Folic acid based carbon dot functionalized stearic acid-g-polyethyleneimine amphiphilic nanomicelle: Targeted drug delivery and imaging for triple negative breast cancer

2021 ◽  
Vol 197 ◽  
pp. 111382
Author(s):  
Priyatosh Sarkar ◽  
Santanu Ghosh ◽  
Kishor Sarkar
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Folic Acid ◽  
Stearic Acid ◽  
Triple Negative Breast Cancer ◽  
Targeted Drug Delivery ◽  
Triple Negative ◽  
Carbon Dot ◽  
Targeted Drug

Ingenious pH-sensitive etoposide loaded folic acid decorated mesoporous silica-carbon dot with carboxymethyl-βcyclodextrin gatekeeper for targeted drug delivery and imaging

2018 ◽  
Vol 92 ◽  
pp. 892-901 ◽  
Author(s):  
Marziyeh Poshteh Shirani ◽  
Behzad Rezaei ◽  
Taghi Khayamian ◽  
Mohammad Dinari ◽  
Fazileh Hosseini Shamili ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Carbon Dot ◽  
Targeted Drug

scholarly journals Folic Acid – targeted Doxorubicin drug delivery system for triple-negative breast cancer treatment.

2020 ◽  
Author(s):  
Sophia Antimisiaris ◽  
Helen Lamprou ◽  
Spyridon Mourtas ◽  
Maria Mantzari ◽  
Antonia Maraziotis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Treatment

Ultrafast synthesis of stabilized gold nanoparticles using aqueous fruit extract of Limonia acidissima L. and conjugated epirubicin: targeted drug delivery for treatment of breast cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (32) ◽  
pp. 26874-26882 ◽  
Author(s):  
C. Senthil Kumar ◽  
Ayyavu Mahesh ◽  
M. Gover Antoniraj ◽  
S. Vaidevi ◽  
K. Ruckmani
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Fruit Extract ◽  
Site Specific ◽  
Targeted Drug ◽  
Limonia Acidissima ◽  
Mcf 7

Green synthesis of AuNPs using extract ofLimonia acidissimaL. as a reducing agent. Epirubicin was successfully loaded on folic acid–AuNPs. This formulation revealed better site specific delivery of epirubicin to MCF-7 cells.

Folic acid functionalized starch encapsulated green synthesized copper oxide nanoparticles for targeted drug delivery in breast cancer therapy

2020 ◽  
Vol 164 ◽  
pp. 2073-2084 ◽  
Author(s):  
Arokia Vijaya Anand Mariadoss ◽  
Kandasamy Saravanakumar ◽  
Anbazhagan Sathiyaseelan ◽  
Karthikkumar Venkatachalam ◽  
Myeong-Hyeon Wang
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Copper Oxide ◽  
Targeted Drug Delivery ◽  
Copper Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Breast Cancer Therapy ◽  
Targeted Drug

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

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