Predicting hypoglycemic drugs of type 2 diabetes based on weighted rank support vector machine

2020 ◽  
Vol 197 ◽  
pp. 105868 ◽  
Author(s):  
Xinye Wang ◽  
Yi Yang ◽  
Yitian Xu ◽  
Qian Chen ◽  
Hongmei Wang ◽  
...  
2019 ◽  
Vol 14 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Enrico Longato ◽  
Giada Acciaroli ◽  
Andrea Facchinetti ◽  
Alberto Maran ◽  
Giovanni Sparacino

Background: Many glycemic variability (GV) indices exist in the literature. In previous works, we demonstrated that a set of GV indices, extracted from continuous glucose monitoring (CGM) data, can distinguish between stages of diabetes progression. We showed that 25 indices driving a logistic regression classifier can differentiate between healthy and nonhealthy individuals; whereas 37 GV indices and four individual parameters, feeding a polynomial-kernel support vector machine (SVM), can further distinguish between impaired glucose tolerance (IGT) and type 2 diabetes (T2D). The latter approach has some limitations to interpretability (complex model, extensive index pool). In this article, we try to obtain the same performance with a simpler classifier and a parsimonious subset of indices. Methods: We analyzed the data of 62 subjects with IGT or T2D. We selected 17 interpretable GV indices and four parameters (age, sex, BMI, waist circumference). We trained a SVM on the data of a baseline visit and tested it on the follow-up visit, comparing the results with the state-of-art methods. Results: The linear SVM fed by a reduced subset of 17 GV indices and four basic parameters achieved 82.3% accuracy, only marginally worse than the reference 87.1% (41-features polynomial-kernel SVM). Cross-validation accuracies were comparable (69.6% vs 72.5%). Conclusion: The proposed SVM fed by 17 GV indices and four parameters can differentiate between IGT and T2D. Using a simpler model and a parsimonious set of indices caused only a slight accuracy deterioration, with significant advantages in terms of interpretability.


2019 ◽  
Vol 39 (1) ◽  
pp. 38-51 ◽  
Author(s):  
Neelamshobha Nirala ◽  
R. Periyasamy ◽  
Bikesh Kumar Singh ◽  
Awanish Kumar

2021 ◽  
Vol 9 (4) ◽  
pp. 316-316
Author(s):  
Chuan Wang ◽  
Taomin Zhang ◽  
Peng Wang ◽  
Xuan Liu ◽  
Liming Zheng ◽  
...  

Author(s):  
Sushma Jaiswal ◽  
Tarun Jaiswal

Introduction: The expansion of an actual diabetes judgement structure by the fascinating improvement of computational intellect is observed as a chief objective currently. Numerous tactics based on the artificial network and machine-learning procedures have been established and verified alongside diabetes datasets, which remained typically associated with the entities of Pima Indian derivation. Nevertheless, extraordinary accuracy up to 99-100% in forecasting the precise diabetes judgement, none of these methods has touched scientific presentation so far. Various tools such as Machine Learning (ML) and Data Mining are used for correct identification of diabetes. These tools improve the diagnosis process associated with T2DM. Diabetes mellitus type 2 (DMT2) is a major problem in several developing countries but its early diagnosis can provide enhanced treatment and can save several people life. Accordingly, we have to develop a structure that diagnoses type 2 diabetes. In this paper, a fuzzy expert system is proposed that present the Mamdani fuzzy inference structure (MFIS) to diagnose type 2 diabetes meritoriously. For necessary evaluation of the proposed structure, a proportional revision has been originated, that provide the anticipated structure with Machine Learning algorithms, specifically J48 Decision-tree (DT), multilayer perceptron (MLP), support-vector-machine (SVM), and Naïve- Bayes (NB), fusion and mixed fusion-based methods. The advanced fuzzy expert system (FES) and the machine learning algorithms are authenticated with actual data commencing the UCI machine learning datasets. Furthermore, the concert of the fuzzy expert structure is appraised by equating it to connected work that used the MFIS to detect the occurrence of type 2 diabetes. Objective: This survey paper presents a review of recent advances in the area of machine learning based classification models for diagnosis of diabetes. Methods: This paper presents an extensive work done in the field of machine learning based classification models for diagnosis of type 2 diabetes where modified fusion of machine learning methods are compared to the basic models i.e. Radial basis function, K-nearest neighbor, support vector machine, J48, logistic regression, classification and regression tress etc. based on training and testing. Results: Fig. 3 and Fig. 4 summarizes the result based on prediction accurateness for each classifier of training and testing. Conclusion: The fuzzy expert system is the best among its rival classifiers; SVM performs very poorly with a very low true positive rate, i.e. a very high number of positive cases misclassified as (Non-diabetic) negative. Based on the evaluation it is clear that the fuzzy expert system has the highest precision value. However, J48 is the least accurate classifier. It has the highest number of false positives relative to the other classifiers mentioned in the testing part. The results show that the fuzzy expert system has the uppermost cost for both precision and recall. Thus, it has the uppermost value for F-measure in the training and testing datasets. J48 is considered the second-best classifier for the training dataset, whereas Naïve Bayes comes in the second rank in the testing dataset.


PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0219636 ◽  
Author(s):  
Hasan T. Abbas ◽  
Lejla Alic ◽  
Madhav Erraguntla ◽  
Jim X. Ji ◽  
Muhammad Abdul-Ghani ◽  
...  

BMC Genetics ◽  
2010 ◽  
Vol 11 (1) ◽  
pp. 26 ◽  
Author(s):  
Hyo-Jeong Ban ◽  
Jee Yeon Heo ◽  
Kyung-Soo Oh ◽  
Keun-Joon Park

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