Pulsatile flow pump based on an iterative controlled piston pump actuator as an in-vitro cardiovascular flow model

2020 ◽  
Vol 77 ◽  
pp. 118-124 ◽  
Author(s):  
Joonyeong Kim ◽  
Youngjin Lee ◽  
Seongwook Choi ◽  
Hoijn Ha
Keyword(s):  
Pulsatile Flow ◽  
Flow Model ◽  
Piston Pump ◽  
Cardiovascular Flow ◽  
Flow Pump

scholarly journals A pulsatile flow model for in vitro quantitative evaluation of prosthetic valve regurgitation

2000 ◽  
Vol 33 (3) ◽  
pp. 341-346
Author(s):  
S. Giuliatti ◽  
L. Gallo Jr. ◽  
O.C. Almeida-Filho ◽  
A. Schmidt ◽  
J.A. Marin-Neto ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Pulsatile Flow ◽  
Prosthetic Valve ◽  
Flow Model ◽  
Valve Regurgitation

scholarly journals A Real-Time Programmable Pulsatile Flow Pump for In Vitro Cardiovascular Experimentation

2016 ◽  
Vol 138 (11) ◽  
Author(s):  
Rahul Raj Mechoor ◽  
Tyler Schmidt ◽  
Ethan Kung
Keyword(s):  
Pulsatile Flow ◽  
Low Cost ◽  
Gear Pump ◽  
Scientific Software ◽  
Flow Rates ◽  
Feedback Algorithm ◽  
Anatomic Locations ◽  
Flow Waveforms ◽  
Flow Pump

Benchtop in vitro experiments are valuable tools for investigating the cardiovascular system and testing medical devices. Accurate reproduction of the physiologic flow waveforms at various anatomic locations is an important component of these experimental methods. This study discusses the design, construction, and testing of a low-cost and fully programmable pulsatile flow pump capable of continuously producing unlimited cycles of physiologic waveforms. It consists of a gear pump actuated by an AC servomotor and a feedback algorithm to achieve highly accurate reproduction of flow waveforms for flow rates up to 300 ml/s across a range of loading conditions. The iterative feedback algorithm uses the flow error values in one iteration to modify the motor control waveform for the next iteration to better match the desired flow. Within four to seven iterations of feedback, the pump replicated desired physiologic flow waveforms to within 2% normalized RMS error (for flow rates above 20 mL/s) under varying downstream impedances. This pump device is significantly more affordable (∼10% of the cost) than current commercial options. More importantly, the pump can be controlled via common scientific software and thus easily implemented into large automation frameworks.

Effects of Heart Rate on the Pulsatile Flow Characteristics of a Stenotic Aortic Valve Model: An In Vitro Experimental Study

2020 ◽  
Vol 142 (10) ◽  
Author(s):  
Ruihang Zhang ◽  
Yan Zhang
Keyword(s):  
Heart Rate ◽  
Cardiac Output ◽  
Aortic Valve ◽  
Pressure Gradient ◽  
Pulsatile Flow ◽  
Flow Characteristics ◽  
Aortic Valve Area ◽  
Heart Rates ◽  
Cardiovascular Flow

Abstract In this paper, the characteristics of pulsatile flow past a silicone-based artificial stenotic aortic valve under varied heart rates have been studied using particle image velocimetry (PIV). Pulsatile flow waveforms were generated by a closed-loop cardiovascular flow simulator. Phase-locked PIV was employed to quantify the average and turbulent flow field information. Pressure gradient waveforms were recorded to evaluate the severity of the stenosis. Results suggest that as the heart rate increases, the peak pressure gradient across the stenotic aortic valve increases significantly under the same cardiac output. Under the same cardiac output, the aortic valve area (AVA) estimated using Gorlin equation decreases as the heart rate increases, while the trend is reversed using Hakki equation estimation. PIV results suggest that the peak systolic jet velocity downstream of the valve increases as the heart rate increases, implying a longer pressure recovery distance as heart rate increases. While the turbulence at peak systole is higher under the slower heart rate, the faster heart rate contributes to higher turbulence during the late systole and early diastole phases. Based on the comparison with no-valve cases, the differences in turbulence kinetic energy (TKE) was mainly related to the dynamics of leaflets under different heart rates. Overall, the results obtained in this study demonstrate that the hemodynamics of a stenotic aortic valve is complex, and the assessment of AS could be significantly affected by the pulsating rate of the flow.

scholarly journals In-vitro validation of 4D flow MRI measurements with an experimental pulsatile flow model

2019 ◽  
Vol 100 (1) ◽  
pp. 17-23 ◽  
Author(s):  
A. David ◽  
D. Le Touze ◽  
K. Warin-Fresse ◽  
P. Paul-Gilloteaux ◽  
F. Bonnefoy ◽  
...  
Keyword(s):  
Pulsatile Flow ◽  
Flow Model ◽  
4D Flow Mri ◽  
4D Flow ◽  
Flow Mri ◽  
Mri Measurements

scholarly journals Pressure recovery in aortic stenosis: An in vitro study in a pulsatile flow model

1992 ◽  
Vol 20 (7) ◽  
pp. 1585-1593 ◽  
Author(s):  
Wolfram Voelker ◽  
Helmut Reul ◽  
Thomas Stelzer ◽  
Anselm Schmidt ◽  
Karl R. Karsch
Keyword(s):  
Aortic Stenosis ◽  
Pulsatile Flow ◽  
Flow Model ◽  
In Vitro Study ◽  
Vitro Study ◽  
Pressure Recovery

500 An in vitro steady flow model of mitral regurgitation by three-dimensional Doppler

1999 ◽  
Vol 1 ◽  
pp. S86-S86
Author(s):  
R DESIMONE ◽  
G GLOMBITZA ◽  
C VAHL ◽  
H MEINZER ◽  
S HAGL
Keyword(s):  
Mitral Regurgitation ◽  
Steady Flow ◽  
Flow Model ◽  
Three Dimensional

A Study of Doppler Waveform Using Pulsatile Flow Model

1997 ◽  
Vol 37 (2) ◽  
pp. 225 ◽  
Author(s):  
Hye Won Chung ◽  
Myung Jin Chung ◽  
Jae Hyung Park ◽  
Jin Wook Chung ◽  
Dong Hyuk Lee ◽  
...  
Keyword(s):  
Pulsatile Flow ◽  
Flow Model ◽  
Doppler Waveform

Attenuation of Flow Disturbances in Tapered Arterial Grafts

1989 ◽  
Vol 111 (4) ◽  
pp. 303-310 ◽  
Author(s):  
R. A. Black ◽  
T. V. How
Keyword(s):  
Pulsatile Flow ◽  
Reynolds Numbers ◽  
Axial Distance ◽  
Pulsed Ultrasound ◽  
Arterial Grafts ◽  
Vascular Prostheses ◽  
Disturbance Intensity ◽  
Flow Disturbances ◽  
Percent Area

Flow disturbances in tapered arterial grafts of angles of taper between 0.5 and 1.0 deg were measured in vitro using a pulsed ultrasound Doppler velocimeter. The increase in transition Reynolds numbers with angle of taper and axial distance was determined for steady flow. The instantaneous centerline velocities were measured distal to a 50 percent area stenosis (as a model of a proximal anastomosis), in steady and pulsatile flow, from which the disturbance intensities were calculated. A significant reduction in post-stenotic disturbance intensity was recorded in the tapered grafts, relative to a conventional cylindrical graft. In pulsatile flow with a large backflow component, however, there was an increase in disturbance intensity due to diverging flow during flow reversal. This was observed only in the 1.0 deg tapered graft. These findings indicate that taper is an important consideration in the design of vascular prostheses.

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