scholarly journals β-aminopropionitrile-induced Aortic Aneurysm and Dissection in Mice

2022 ◽  
Author(s):  
Hisashi Sawada ◽  
Zachary A. Beckner ◽  
Sohei Ito ◽  
Alan Daugherty ◽  
Hong S. Lu
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Aneurysm And Dissection

The Nitric Oxide Signalling Pathway in Aortic Aneurysm and Dissection

2021 ◽  
Author(s):  
Marta Toral ◽  
Andrea Fuente‐Alonso ◽  
Miguel R. Campanero ◽  
Juan Miguel Redondo
Keyword(s):  
Nitric Oxide ◽  
Aortic Aneurysm ◽  
Signalling Pathway ◽  
Aortic Aneurysm And Dissection

scholarly journals A post mortem assessment of a 25-year-old man with ascending aortic dissection and a novel MYLK variant

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Katelyn Hodge ◽  
Katherine G. Spoonamore ◽  
Christopher B. Griffith ◽  
David D. Weaver ◽  
Patricia B.S. Celestino-Soper ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Rupture ◽  
Clinical Consequence ◽  
Post Mortem ◽  
Variant Of Uncertain Significance ◽  
Pathogenic Variants ◽  
Aortic Aneurysm And Dissection

We report on the process of <em>post mortem</em> evaluation and genetic testing following the death of a 25-year-old man due to ascending aortic dissection leading to aortic rupture. Following the negative clinical testing of a 12- gene thoracic aortic aneurysm and dissection panel, research testing revealed a novel c.5732A&gt;T (p.E1911V) variant in exon 34 of the MYLK gene (NM_053025). Two likely pathogenic variants in this gene have been reported previously in individuals with familial thoracic aortic aneurysm and dissection. Given the unclear clinical consequence of the variant found in our proband, we have classified this change as a variant of uncertain significance. In addition to discussing the complexity involved in variant interpretation, we recognize the need for additional research for more accurate <em>MYLK</em> interpretation. Finally, we comment on the unique challenges of <em>post mortem</em> genetic testing.

Aortic aneurysm and dissection: normal MR imaging and CT findings after surgical repair with the continuous-suture graft-inclusion technique.

Radiology ◽  
1993 ◽  
Vol 186 (1) ◽  
pp. 195-201 ◽  
Author(s):  
N M Rofsky ◽  
J C Weinreb ◽  
E A Grossi ◽  
A C Galloway ◽  
R B Libes ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Mr Imaging ◽  
Surgical Repair ◽  
Continuous Suture ◽  
Ct Findings ◽  
Aortic Aneurysm And Dissection

Thoracic aortic-aneurysm and dissection in association with significant mitral valve disease caused by mutations in TGFB2

2013 ◽  
Vol 165 (3) ◽  
pp. 584-587 ◽  
Author(s):  
Marjolijn Renard ◽  
Bert Callewaert ◽  
Fransiska Malfait ◽  
Laurence Campens ◽  
Saba Sharif ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Aortic Aneurysm ◽  
Mitral Valve Disease ◽  
Thoracic Aortic Aneurysm ◽  
Valve Disease ◽  
Aortic Aneurysm And Dissection
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