Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for
administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded
Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan
– Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic
gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was
60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4
nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR
studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator
conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.
