MP35-01 ACQUIRED RESISTANCE TO TEMSIROLIMUS IN HUMAN RENAL CELL CARCINOMA ACHN CELLS IS MEDIATED BY CONSTITUTIVE ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS VIA MTORC2

Ken-ichi Harada; Hideaki Miyake; Masato Fujisawa

doi:10.1016/j.juro.2014.02.1044

MP35-01 ACQUIRED RESISTANCE TO TEMSIROLIMUS IN HUMAN RENAL CELL CARCINOMA ACHN CELLS IS MEDIATED BY CONSTITUTIVE ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS VIA MTORC2

The Journal of Urology ◽

10.1016/j.juro.2014.02.1044 ◽

2014 ◽

Vol 191 (4S) ◽

Author(s):

Ken-ichi Harada ◽

Hideaki Miyake ◽

Masato Fujisawa

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Acquired Resistance ◽

Signal Transduction Pathways ◽

Human Renal Cell Carcinoma ◽

Constitutive Activation

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985 Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by constitutive activation of signal transduction pathways through mammalian target of rapamycin complex-2

European Urology Supplements ◽

10.1016/s1569-9056(13)61463-3 ◽

2013 ◽

Vol 12 (1) ◽

pp. e985

Author(s):

K. Harada

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Acquired Resistance ◽

Mammalian Target Of Rapamycin ◽

Carcinoma Cells ◽

Signal Transduction Pathways ◽

Human Renal Cell Carcinoma ◽

Constitutive Activation

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Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2

British Journal of Cancer ◽

10.1038/bjc.2013.602 ◽

2013 ◽

Vol 109 (9) ◽

pp. 2389-2395 ◽

Cited By ~ 23

Author(s):

K Harada ◽

H Miyake ◽

M Kumano ◽

M Fujisawa

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Acquired Resistance ◽

Carcinoma Cells ◽

Signal Transduction Pathways ◽

Human Renal Cell Carcinoma ◽

Constitutive Activation

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163 ACQUIRED RESISTANCE TO TEMSIROLIMUS IN HUMAN RENAL CELL CARCINOMA CELLS IS MEDIATED BY CONSTITUTIVE ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS THROUGH MAMMALIAN TARGET OF RAPAMYCIN COMPLEX-2

The Journal of Urology ◽

10.1016/j.juro.2013.02.1543 ◽

2013 ◽

Vol 189 (4S) ◽

Author(s):

Ken-ichi Harada ◽

Hideaki Miyake ◽

Masafumi Kumano ◽

Masato Fujisawa

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Acquired Resistance ◽

Mammalian Target Of Rapamycin ◽

Carcinoma Cells ◽

Signal Transduction Pathways ◽

Human Renal Cell Carcinoma ◽

Constitutive Activation

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Acquired resistance to sunitinib in human renal cell carcinoma cells is mediated by constitutive activation of signal transduction pathways associated with tumour cell proliferation

BJU International ◽

10.1111/j.1464-410x.2012.11655.x ◽

2013 ◽

Vol 112 (2) ◽

pp. E211-E220 ◽

Cited By ~ 28

Author(s):

Iori Sakai ◽

Hideaki Miyake ◽

Masato Fujisawa

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Proliferation ◽

Tumour Cell ◽

Renal Cell ◽

Acquired Resistance ◽

Carcinoma Cells ◽

Signal Transduction Pathways ◽

Human Renal Cell Carcinoma ◽

Constitutive Activation

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983 Acquired resistance to sunitinib in human renal cell carcinoma cells is mediated by constitutive activation of signal transduction pathways associated with tumor cell proliferation

European Urology Supplements ◽

10.1016/s1569-9056(13)61461-x ◽

2013 ◽

Vol 12 (1) ◽

pp. e983

Author(s):

H. Miyake ◽

I. Sakai ◽

M. Fujisawa

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Proliferation ◽

Tumor Cell ◽

Acquired Resistance ◽

Carcinoma Cells ◽

Signal Transduction Pathways ◽

Tumor Cell Proliferation ◽

Human Renal Cell Carcinoma ◽

Constitutive Activation

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S13-6 Gateways to apoptosis : the role of the cytokine-dependent signal transduction pathways in renal cell carcinoma

The Japanese Journal of Urology ◽

10.5980/jpnjurol.95.228 ◽

2004 ◽

Vol 95 (2) ◽

pp. 228

Author(s):

Mototsugu Oya ◽

Ryuichi Mizuno ◽

Akio Horiguchi ◽

Ken Marumo ◽

Masaru Murai

Keyword(s):

Signal Transduction ◽

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Signal Transduction Pathways ◽

Dependent Signal

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451: Induction of Epithelial to Mesenchymal Transition (EMT) in Human Renal Cell Carcinoma Cells Enhanced their Bone Metastasis and Lethality in Mice

The Journal of Urology ◽

10.1016/s0022-5347(18)30704-3 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 151-151

Author(s):

Takeo Nomura ◽

Wen-Chin Huang ◽

Daqing Wu ◽

Valerie Odero-Marah ◽

Chunmeng Shi ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Bone Metastasis ◽

Cell Carcinoma ◽

Renal Cell ◽

Epithelial To Mesenchymal Transition ◽

Carcinoma Cells ◽

Human Renal Cell Carcinoma ◽

Mesenchymal Transition

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1008: Expression of Cyclooxygenase-2 (COX-2) in Human Renal Cell Carcinoma (RCCA)

The Journal of Urology ◽

10.1016/s0022-5347(18)38245-4 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 266-267

Author(s):

Sean McLaughlin ◽

Eric Wallen ◽

William K. Funkhouser ◽

Raj S. Pruthi

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Cyclooxygenase 2 ◽

Human Renal Cell Carcinoma ◽

Cox 2

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Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)68191-8 ◽

1988 ◽

Vol 263 (28) ◽

pp. 14107-14114

Author(s):

D C Shrieve ◽

E A Bump ◽

G C Rice

Keyword(s):

Renal Cell Carcinoma ◽

Cell Carcinoma ◽

Renal Cell ◽

Flow Cytometric Analysis ◽

Human Renal Cell Carcinoma ◽

Flow Cytometric ◽

Murine Fibrosarcoma

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Measurement of Progesterone Receptor in Human Renal Cell Carcinoma and Normal Renal Tissue

The Journal of Urology ◽

10.1016/s0022-5347(17)50257-8 ◽

1984 ◽

Vol 131 (1) ◽

pp. 179-179

Author(s):

M.W. McDonald ◽

A.C. Diokno ◽

J.C. Seski ◽

K.M.J. Menon

Keyword(s):

Renal Cell Carcinoma ◽

Progesterone Receptor ◽

Cell Carcinoma ◽

Renal Cell ◽

Renal Tissue ◽

Human Renal Cell Carcinoma ◽

Normal Renal Tissue

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