Screening of Polymer-Based Drug Delivery Vehicles Targeting Folate Receptors in Triple-Negative Breast Cancer

A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.

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Lignin-graft-PLGA drug-delivery system improves efficacy of MEK1/2 inhibitors in triple-negative breast cancer cell line

Nanomedicine ◽

10.2217/nnm-2020-0010 ◽

2020 ◽

Vol 15 (10) ◽

pp. 981-1000

Author(s):

C Ethan Byrne ◽

Carlos E Astete ◽

Manibarathi Vaithiyanathan ◽

Adam T Melvin ◽

Mahsa Moradipour ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cell Line ◽

Drug Delivery System ◽

Delivery System ◽

Triple Negative Breast Cancer ◽

Targeted Therapies ◽

Triple Negative ◽

Mesenchymal Transition

Aim: Few targeted therapies are available for triple-negative breast cancer (TNBC) patients. Here, we propose a novel alkaline-lignin-conjugated-poly(lactic- co-glycolic acid) (L-PLGA) nanoparticle drug delivery system to improve the efficacy of targeted therapies. Materials & methods: L-PLGA nanoparticles (NPs) loaded with the MEK1/2 inhibitor GDC-0623 were characterized, tested in vitro on MDA-MB-231 TNBC cell line and compared with loaded PLGA NPs. Results: Loaded L-PLGA NPs were less than half the size of PLGA NPs, had slower drug release and improved the efficacy of GDC-0623 when tested in vitro. We demonstrated that GDC-0623 reversed epithelial-to-mesenchymal transition in TNBC. Conclusion: Our findings indicate that L-PLGA NPs are superior to PLGA NPs in delivering GDC-0623 to cancer cells for improved efficacy in vitro.

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Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer

Journal of Materials Chemistry B ◽

10.1039/c9tb00433e ◽

2019 ◽

Vol 7 (23) ◽

pp. 3724-3736 ◽

Cited By ~ 8

Author(s):

Changliang Liu ◽

Houqian Gao ◽

Zijian Zhao ◽

Iman Rostami ◽

Chen Wang ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Triple Negative Breast Cancer ◽

Tumor Targeting ◽

Triple Negative ◽

Pamam Dendrimer ◽

Tat Peptide ◽

Dual Functional

A dual-functional drug delivery system based on the conjugation of PAMAM dendrimer with EBP-1 and TAT peptide was established for the therapy of triple-negative breast cancer.

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Folate-Functionalized DNA Origami for Targeted Delivery of Doxorubicin to Triple-Negative Breast Cancer

Frontiers in Chemistry ◽

10.3389/fchem.2021.721105 ◽

2021 ◽

Vol 9 ◽

Author(s):

Suchetan Pal ◽

Tatini Rakshit

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Anticancer Drug ◽

Triple Negative Breast Cancer ◽

Targeted Delivery ◽

Triple Negative ◽

Folate Receptor ◽

Dna Origami ◽

Smart Actuator

DNA origami has emerged as a versatile platform for diverse applications, namely, photonics, electronics, (bio) sensing, smart actuator, and drug delivery. In the last decade, DNA origami has been extensively pursued for efficient anticancer therapy. However, challenges remain to develop strategies that improve the targeting efficiency and drug delivery capability of the DNA origami nanostructures. In this direction, we developed folate-functionalized DNA origami that effectively targets and delivers doxorubicin (DOX), a well-known anticancer drug to the folate receptor alpha (FOLR1) expressing triple-negative breast cancer (TNBC) cells in vitro. We show that folate-functionalized DNA origami structure targets and kills FOLR1 overexpressing cells with better efficacy than nontargeted origami. We envision that this study will open up the possibility of target specific delivery of anticancer drug combinations using the versatile DNA origami nanostructures to the drug resistant cancer cells.

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