The Nitric Oxide Signalling Pathway in Aortic Aneurysm and Dissection

2021 ◽  
Author(s):  
Marta Toral ◽  
Andrea Fuente‐Alonso ◽  
Miguel R. Campanero ◽  
Juan Miguel Redondo
Keyword(s):  
Nitric Oxide ◽  
Aortic Aneurysm ◽  
Signalling Pathway ◽  
Aortic Aneurysm And Dissection

scholarly journals Ascending aortic aneurysm and dissection in young adults with bicuspid aortic valve: Implications for echocardiographic surveillance

1998 ◽  
Vol 21 (6) ◽  
pp. 439-443 ◽  
Author(s):  
John M. Burks ◽  
Richard W. Illes ◽  
Edward C. Keating ◽  
Willem J. Lubbe
Keyword(s):  
Young Adults ◽  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Bicuspid Aortic Valve ◽  
Ascending Aortic Aneurysm ◽  
Aortic Aneurysm And Dissection

The nitric oxide-cyclic GMP signalling pathway in rat brain

1993 ◽  
Vol 32 (11) ◽  
pp. 1267-1277 ◽  
Author(s):  
Eric Southam ◽  
John Garthwaite
Keyword(s):  
Nitric Oxide ◽  
Rat Brain ◽  
Cyclic Gmp ◽  
Signalling Pathway

Aortic aneurysm and dissection

1987 ◽  
Vol 2 (5) ◽  
pp. 797-804 ◽  
Author(s):  
F. Wells
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Aneurysm And Dissection

scholarly journals Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

Circulation ◽  
2001 ◽  
Vol 104 (4) ◽  
pp. 448-454 ◽  
Author(s):  
Peter J. Kuhlencordt ◽  
Robert Gyurko ◽  
Fred Han ◽  
Marielle Scherrer-Crosbie ◽  
Thomas H. Aretz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Disease ◽  
Nitric Oxide Synthase ◽  
Aortic Aneurysm ◽  
Ischemic Heart Disease ◽  
Knockout Mice ◽  
Endothelial Nitric Oxide Synthase ◽  
Double Knockout ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals A post mortem assessment of a 25-year-old man with ascending aortic dissection and a novel MYLK variant

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Katelyn Hodge ◽  
Katherine G. Spoonamore ◽  
Christopher B. Griffith ◽  
David D. Weaver ◽  
Patricia B.S. Celestino-Soper ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Rupture ◽  
Clinical Consequence ◽  
Post Mortem ◽  
Variant Of Uncertain Significance ◽  
Pathogenic Variants ◽  
Aortic Aneurysm And Dissection

We report on the process of <em>post mortem</em> evaluation and genetic testing following the death of a 25-year-old man due to ascending aortic dissection leading to aortic rupture. Following the negative clinical testing of a 12- gene thoracic aortic aneurysm and dissection panel, research testing revealed a novel c.5732A&gt;T (p.E1911V) variant in exon 34 of the MYLK gene (NM_053025). Two likely pathogenic variants in this gene have been reported previously in individuals with familial thoracic aortic aneurysm and dissection. Given the unclear clinical consequence of the variant found in our proband, we have classified this change as a variant of uncertain significance. In addition to discussing the complexity involved in variant interpretation, we recognize the need for additional research for more accurate <em>MYLK</em> interpretation. Finally, we comment on the unique challenges of <em>post mortem</em> genetic testing.

scholarly journals Inherited Non-syndromal Thoracic Aortic Aneurysm and Dissection (TAAD) – An Unrecognised Threat

2013 ◽  
Vol 22 ◽  
pp. S230-S231
Author(s):  
E. Robertson ◽  
R. Jeremy
Keyword(s):  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Aneurysm And Dissection

Aortic aneurysm and dissection: normal MR imaging and CT findings after surgical repair with the continuous-suture graft-inclusion technique.

Radiology ◽  
1993 ◽  
Vol 186 (1) ◽  
pp. 195-201 ◽  
Author(s):  
N M Rofsky ◽  
J C Weinreb ◽  
E A Grossi ◽  
A C Galloway ◽  
R B Libes ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Mr Imaging ◽  
Surgical Repair ◽  
Continuous Suture ◽  
Ct Findings ◽  
Aortic Aneurysm And Dissection
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