Association of genetic polymorphisms of CXCL12/SDF1 gene and its receptor, CXCR4, to the susceptibility and prognosis of non-small cell lung cancer

Lung Cancer ◽  
2011 ◽  
Vol 73 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Yao-Ling Lee ◽  
Wu-Hsien Kuo ◽  
Chiao-Wen Lin ◽  
Wei Chen ◽  
Wei-Erh Cheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Genetic polymorphisms and treatment response in advanced non-small cell lung cancer

Lung Cancer ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 281-288 ◽  
Author(s):  
Dan Su ◽  
Shenglin Ma ◽  
Peng Liu ◽  
Zhiming Jiang ◽  
Wangxia Lv ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Treatment Response ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Genetic Polymorphisms in the Vitamin D Pathway and Non-small Cell Lung Cancer Survival

2019 ◽  
Vol 26 (3) ◽  
pp. 1709-1715 ◽  
Author(s):  
Jinyu Kong ◽  
Xiaojie Chen ◽  
Jian Wang ◽  
Jingxin Li ◽  
Fangxiu Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Cancer Survival ◽  
Cancer Susceptibility ◽  
Small Cell ◽  
Nucleotide Polymorphisms ◽  
Small Cell Lung

Abstract Various genetic polymorphisms have been linked to lung cancer susceptibility and survival outcomes. Vitamin D (VD) regulates cell proliferation and differentiation, inhibits tumor growth and induces apoptosis. Observations from several previous studies including our own suggest that genetic polymorphisms in the VD pathway may be associated with lung cancer risk. The aim of this study is to assess if genetic polymorphisms in the VD pathway are associated with the prognosis of non-small cell lung cancer (NSCLC). Nine single nucleotide polymorphisms (SNPs) in five genes in the VD pathway were genotyped with the TaqMan assays in 542 patients with primary NSCLC, and the relationships between these SNPs and overall survival were evaluated. We found that SNP rs10741657 in the CYP2R1 gene was associated with the prognosis of NSCLC, especially in elderly patients and not being treated with chemotherapy. Some of the VD pathway-related genetic polymorphisms may influence the prognosis of NSCLC. More research is needed to further confirm the finding and test if VD supplements can be used for NSCLC treatment.

Effect of genetic polymorphisms on erlotinib pharmacokinetics and toxicity in Japanese patients with non-small cell lung cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e19104-e19104
Author(s):  
Sho Saeki ◽  
Jiichiro Sasaki ◽  
Norihiro Iwamoto ◽  
Megumi Inaba ◽  
Sunao Ushijima ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Cell Lung Cancer ◽  
Japanese Patients ◽  
Small Cell ◽  
Small Cell Lung
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