The use of medicinal plants in venous ulcers: a systematic review with meta-analysis

Knowledge of medicinal plants is not only one of the main components in the structure of knowledge in local medical systems but also one of the most studied resources. This study uses a systematic review and meta-analysis of a compilation of ethnobiological studies with a medicinal plant component and the variable of gender to evaluate whether there is a gender-based pattern in medicinal plant knowledge on different scales (national, continental, and global). In this study, three types of meta-analysis are conducted on different scales. We detect no significant differences on the global level; women and men have the same rich knowledge. On the national and continental levels, significant differences are observed in both directions (significant for men and for women), and a lack of significant differences in the knowledge of the genders is also observed. This finding demonstrates that there is no gender-based pattern for knowledge on different scales.

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Treatment of venous ulcers with growth factors: systematic review and meta-analysis

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2017-0865 ◽

2019 ◽

Vol 72 (1) ◽

pp. 200-210 ◽

Cited By ~ 6

Author(s):

Magali Rezende de Carvalho ◽

Isabelle Andrade Silveira ◽

Beatriz Guitton Renaud Baptista de Oliveira

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Growth Factors ◽

Growth Factor ◽

Randomized Clinical Trials ◽

Platelet Rich Plasma ◽

Meta Analysis ◽

Intervention Group ◽

Complete Healing ◽

Venous Ulcers

ABSTRACT Objective: To identify evidence about the effects of growth factor application on venous ulcer healing. Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references. Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p <0.05). Most of the studies were classified as moderate risk of bias. Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.

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A Systematic Review and Meta-Analysis of Nutritional Supplementation in Chronic Lower Extremity Wounds

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734616674624 ◽

2016 ◽

Vol 15 (4) ◽

pp. 296-302 ◽

Cited By ~ 10

Author(s):

Junna Ye ◽

Raj Mani

Keyword(s):

Systematic Review ◽

Lower Extremity ◽

Sickle Cell ◽

Meta Analysis ◽

Nutritional Supplementation ◽

Cochrane Library ◽

Similar Data ◽

Venous Ulcers ◽

Study Characteristics ◽

Meta Analyses

A systematic review and meta-analyses of nutritional supplementation to treat chronic lower extremity wounds was done in order to test the premise that impaired nutrition is implicated in healing. The databases of Ovid MEDLINE, Ovid EMBASE, Cochrane Library, and EBSCO CINAHL (1972-October 2014) were searched systematically. Only randomized controlled trials in adults with chronic lower extremity wounds were included. Both topical and systemic routes of supplementing nutrition were considered. The primary outcome was wound healing. Study characteristics, outcomes, and risk of bias were extracted by trained researchers and confirmed by the principal investigator. Twenty-three of 278 (8.3%) retrieved articles met the inclusion criteria and were selected. Most of the studies were of unclear or low risk. Overall, nutritional supplementation was favorable (risk ratio [RR] = 1.44, 95% confidence interval [CI] = 1.25-1.66). The systemic route was marginally better than the topical one (RR = 1.51, 95% CI = 1.36-1.67; RR = 1.14, 95% CI = 0.96-1.36, respectively). For venous ulcers, the data showed nutritional supplementation to be significantly beneficial compared to placebo (RR = 1.44, 95% CI = 1.31-1.59). Similar data were found for diabetic foot and sickle cell ulcers (RR = 1.17, 95% CI = 0.93-1.47; RR = 1.56, 95% CI = 0.94-2.60, respectively). These data permit the inferences that nutritional supplementation in the populations studied showed significant benefits in the healing of venous ulcers and tendency (nonsignificant trends) in the healing of diabetic and sickle cell ulcers.

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Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis

BMJ Open Science ◽

10.1136/bmjos-2020-100064 ◽

2020 ◽

Vol 4 (1) ◽

pp. e100064

Author(s):

Dereje Nigussie ◽

Belete Adefris Legesse ◽

Gail Davey ◽

Abebaw Fekadu ◽

Eyasu Makonnen

Keyword(s):

Systematic Review ◽

Wound Healing ◽

Medicinal Plants ◽

Literature Review ◽

Plant Species ◽

Systematic Literature Review ◽

Meta Analysis ◽

Registration Number ◽

Anti Inflammatory

ObjectivesMedicinal plants are used globally as alternative medicines in the management of a range of disease conditions and are widely accepted across differing societies. Ethiopia hosts a large number of plant species (>7000 higher plant species), of which around 12% are thought to be endemic, making it a rich source of plant extracts potentially useful for human health. The aim of this review is to evaluate Ethiopian medicinal plants for their anti-inflammatory, wound healing, antifungal or antibacterial activities.Methods and analysisThe guidance of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) statement will be used. This review will consider all controlled studies of anti-inflammatory and wound healing properties (both in vivo and in vitro) and in vitro anti-infective properties of medicinal plants found in Ethiopia. Data sources will be EMBASE, PubMed/Medline, Scopus and Google Scholar. Guidance documents on good in vitro methods and checklists for reporting in vitro studies will be used for quality assessment of in vitro studies. The risk of bias tool for animal intervention studies (the SYRCLE RoB tool) will be used to assess the validity of studies. The main outcomes will be percent inhibition of inflammation, time of epithelisation and tissue tensile strength in wounds and microbial growth inhibition.Ethics and disseminationThe findings of this systematic review will be disseminated by publishing in a peer-reviewed journal and via conference presentations. Ethical clearance was obtained from the Brighton and Sussex Medical School, Research Governance & Ethics Committee (RGEC) and Addis Ababa University, College of Health Science, Institutional Review Board.PROSPERO registration numberThis systematic literature review has been registered with PROSPERO (registration number CRD42019127471).

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Systematic review and meta-analysis of surgical interventions versus conservative therapy for venous ulcers

Journal of Vascular Surgery ◽

10.1016/j.jvs.2014.04.059 ◽

2014 ◽

Vol 60 (2) ◽

pp. 60S-70S.e2 ◽

Cited By ~ 29

Author(s):

Karen F. Mauck ◽

Noor Asi ◽

Chaitanya Undavalli ◽

Tarig A. Elraiyah ◽

Mohammed Nabhan ◽

...

Keyword(s):

Systematic Review ◽

Conservative Therapy ◽

Meta Analysis ◽

Surgical Interventions ◽

Venous Ulcers

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The vasodilatory effects of medicinal herbs on the cardiovascular system: A systematic review

Journal of Herbmed Pharmacology ◽

10.34172/jhp.2021.43 ◽

2021 ◽

Vol 10 (4) ◽

pp. 367-374

Author(s):

Nasrollah Moradifar ◽

Ali Asghar Kiani ◽

Navid Bakhtiari ◽

Morteza Amraei ◽

Arash Amin

Keyword(s):

Systematic Review ◽

Blood Pressure ◽

Medicinal Plants ◽

Essential Oil ◽

High Blood Pressure ◽

Meta Analysis ◽

Ethanolic Extract ◽

Extraction Methods ◽

Medicinal Herbs ◽

Herbal Remedies

Vasodilators are drugs that induce or start the widening of blood vessels and are commonly applied to treat disorders with irregularly high blood pressure, including hypertension, congestive heart failure, and angina. The present study aims to systematically review the studies on the vasodilation effects of medicinal herbs. The study was done according to the 06- Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-Analysis Facility (SyRF) database. Various English databases, such as Scopus, PubMed, Web of Science, EMBASE, and Google Scholar, were used to find publications about the vasodilation effects of medicinal herbs with no date limitation. The searched terms and keywords words were: "medicinal herbs", "medicinal plants", "vasodilator", "vasorelaxant", "hypertension", "high blood pressure", "vasodilation", "extract", "essential oil". Out of 1820 papers (up to 2020), 31 papers met the inclusion criteria and were reviewed. The most important medicinal plants with vasodilation/vasorelaxant activity belonged to the family Asteraceae (19.4%) followed by Zingiberaceae (9.7%). Aerial parts (30.5%), leaves (30.5%), followed by roots (11.1%) were the most common parts used in the studies. The findings showed that ethanolic extract (33.3%), followed by aqueous extract (22.2%) and methanolic extract (19.4%) was the frequency used extraction methods, whereas the essential oil (13.9%) and hydroalcoholic extract (8.3%) were the second most used herbal remedies. The results of the current review study revealed that the plant vasodilatory agents were might be used as an alternative and complementary source to treat hypertension as they had lower important toxicity. Nevertheless, more investigations, particularly clinical trials, are needed to clear this suggestion.

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Repellent And Larvicidal Activity Of Thai Medicinal Plants Against Mosquitoes: A Systematic Review And Meta-Analysis

Value in Health ◽

10.1016/j.jval.2017.08.1705 ◽

2017 ◽

Vol 20 (9) ◽

pp. A681

Author(s):

S Saokaew ◽

I Kiatsomboon ◽

M Piromyaporn ◽

N Sivasupaporn ◽

P Pusparajah ◽

...

Keyword(s):

Systematic Review ◽

Medicinal Plants ◽

Larvicidal Activity ◽

Meta Analysis ◽

Thai Medicinal Plants

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A systematic review with meta-analysis on the antihypertensive efficacy of Nigerian medicinal plants

Journal of Ethnopharmacology ◽

10.1016/j.jep.2021.114342 ◽

2021 ◽

pp. 114342

Author(s):

Mansurah A. Abdulazeez ◽

Suleiman Alhaji Muhammad ◽

Yusuf Saidu ◽

Abdullahi B. Sallau ◽

Auwalu A. Arzai ◽

...

Keyword(s):

Systematic Review ◽

Medicinal Plants ◽

Meta Analysis ◽

Antihypertensive Efficacy

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Evaluation of Indonesian Anti-obesity Traditional Medicinal Plants: A Systematic Review and Meta-analysis on Pancreatic Lipase Inhibition Activity

10.21203/rs.3.rs-885615/v1 ◽

2021 ◽

Author(s):

Hasim Hasim ◽

Didah Nur Faridah ◽

Frendy Ahmad Afandi ◽

Eka Nurul Qomaliyah

Keyword(s):

Systematic Review ◽

Medicinal Plants ◽

Pancreatic Lipase ◽

Data Extraction ◽

Meta Analysis ◽

Analysis Data ◽

Psidium Guajava ◽

Pancreatic Lipase Inhibition ◽

Lipase Inhibition

Abstract BackgroundResearches and publication discussing performance of medicinal plants as anti-obesity have proliferated in recent years. In the view of ethnopharmacology, empiric evidence of Indonesian medicinal plants in management of obesity is widely accepted. In attempt to find anti-obesity agent, it is evidenced that the disorder can be resolved through inhibition of pancreatic lipase since the mechanism allowed to retard absorption of fat into cells. This current work aimed to screen Indonesian medicinal plants by using ethnopharmacology and meta-analysis approaches, emphasizing their ability to deal with obesity via pancreatic lipase inhibition. MethodsThe study followed two stages, i.e. systematic review and meta-analysis. Data from 6 scientific (Scopus, Science Direct, Proquest, Ebsco, Cengage Library and Emerald) were collected, screened according to inclusion and exclusion criteria. The eligibility of the trials was determined according to criteria as follows: (1) design for lipase inhibition experiments; (2) population in all researches using in vitro protocols for antiobesity in last 10 years; (3) intervention for comparison between lipase inhibition IC50 properties of selected medicinal plants and orlistat; and (4) data adequacy enabling to estimate the standardized mean difference (SMD) and the corresponding 95% confidence interval (CI). Further, all published papers we reviewed were written in English. Furthermore, steps of meta-analysis were performed on the selected data. Extraction of data in these articles collected number of samples, average values and standard deviation of IC50. The values focused on IC50 of samples in inhibiting lipase activities performed by plant extracts and orlistat as control. ResultA total 10 selected data meet the inclusion criteria. Morever these plant can be found and common as traditional medicine plant in Indonesia ConclusionAs the results, there were top 10 anti-obesity medicinal plants as follows: i.e. kelor (Moringa oleifera) leaves, kemangi (Ocimum basilicum) leaves, asam jawa (Tamarindus indica) leaves, asam gelugur (Garcinia atroviridis) fruit, lengkuas (Alpinia galanga) rhizome, and kencur (Kaempferia galanga) rhizome, kumis kucing (Orthosipon aristatus) leaves, jambu biji leaves (Psidium guajava leavaes), serai wangi (Cymbopogon nardus) and kayu secang (Caesalpinia sappan).

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Cost and effectiveness of Platelet Rich Plasma in the healing of varicose ulcer: Meta-analysis

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2018-0981 ◽

2020 ◽

Vol 73 (4) ◽

Author(s):

Beatriz Guitton Renaud Baptista de Oliveira ◽

Magali Rezende de Carvalho ◽

Andrea Pinto Leite Ribeiro

Keyword(s):

Systematic Review ◽

Clinical Studies ◽

Cost Minimization ◽

Platelet Rich Plasma ◽

Meta Analysis ◽

Cost Minimization Analysis ◽

Venous Ulcers ◽

Varicose Ulcer ◽

The Cost

ABSTRACT Objectives: to analyze the evidence on the cost and effectiveness of Plaque Rich Plasma in the treatment of venous ulcers compared to other topical therapies. Methods: systematic review, with search in the databases: COCHRANE, EMBASE, MEDLINE via PubMed, LILACS, CINAHL, SCOPUS, without temporal cut and in the English, Portuguese and Spanish languages. Results: fifteen articles were included, a cost-minimization analysis showed that the cost of Plaque Rich Plasma is € 163.00 ± 65.90, slightly higher than the cost of standard dressing. Regarding effectiveness, the results of the studies associated with the meta-analysis suggest a tendency that Plaque Rich Plasma is effective in the healing of venous ulcers. Conclusions: it is concluded that there are few studies about the cost of Platelet Rich Plasma and this product tends to be effective in the healing of venous ulcers. However, more controlled and randomized clinical studies are necessary in order to establish a stronger recommendation.

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