Integrated analysis of genome-wide DNA methylation and gene expression data provide a regulatory network in intrauterine growth restriction

Life Sciences ◽  
2017 ◽  
Vol 179 ◽  
pp. 60-65 ◽  
Author(s):  
Ying-xue Ding ◽  
Hong Cui
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Gene Expression Data ◽  
Regulatory Network ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Integrated Analysis ◽  
Expression Data ◽  
Intrauterine Growth ◽  
Genome Wide

scholarly journals An integrated analysis of genome‐wide DNA methylation and gene expression data in hepatocellular carcinoma

FEBS Open Bio ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 1093-1103 ◽  
Author(s):  
Xiang‐Jun Sun ◽  
Ming‐Chun Wang ◽  
Feng‐Hua Zhang ◽  
Xiao Kong
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Gene Expression Data ◽  
Integrated Analysis ◽  
Expression Data ◽  
Genome Wide

scholarly journals A Genome-Wide Integrative Association Study of DNA Methylation and Gene Expression Data and Later Life Cognitive Functioning in Monozygotic Twins

2020 ◽  
Vol 14 ◽  
Author(s):  
Mette Soerensen ◽  
Dominika Marzena Hozakowska-Roszkowska ◽  
Marianne Nygaard ◽  
Martin J. Larsen ◽  
Veit Schwämmle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Cognitive Functioning ◽  
Association Study ◽  
Gene Expression Data ◽  
Monozygotic Twins ◽  
Later Life ◽  
Expression Data ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide DNA methylation analysis in jejunum of Sus scrofa with intrauterine growth restriction

2018 ◽  
Vol 293 (4) ◽  
pp. 807-818 ◽  
Author(s):  
Yue Hu ◽  
Liang Hu ◽  
Desheng Gong ◽  
Hanlin Lu ◽  
Yue Xuan ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Intrauterine Growth Restriction ◽  
Sus Scrofa ◽  
Growth Restriction ◽  
Methylation Analysis ◽  
Intrauterine Growth ◽  
Genome Wide ◽  
Dna Methylation Analysis

scholarly journals The value of DNA methylation profiling in characterizing preeclampsia and intrauterine growth restriction

2017 ◽  
Author(s):  
Samantha L Wilson ◽  
Katherine Leavey ◽  
Brian Cox ◽  
Wendy P Robinson
Keyword(s):  
Dna Methylation ◽  
Intrauterine Growth Restriction ◽  
Late Onset ◽  
Growth Restriction ◽  
Hypertensive Disorder ◽  
Intrauterine Growth ◽  
Healthy Pregnancy ◽  
Genome Wide ◽  
Illumina Humanmethylation450 ◽  
Clinical Diagnoses

AbstractPlacental health is a key component to healthy pregnancy. Placental insufficiency (PI), inadequate nutrient delivery to the fetus, is associated with preeclampsia (PE), a maternal hypertensive disorder, and intrauterine growth restriction (IUGR), pathologically poor fetal growth. PI is more common in early-onset PE (EOPE) than late-onset PE (LOPE). However, the relationship between these disorders remains unclear. While DNA methylation (DNAm) alterations have been identified in PE and IUGR, these entities can overlap and few studies have analyzed these separately. This study aims to identify altered DNAm in EOPE, LOPE, and normotensive IUGR, validate these alterations, and use them to better understand the relationships between these related disorders.Placental samples from a discovery cohort (43 controls, 22 EOPE, 18 LOPE, 11 IUGR) and validation cohort (15 controls, 22 EOPE, 11 LOPE) were evaluated using the Illumina HumanMethylation450 array. To minimize gestational age (GA) effects, EOPE samples were compared to pre-term controls (GA <37 weeks), while LOPE and IUGR were compared to term controls (GA >37 weeks). There were 1703 differentially methylated (DM) sites (FDR<0.05, Δβ>0.1) in EOPE, 5 in LOPE, and 0 in IUGR. Of the 1703 EOPE sites, 599 were validated in the second cohort. These sites cluster samples from both cohorts into 3 distinct methylation clusters. Interestingly, LOPE samples diagnosed between 34-36 weeks with co-occurring IUGR clustered with the EOPE methylation cluster. DNAm profiling may provide an independent tool to refine clinical diagnoses into subgroups with more uniform pathology. The challenges in reproducing genome-wide DNAm studies are also discussed.

scholarly journals Multiple network algorithm for epigenetic modules via the integration of genome-wide DNA methylation and gene expression data

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiaoke Ma ◽  
Zaiyi Liu ◽  
Zhongyuan Zhang ◽  
Xiaotai Huang ◽  
Wanxin Tang
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Gene Expression Data ◽  
Expression Data ◽  
Network Algorithm ◽  
Genome Wide ◽  
Multiple Network

scholarly journals Associations between Placental Insulin-Like Growth Factor-1 Gene Expression, DNA Methylation and Intrauterine Growth Restriction

Health ◽  
2020 ◽  
Vol 12 (03) ◽  
pp. 270-280
Author(s):  
Xiaojuan Li ◽  
Baifeng Yu ◽  
Xueli Wu ◽  
Jiye Zhang ◽  
Caihong Jia ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Growth Factor ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Insulin Like Growth Factor ◽  
Intrauterine Growth

scholarly journals Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data

Oncotarget ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 3002-3017 ◽  
Author(s):  
Sandeep K. Singhal ◽  
Nawaid Usmani ◽  
Stefan Michiels ◽  
Otto Metzger-Filho ◽  
Kamal S. Saini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Dna Methylation ◽  
Gene Expression Data ◽  
Expression Data ◽  
Genome Wide
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