Analysis of MMP-7 and TIMP-2 gene polymorphisms in coronary artery disease and myocardial infarction: A Turkish case-control study

Abstract Background Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors. Methods We conducted this study to evaluate the associations between tagSNPs in the C3 gene locus and the CAD susceptibility and lipid levels in the Chinese population. A hospital-based case-control study, including 1017 subjects (580 CAD patients and 437 non-CAD controls), was conducted. TagSNPs in the C3 gene were searched and genotyped by using the polymerase chain reaction-ligase detection reaction method. Results The C3 levels were positively associated with the low-density lipoprotein cholesterol (LDL-C) levels (r = 0.269, P = 0.001). Compared with those in controls, the serum C3 levels in CAD patients were significantly higher (Control: 0.94 + 0.14 g/l; CAD: 1.10 + 0.19 g/l, P < 0.001). No significant differences in genotype or allele frequencies were observed between CAD patients and controls. The minor T allele of rs2287848 was associated with low apolipoprotein A1 (ApoA1) levels in controls (Bonferroni corrected P, Pc = 0.032). Linkage disequilibrium and haplotype analysis established two haplotype blocks (Block1: rs344555-rs2277984, Block 2: rs2287848-rs11672613) and six haplotypes. No significant associations between haplotypes and the risk of CAD were observed (all Pc > 0.05). Conclusions The results revealed that C3 gene polymorphisms were associated with the lipid levels, but not CAD susceptibility in the Chinese population.

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Association of the ATG9B gene polymorphisms with coronary artery disease susceptibility: A case-control study

Journal of Cardiovascular and Thoracic Research ◽

10.15171/jcvtr.2019.19 ◽

2019 ◽

Vol 11 (2) ◽

pp. 109-115 ◽

Cited By ~ 1

Author(s):

Mahsa Mehrabi Pour ◽

Mahboobeh Nasiri ◽

Hajar Kamfiroozie ◽

Mohammad Javad Zibaeenezhad

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Gene Polymorphisms ◽

Case Control Study ◽

Case Control ◽

Proper Function ◽

Arms Pcr ◽

Increased Risk ◽

Artery Disease ◽

Control Study

Introduction: Endothelial nitric oxide synthase (eNOS), the main regulator of cardiac cell functioning, is regulated post-transcriptionally by autophagy-related 9B (ATG9B) gene. The proper function of the heart is partly determined by the intact interaction of these molecules. The present study aimed to investigate the effects of ATG9B rs2373929 and rs7830 gene polymorphisms on the predisposition to coronary artery disease (CAD). Methods: In this hospital-based case-control study, 150 patients with CAD compared with 150 healthy subjects for the genotype distributions of rs2373929 and rs7830 polymorphisms using T-ARMS PCR and ARMS PCR, respectively. Results: Considering rs2373929 polymorphism, increased risk of CAD observed in the presence of TT genotype (OR: 3.65; 95% CI: 1.77-7.53; P < 0.001) and also in the recessive model for T allele (OR: 3.41; 95% CI: 1.76- 6.60; P < 0.001). The frequency of the T allele was higher in cases compared to controls (OR: 1.71; 95% CI: 1.24-2.28; P = 0.001). The genotype and allele frequencies of the rs7830 polymorphism did not differ between the two study groups. Conclusion: The ATG9B gene rs2373929 polymorphism might involve in the pathogenesis of the CAD and can be considered as a screening molecular marker in the subjects prone to CAD.

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Retraction Note to: Fibroblast growth factor receptor 4 polymorphisms and coronary artery disease: a case control study

Molecular Biology Reports ◽

10.1007/s11033-016-3985-z ◽

2016 ◽

Vol 43 (7) ◽

pp. 751-751

Author(s):

Qing Zhu ◽

Tongtao Liu

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Growth Factor ◽

Fibroblast Growth Factor Receptor ◽

Case Control Study ◽

Growth Factor Receptor ◽

Case Control ◽

Fibroblast Growth ◽

Artery Disease ◽

Control Study

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Association of smoking with coronary artery disease in Nepalese populations: a case control study

Toxicology Research ◽

10.1039/c9tx00083f ◽

2019 ◽

Vol 8 (5) ◽

pp. 677-685

Author(s):

Til Bahadur Basnet ◽

Cheng Xu ◽

Manthar Ali Mallah ◽

Wiwik Indayati ◽

Cheng Shi ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Case Control Study ◽

Case Control ◽

Psychosocial Risk ◽

Psychosocial Risk Factor ◽

Artery Disease ◽

Control Study

Abstract There are well-known traditional risk factors for coronary artery disease (CAD). Among them, smoking is one of the most prominent and modifiable risk factors. This study aims to determine the magnitude of smoking as a risk factor for CAD in the Nepalese population. A hospital-based age- and sex-matched case–control study was carried out with a total of 612 respondents. Bivariate analysis showed that the risk of developing CAD in ex-smokers and current smokers was higher (odds ratio (OR): 1.81 (confidence interval (CI): 1.21–2.7) and OR: 5.2 (CI: 3.4–7.97)), with p-values less than 0.004 and <0.00001, respectively, compared to the risk in never smokers. From stratified socio-demographic, cardio-metabolic, behavioural and psychosocial risk factor analysis, smoking was found to be associated with CAD in almost all subgroups. In the subsequent multivariate analysis, adjustment for socio-demographic, cardio-metabolic and psychosocial risk factors showed a steady increase in risk. However, further adjustment for behavioural risk factors (alcohol use and physical activity) showed that the risk was attenuated by 59% in current smokers. After adjusting for the covariates, current smokers and ex-smokers had an increased risk of CAD (OR: 6.64, 95% CI: 3.64–12.12, p < 0.00001; OR: 1.89, 95% CI: 1.08–3.31, p < 0.012, respectively) compared with non-smokers. In conclusion, smoking was found to increase the risk of CAD in the Nepalese population.

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