ISABELL A. SESTERHENN ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Racial Differences ◽  
Tumor Volume ◽  
Specific Antigen

RACIAL DIFFERENCES IN TUMOR VOLUME AND PROSTATE SPECIFIC ANTIGEN AMONG RADICAL PROSTATECTOMY PATIENTS

1999 ◽  
Vol 162 (2) ◽  
pp. 394-397 ◽  
Author(s):  
JUDD W. MOUL ◽  
ROGER R. CONNELLY ◽  
RENEE M. MOONEYHAN ◽  
WEI ZHANG ◽  
ISABELL A. SESTERHENN ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Racial Differences ◽  
Tumor Volume ◽  
Specific Antigen

scholarly journals Predictors of biochemical recurrence of prostate cancer

2017 ◽  
Vol 98 (6) ◽  
pp. 890-894 ◽  
Author(s):  
F A Guliev
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Biochemical Recurrence ◽  
Tumor Volume ◽  
Prognostic Significance ◽  
Specific Antigen ◽  
Surgical Margin ◽  
Surgical Margins ◽  
Operative Risk

Aim. To study the role of postoperative parameters in predicting the probability of development of biochemical recurrence in patients with prostate cancer with low pre-operative risk of its progression. Methods. 95 patients who underwent radical prostatectomy, were included in the study, the average age being 59.5±0.7 (44-76) years. The average levels of total and free prostate-specific antigen were 5.8±0.2 (1.71-9.9) and 1.03±0.07 (0.2-3.6) ng/ml respectively. Biochemical recurrence was defined as the level of prostate-specific antigen higher than 0.2 ng/ml after radical prostatectomy. Results. 8 (8.4%) patients during the follow-up period were diagnosed with biochemical recurrence. The average period to biochemical recurrence development was 45.8±6.7 (24-84) months. Pathomorphological examination revealed presence of tumor cells at surgical margin in 18 (18.9%) cases. Biochemical recurrence was diagnosed in 5 out of 77 (6.5%) patients with negative surgical margins and in 3 out of 18 (1.7%) patients with positive surgical margins. In our study, no correlation between the state of surgical margin and biochemical recurrence development was revealed (χ2=1.958; р=0.162). In the study group postoperative Gleason score was not prognostically significant as well (р=0.294). The average tumor volume in resected material was 11.8±1.0% (1-55%) of prostate volume (мм3). Extraprostatic extension was diagnosed in 10 (10.5%) cases. Results of univariate dispersion analysis of postoperative parameters revealed prognostic significance of tumor volume in removed specimen (р=0.007) and extracapsular extension (р=0.027). Conclusion. In our study we determined that tumor volume and extracapsular extention are independent risk factors for biochemical recurrence in prostate cancer patients with low pre-operative risk of disease progression.

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