146 POSSIBLE ROLE OF SONIC HEDGEHOG SIGNALING AND THE LINK WITH EPITHELIAL-MESENCHYMAL TRANSITION (EMT) IN RENAL CANCER PROGRESSION

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Fatma Meligy ◽  
Katsumi Shigemura ◽  
Hosny Behnsawy ◽  
Fukashi Yamamichi ◽  
Masuo Yamashita ◽  
...  
Keyword(s):  
Renal Cancer ◽  
Sonic Hedgehog ◽  
Cancer Progression ◽  
Hedgehog Signaling ◽  
Epithelial Mesenchymal Transition ◽  
Sonic Hedgehog Signaling ◽  
Mesenchymal Transition

scholarly journals Cisplatin-Induced Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Transition in Hertwig’s Epithelial Root Sheath Cells

2021 ◽  
Vol 30 (2) ◽  
pp. 115-122
Author(s):  
Hanako Ishii ◽  
Mizuki Yoshida ◽  
Hiroshi Kajiya ◽  
Satoru Matsuo ◽  
Masako Toda-Nakamura ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Epithelial Mesenchymal Transition ◽  
Sonic Hedgehog Signaling ◽  
Mesenchymal Transition ◽  
Hertwig’S Epithelial Root Sheath ◽  
Root Sheath ◽  
Sheath Cells

scholarly journals Possible Role of Sonic Hedgehog and Epithelial-Mesenchymal Transition in Renal Cell Cancer Progression

2013 ◽  
Vol 54 (8) ◽  
pp. 547 ◽  
Author(s):  
Hosny M. Behnsawy ◽  
Katsumi Shigemura ◽  
Fatma Y. Meligy ◽  
Fukashi Yamamichi ◽  
Masuo Yamashita ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Cancer Progression ◽  
Renal Cell Cancer ◽  
Renal Cell ◽  
Epithelial Mesenchymal Transition ◽  
Cell Cancer ◽  
Mesenchymal Transition

scholarly journals A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

Blood ◽  
2014 ◽  
Vol 124 (13) ◽  
pp. 2061-2071 ◽  
Author(s):  
Zhiqiang Liu ◽  
Jingda Xu ◽  
Jin He ◽  
Yuhuan Zheng ◽  
Haiyan Li ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cell Survival ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Critical Role ◽  
Myeloma Cell ◽  
Sonic Hedgehog Signaling ◽  
Key Points

Key Points CD138+ MM cells are a major source of SHH. Autocrine SHH enhances MM drug resistance.

Role of Herbal Medicine/Phyto-Therapy in Cancer Prevention by Inhibiting Epithelial-Mesenchymal Transition (EMT) Pathways

2021 ◽  
pp. 215-234
Author(s):  
Rekha Gahtori ◽  
Ashutosh Paliwal
Keyword(s):  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Raw Materials ◽  
Human Life ◽  
Developed Countries ◽  
Mesenchymal Transition ◽  
Synthetic Drugs ◽  
Extracellular Signals ◽  
Different Levels

Human life is surrounded and dependent on its environment. Human civilization is nurtured by nature as it provides raw materials that are used in the manufacturing of various essential products like medicine, food items, etc. Not only developing countries but developed countries also depend on herbal-based medications. Cancer is a global health burden. Epithelial-mesenchymal-transition (EMT) plays a key role in cancer progression and is also stimulated by different extracellular signals and could be regulated at different levels. Conventional therapies exhibit a cytotoxic effect, which encourages the development of a new approach that could be used with synthetic drugs. Phytotherapy emerged as an effective weapon against cancer. Herbal drugs directly target different signaling pathways that promote EMT and eventually lead to cancer.

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