A systematic review on the treatment of non-healing venous ulcers following successful elimination of superficial venous reflux

2021 ◽  
Author(s):  
Eric Goldschmidt ◽  
Kristin Schafer ◽  
Fedor Lurie
Keyword(s):  
Systematic Review ◽  
Venous Reflux ◽  
Venous Ulcers

scholarly journals 3D photography versus digital planimetry in wound measurement : a systematic review protocol

2021 ◽  
Author(s):  
Parinaz Onikzeh ◽  
◽  
Afshin Heidari ◽  
Aida Kazemi ◽  
Parisa Najjariasl ◽  
...  
Keyword(s):  
Systematic Review ◽  
Area Measurement ◽  
Wound Management ◽  
Systematic Review Protocol ◽  
Eligibility Criteria ◽  
Wound Area ◽  
Venous Ulcers ◽  
Review Protocol ◽  
Review Question ◽  
3D Photography

Review question / Objective: The aim of this study is to find whether there is concordance between two methods of wound area measurement: 3D photography and digital planimetry. Condition being studied: One of the most important factors in all types of wound management is wound measurement and two new digital techniques are : digital planimetry and 3D-photography. Eligibility criteria: the articles will be included only if the study cases would be measured by both methods of wound measurement including 3D photography and digital planimetry. patients with wound in any area of their body like diabetic ulcers, venous ulcers or burning. not models or animals.not bite or scar or bruising. without any restriction in age or gender.

scholarly journals The Role of Superficial Venous Surgery in the Management of Venous Ulcers: A Systematic Review

2008 ◽  
Vol 36 (4) ◽  
pp. 458-465 ◽  
Author(s):  
D.P.J. Howard ◽  
A. Howard ◽  
A. Kothari ◽  
L. Wales ◽  
M. Guest ◽  
...  
Keyword(s):  
Systematic Review ◽  
Venous Ulcers ◽  
Venous Surgery

scholarly journals Systematic review of topic treatment for venous ulcers

2007 ◽  
Vol 15 (6) ◽  
pp. 1163-1170 ◽  
Author(s):  
Eline Lima Borges ◽  
Maria Helena Larcher Caliri ◽  
Vanderlei José Haas
Keyword(s):  
Systematic Review ◽  
Professional Practice ◽  
Topical Treatment ◽  
Venous Return ◽  
Compression Therapy ◽  
Venous Ulcer ◽  
Evidence Based ◽  
Venous Ulcers ◽  
Wide Range ◽  
Meta Analyses

Venous ulcer patients can experience this situation for several years without achieving healing if treatment is inadequate. Evidence-based professional practice generates effective results for patients and services. This research aimed to carry out a systematic review to assess the most effective method to improve venous return and the best topic treatment for these ulcers. Studies were collected in eight databases, using the following descriptors: leg ulcer, venous ulcer and similar terms. The sample consisted of 33 primary studies and two Meta-analyses. A wide range of treatments was identified, grouped in compression therapy (54.3%) and topical treatment (45.7%). It was evidenced that compression therapy increases ulcer healing rates and should be used in patients with intact arteries. There is no consensus about the best topical treatment, although different options should be associated with compression therapy.

scholarly journals Treatment of venous ulcers with growth factors: systematic review and meta-analysis

2019 ◽  
Vol 72 (1) ◽  
pp. 200-210 ◽  
Author(s):  
Magali Rezende de Carvalho ◽  
Isabelle Andrade Silveira ◽  
Beatriz Guitton Renaud Baptista de Oliveira
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Growth Factors ◽  
Growth Factor ◽  
Randomized Clinical Trials ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Intervention Group ◽  
Complete Healing ◽  
Venous Ulcers

ABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.

A Systematic Review and Meta-Analysis of Nutritional Supplementation in Chronic Lower Extremity Wounds

2016 ◽  
Vol 15 (4) ◽  
pp. 296-302 ◽  
Author(s):  
Junna Ye ◽  
Raj Mani
Keyword(s):  
Systematic Review ◽  
Lower Extremity ◽  
Sickle Cell ◽  
Meta Analysis ◽  
Nutritional Supplementation ◽  
Cochrane Library ◽  
Similar Data ◽  
Venous Ulcers ◽  
Study Characteristics ◽  
Meta Analyses

A systematic review and meta-analyses of nutritional supplementation to treat chronic lower extremity wounds was done in order to test the premise that impaired nutrition is implicated in healing. The databases of Ovid MEDLINE, Ovid EMBASE, Cochrane Library, and EBSCO CINAHL (1972-October 2014) were searched systematically. Only randomized controlled trials in adults with chronic lower extremity wounds were included. Both topical and systemic routes of supplementing nutrition were considered. The primary outcome was wound healing. Study characteristics, outcomes, and risk of bias were extracted by trained researchers and confirmed by the principal investigator. Twenty-three of 278 (8.3%) retrieved articles met the inclusion criteria and were selected. Most of the studies were of unclear or low risk. Overall, nutritional supplementation was favorable (risk ratio [RR] = 1.44, 95% confidence interval [CI] = 1.25-1.66). The systemic route was marginally better than the topical one (RR = 1.51, 95% CI = 1.36-1.67; RR = 1.14, 95% CI = 0.96-1.36, respectively). For venous ulcers, the data showed nutritional supplementation to be significantly beneficial compared to placebo (RR = 1.44, 95% CI = 1.31-1.59). Similar data were found for diabetic foot and sickle cell ulcers (RR = 1.17, 95% CI = 0.93-1.47; RR = 1.56, 95% CI = 0.94-2.60, respectively). These data permit the inferences that nutritional supplementation in the populations studied showed significant benefits in the healing of venous ulcers and tendency (nonsignificant trends) in the healing of diabetic and sickle cell ulcers.

scholarly journals The use of medicinal plants in venous ulcers: a systematic review with meta-analysis

2017 ◽  
Vol 14 (6) ◽  
pp. 1019-1024 ◽  
Author(s):  
Anderson L Freitas ◽  
Carla A Santos ◽  
Carlos AS Souza ◽  
Marco AP Nunes ◽  
Ângelo R Antoniolli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Medicinal Plants ◽  
Meta Analysis ◽  
Venous Ulcers

scholarly journals The Role of Superficial Venous Surgery in the Management of Venous Ulcers: A Systematic Review

2008 ◽  
Vol 48 (4) ◽  
pp. 1066
Author(s):  
D.P.J. Howard ◽  
A. Howard ◽  
A. Kothari ◽  
L. Wales ◽  
M. Guest ◽  
...  
Keyword(s):  
Systematic Review ◽  
Venous Ulcers ◽  
Venous Surgery

scholarly journals Systematic review and meta-analysis of surgical interventions versus conservative therapy for venous ulcers

2014 ◽  
Vol 60 (2) ◽  
pp. 60S-70S.e2 ◽  
Author(s):  
Karen F. Mauck ◽  
Noor Asi ◽  
Chaitanya Undavalli ◽  
Tarig A. Elraiyah ◽  
Mohammed Nabhan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Conservative Therapy ◽  
Meta Analysis ◽  
Surgical Interventions ◽  
Venous Ulcers

Pharmacological adjuncts for chronic venous ulcer healing: a systematic review

2015 ◽  
Vol 31 (5) ◽  
pp. 356-365 ◽  
Author(s):  
Lavanya Varatharajan ◽  
Ankur Thapar ◽  
Tristan Lane ◽  
Alex B Munster ◽  
Alun Huw Davies
Keyword(s):  
Systematic Review ◽  
Ulcer Healing ◽  
Venous Ulcer ◽  
Adjunctive Treatment ◽  
Current Evidence ◽  
Pharmacological Agents ◽  
Venous Ulcers ◽  
Cochrane Reviews ◽  
Significant Difference ◽  
Randomised Controlled

Background The aim of this study was to systematically review the current evidence and determine whether there is a clinical benefit for using pharmacological agents as adjunctive treatment for chronic venous ulcers. Method A systematic review of the MEDLINE and EMBASE (from 1 January 1947 through 15 August 2013) and Cochrane databases (from inception through 15 August 2013) was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were all randomised controlled trials investigating pharmacological adjuncts for the treatment of venous ulcers with a minimum sample size of 20 patients for each treatment arm. Results Ten relevant articles were identified; one pilot randomised controlled trial and four Cochrane reviews were included. Pentoxifylline, aspirin, sulodexide, mesoglycan, flavonoids, thromboxane A2 antagonist (ifetroban), zinc, prostaglandin and prostacyclin analogues were the drugs reviewed. Pentoxifylline was found to be more effective than placebo in terms of complete ulcer healing or in causing a significant improvement (greater than 60% reduction in ulcer size) (RR 1.70, 95% CI 1.30 to 2.24). Aspirin and flavonoids show potential to be effective adjuncts but methodological shortcomings and issues with bias limit the validity of results from trials involving each of these drugs, respectively. There was no significant difference between placebo and Ifetroban and likewise pooled results from trials investigating sulodexide and zinc showed no benefit in comparison to placebo. Conclusion Many systemic pharmacological agents have been investigated as adjuncts to venous ulcer healing; however, pentoxifylline (400 mg, three times a day) is currently the only drug that has promising evidence to support its use. Other compounds are in early stage research.

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