scholarly journals PSS1 STEVENS-JOHNSON AND RED MAN SYNDROME: A CASE REPORT ON ADVERSE DRUG REACTIONS OF SIMULTANEOUS USE OF PHENYTOIN AND VANCOMYCIN

2011 ◽  
Vol 14 (3) ◽  
pp. A53
Author(s):  
S.K. Kler
Keyword(s):  
Case Report ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Red Man Syndrome ◽  
Simultaneous Use

scholarly journals Severe Adverse Drug Reactions to Quetiapine in Two Patients Carrying CYP2D6*4 Variants: A Case Report

2021 ◽  
Vol 22 (12) ◽  
pp. 6480
Author(s):  
Céline K. Stäuble ◽  
Markus L. Lampert ◽  
Thorsten Mikoteit ◽  
Martin Hatzinger ◽  
Kurt E. Hersberger ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Case Report ◽  
Adverse Drug Reactions ◽  
Active Metabolite ◽  
Hepatic Metabolism ◽  
Cytochrome P450 3A4 ◽  
Drug Reactions ◽  
Drug Induced ◽  
Potential Impact ◽  
Intermediate Metabolizer

We report two cases of patients who developed severe adverse drug reactions including persistent movement disorders, nausea, and vertigo during treatment with quetiapine at maximum daily doses ranging between 300 and 400 mg. The extensive hepatic metabolism of quetiapine is mainly attributed to cytochrome P450 3A4 (CYP3A4). However, there is recent evidence supporting the idea of CYP2D6 playing a role in the clearance of the quetiapine active metabolite norquetiapine. Interestingly, both patients we are reporting of are carriers of the CYP2D6*4 variant, predicting an intermediate metabolizer phenotype. Additionally, co-medication with a known CYP2D6 inhibitor and renal impairment might have further affected quetiapine pharmacokinetics. The herein reported cases could spark a discussion on the potential impact of a patient’s pharmacogenetic predisposition in the treatment with quetiapine. However, further studies are warranted to promote the adoption of pharmacogenetic testing for the prevention of drug-induced toxicities associated with quetiapine.

scholarly journals A CASE OF HAEMORRHAGIC OVARIAN CYST CURED WITH HOMOEOPATHIC SIMILIMUM

2020 ◽  
pp. 385-387
Author(s):  
Aman Deep
Keyword(s):  
Case Report ◽  
Corpus Luteum ◽  
Adverse Drug Reactions ◽  
Ovarian Cyst ◽  
Surgical Intervention ◽  
Ovarian Cysts ◽  
Drug Reactions ◽  
Corpus Luteum Cyst

Haemorrhage in an ovarian cyst is very common. These cyst are known as haemorrhagic ovarian cysts (HOCs).Most of the cyst disappears spontaneously, but certain cyst requires surgical intervention. HOCs are formed because of occurrence of bleeding into a follicular or corpus luteum cyst. Allopathic system of medicines used various hormonal pills for its management which may have adverse drug reactions. Homoeopathic medicines are very helpful to manage such conditions. This article is about a case of 27 years old female who was suffering from haemorrhagic cyst. Homoeopathic medicine was given on the basis of totality of symptoms and patient cured within three months of treatment. Patient’s consent has been taken for the publication of this case report.

scholarly journals Case Report: COVID-19 Misdiagnosed as a Drug Reaction to Miltefosine

2021 ◽  
Author(s):  
Jaime A. Soto ◽  
María Isabel Méndez ◽  
Jonathan D. Berman
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Adverse Drug Reactions ◽  
Case Reports ◽  
Gastrointestinal Symptoms ◽  
Drug Reactions ◽  
Mucocutaneous Leishmaniasis ◽  
Common Etiology

We present case reports of two patients treated with miltefosine for mucocutaneous leishmaniasis whose gastrointestinal symptoms were initially diagnosed as a drug reaction and only later recognized as due to COVID-19. Gastrointestinal symptoms of COVID-19 are unusual, whereas gastrointestinal adverse drug reactions are very common. These reports exemplify that this infrequent presentation of COVID-19 is likely to be ascribed to a more common etiology such as a gastrointestinal drug reaction.

scholarly journals Hypersensitivity reaction to ofloxacin: A case report

2017 ◽  
Vol 5 (4) ◽  
pp. 75-77
Author(s):  
N S Neki
Keyword(s):  
Case Report ◽  
Infectious Diseases ◽  
Hypersensitivity Reaction ◽  
Adverse Drug Reactions ◽  
Second Generation ◽  
Gram Negative Bacteria ◽  
Drug Reactions ◽  
Gram Negative ◽  
Physiological Functions ◽  
Oral Ofloxacin

Adverse drug reactions(ADRs) are noxious and unintended occurring in doses routinly used for diagnosis, treatment, prophylaxis of disease or for modification of physiological functions. Skin is the most commonly involved organ followed by GIT system although ADRS may involve any system. Ofloxacin is a quinolone antibiotic. It is considered as second-generation fluoroquinolone. It is effective for treatment of a wide variety of infectious diseases acting against both Gram-positive and Gram-negative bacteria. We present a case of hypersensitivity reaction to oral ofloxacin. Being rarity we thought of reporting this case.

scholarly journals Influence of CYP2C19*2/*17 genotype on adverse drug reactions of voriconazole in patients after allo-HSCT: a four-case report

2017 ◽  
Vol 143 (6) ◽  
pp. 1103-1106 ◽  
Author(s):  
Sienkiewicz Beata ◽  
Urbaniak-Kujda Donata ◽  
Dybko Jarosław ◽  
Wróbel Tomasz ◽  
Wiela-Hojeńska Anna
Keyword(s):  
Case Report ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Nimesulide induced Stevens Johnson Syndrome: a case report

2017 ◽  
Vol 6 (8) ◽  
pp. 2094
Author(s):  
Shagupta A. Naikwadi ◽  
Rupali B. Jadhav
Keyword(s):  
Case Report ◽  
Supportive Care ◽  
Adverse Drug Reactions ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Over The Counter ◽  
Johnson Syndrome ◽  
Inflammatory Drugs ◽  
Prescribed Medicines ◽  
Possible Cause

Adverse drug reactions to the prescribed medicines are the major obstacles in continuation of drug treatment. Stevens- Johnson Syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction which is most commonly elicited by drugs and occasionally by infections. Common drugs associated with SJS are sulphonamide antibiotics, anticonvulsants, non- steroidal anti-inflammatory drugs (NSAIDS) and allopurinol. Nimesulide is an NSAID with analgesic and antipyretic properties. Here, we report a case of 21 years old male patient who developed Stevens Johnson Syndrome following ingestion of tablet Nimesulide. The patient was managed with parenteral corticosteroids, antibiotics, emollients, and supportive care. This case highlights the importance of Nimesulide and other NSAIDs as possible cause of SJS. Nimesulide has never been approved in countries like USA, Canada, Australia. But in India it is available as over the counter drug and is used for various indications like fever, myalgia, arthralgia. Therefore, the drugs which are banned outside India should be used with caution and practitioners should report all the adverse drug reactions to such drugs.

scholarly journals Can idiosyncratic drug reactions occur in quick succession? a case of cross sensitivity between levetiracetam and phenytoin

2017 ◽  
Vol 6 (8) ◽  
pp. 2098
Author(s):  
Chitralekha Anilkumar Nayak ◽  
Kalyani Pai Kakode ◽  
Padmanabh V. Rataboli
Keyword(s):  
Case Report ◽  
Early Detection ◽  
Adverse Drug Reactions ◽  
Prophylactic Treatment ◽  
Single Case ◽  
Idiosyncratic Drug Reactions ◽  
Drug Reactions ◽  
Diagnostic Dilemma ◽  
Single Case Report ◽  
Post Traumatic

The occurrence of adverse drug reactions (ADRs) to more than one drug in quick succession can cause diagnostic dilemma to the doctor and increased burden of suffering to the patient. We present a single case report of a 23 year old female who developed rash and agranulocytosis in quick succession as ADRs to phenytoin and levetiracetam respectively. These antiepileptic drugs (AEDs) were prescribed as prophylaxis against post traumatic seizures (PTS). Hence a proper rationale for the prophylactic treatment of PTS and pharmacovigilance for early detection of adverse drug reactions is the need of the hour.

Nimodipine-induced junctional bradycardia in an elderly patient with subarachnoid hemorrhage

2020 ◽  
Vol 21 (6) ◽  
pp. 387-392
Author(s):  
Courtney L James ◽  
Marion T Turnbull ◽  
William D Freeman
Keyword(s):  
Elderly Patient ◽  
Cytochrome P450 ◽  
Case Report ◽  
Subarachnoid Hemorrhage ◽  
Adverse Events ◽  
Clinical Outcomes ◽  
Adverse Drug Reactions ◽  
Heart Block ◽  
Drug Reactions ◽  
Cytochrome P450 3A

Subarachnoid hemorrhage is a devastating form of stroke with often detrimental outcomes for patients. Here we describe a patient with subarachnoid hemorrhage treated with nimodipine, which resulted in marked bradycardia with junctional atrioventricular heart block. Nimodipine is metabolized predominantly by the cytochrome P450 3A subfamily, and its use is often associated with adverse events, such as hypotension and bradycardia, which can be exacerbated by advanced age. Our patient had the CYP3A5*3/*3 genotype, possibly predisposing her to poor metabolism of this drug. Our case report demonstrates the potential for pharmacogenomics in patients with subarachnoid hemorrhage to help predict their response to nimodipine, minimize adverse drug reactions, and potentially individualize dosing to improve future clinical outcomes.

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