Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway

The role of Notch ligand, Delta-like ligand 4 (DLL4), in cancer angiogenesis—implications for therapy

European Surgery ◽

10.1007/s10353-021-00707-x ◽

2021 ◽

Author(s):

Marlena Brzozowa-Zasada

Keyword(s):

Cancer Therapy ◽

Notch Signalling ◽

Signalling Pathway ◽

Gamma Secretase ◽

Tumour Angiogenesis ◽

Notch Signalling Pathway ◽

Expression Levels ◽

Blocking Agents ◽

Anti Cancer

Summary Background It is generally accepted that angiogenesis is a complex and tightly regulated process characterized by the growth of blood vessels from existing vasculature. Activation of the Notch signalling pathway affects multiple aspects of vascular development. One of the components of the Notch signalling pathway, Delta-like ligand 4 (DLL4), has recently appeared as a critical regulator of tumour angiogenesis and thus as a promising therapeutic target. Methods This review article includes available data from peer-reviewed publications associated with the role of DLL4 in cancer angiogenesis. Searches were performed in PubMed, EMBASE, Google Scholar and Web of Science using the terms “tumour angiogenesis”, “DLL4”, “Notch signalling” and “anti-cancer therapy”. Results The survival curves of cancer patients revealed that the patients with high DLL4 expression levels had significantly shorter survival times than the patients with low DLL4 expression. Moreover, a positive correlation was also identified between DLL4 and VEGF receptorsʼ expression levels. It seems that inhibition of DLL4 may exert potent growth inhibitory effects on some tumours resistant to anti-VEGF therapies. A great number of blocking agents of DLL4/Notch signalling including anti-DLL4 antibodies, DNA vaccination, Notch antibodies and gamma-secretase inhibitors have been studied in preclinical tumour models. Conclusion DLL4 seems to be a promising target in anti-cancer therapy. Nevertheless, the careful evaluation of adverse effects on normal physiological processes in relation to therapeutic doses of anti-DLL4 drugs will be significant for advancement of DLL4 blocking agents in clinical oncology.

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Zebrafish notch signalling pathway mutants exhibit trunk vessel patterning anomalies that are secondary to somite misregulation

Developmental Dynamics ◽

10.1002/dvdy.22410 ◽

2010 ◽

Vol 239 (10) ◽

pp. 2761-2768 ◽

Cited By ~ 10

Author(s):

Christina Therapontos ◽

Neil Vargesson

Keyword(s):

Notch Signalling ◽

Signalling Pathway ◽

Notch Signalling Pathway

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Novel players in the Notch signalling pathway

Developmental Biology ◽

10.1016/j.ydbio.2007.03.082 ◽

2007 ◽

Vol 306 (1) ◽

pp. 301

Author(s):

Hugo J. Bellen ◽

Melih Acar ◽

Hamed Jafar Nejad ◽

Anchi Tien ◽

Akhila Rajan

Keyword(s):

Notch Signalling ◽

Signalling Pathway ◽

Notch Signalling Pathway

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Conservation of the Notch signalling pathway in mammalian neurogenesis

Development ◽

10.1242/dev.124.6.1139 ◽

1997 ◽

Vol 124 (6) ◽

pp. 1139-1148 ◽

Cited By ~ 31

Author(s):

J.L. Pompa de la ◽

A. Wakeham ◽

K.M. Correia ◽

E. Samper ◽

S. Brown ◽

...

Keyword(s):

Cell Fate ◽

Notch Pathway ◽

Stem Cell Differentiation ◽

Notch Signalling ◽

Signalling Pathway ◽

Notch Signalling Pathway ◽

Altered Expression ◽

Cell Fate Decisions ◽

Targeted Mutation ◽

Multiple Cell

The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not been shown. Here we show that these mutations lead to altered expression of the Notch signalling pathway homologues Hes-5, Mash-1 and Dll1, resulting in enhanced neurogenesis. Precocious neuronal differentiation is indicated by the expanded expression domains of Math4A, neuroD and NSCL-1. The RBP-Jk mutation has stronger effects on expression of these genes than does the Notch1 mutation, consistent with functional redundancy of Notch genes in neurogenesis. Our results demonstrate conservation of the Notch pathway and its regulatory mechanisms from fly to mouse, and support a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation.

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The Notch Signalling Pathway in the Development of the Mouse Placenta

Placenta ◽

10.1016/j.placenta.2008.06.004 ◽

2008 ◽

Vol 29 (8) ◽

pp. 651-659 ◽

Cited By ~ 49

Author(s):

M. Gasperowicz ◽

F. Otto

Keyword(s):

Notch Signalling ◽

Signalling Pathway ◽

Notch Signalling Pathway ◽

Mouse Placenta

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PO-081 Notch signalling pathway plays a crucial role in maintaining the cancer stem cell population in lung and colorectal cancer

10.1136/esmoopen-2018-eacr25.124 ◽

2018 ◽

Author(s):

M Novikova ◽

N Khromova ◽

V Rybko ◽

V Dugina ◽

B Kopnin ◽

...

Keyword(s):

Colorectal Cancer ◽

Stem Cell ◽

Cancer Stem Cell ◽

Cell Population ◽

Crucial Role ◽

Notch Signalling ◽

Signalling Pathway ◽

Stem Cell Population ◽

Notch Signalling Pathway ◽

Cancer Stem Cell Population

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Overexpressing microRNA-34a overcomes ABCG2-mediated drug resistance to 5-FU in side population cells from colon cancer via suppressing DLL1

The Journal of Biochemistry ◽

10.1093/jb/mvaa012 ◽

2020 ◽

Vol 167 (6) ◽

pp. 557-564

Author(s):

Zheng-Yuan Xie ◽

Fen-Fen Wang ◽

Zhi-Hua Xiao ◽

Si-Fu Liu ◽

Sheng-Lan Tang ◽

...

Keyword(s):

Colon Cancer ◽

Drug Resistance ◽

Side Population ◽

Critical Role ◽

Notch Pathway ◽

Notch Signalling ◽

Signalling Pathway ◽

Luciferase Reporter ◽

Small Subset ◽

Notch Signalling Pathway

Abstract Colon cancer side population (SP) cells are a small subset of cancer cells that have cancer stemness capacity and enhanced drug resistance. ABCG2 is a multidrug resistance-related protein in SP cells and has been demonstrated to be regulated by Notch signalling pathway. Recently, microRNAs are reported to play a critical role in SP cell fate. However, their role in ABCG2-mediated drug resistance in colon cancer SP cells remains unclear. In the current study, the different expressions of miR-552, miR-611, miR-34a and miR-5000-3p were compared within SP and non-SP cells, which were separated from human colon cancer cell lines (SW480 and LoVo). We found that miR-34a was significantly down-regulated in SP cells and that overexpressing miR-34a overcame drug resistance to 5-fluorouracil (5-FU). The luciferase reporter assay indicated that miR-34a negatively regulated DLL1, a ligand of Notch signalling pathway, via binding with 3′-untranslated region of its messenger RNA. In addition, overexpressing miR-34a overcame ABCG2-mediated resistance to 5-FU via DLL1/Notch pathway in vitro, and suppressed tumour growth under 5-FU treatment in vivo. In conclusion, our findings suggest that miR-34a acts as a tumour suppressor via enhancing chemosensitivity to 5-FU in SP cells, which provides a novel therapeutic target in chemotherapy-resistant colon cancer.

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