Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.

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Analysis of the etiologies of female infertility in Yunnan minority areas

BMC Women s Health ◽

10.1186/s12905-021-01216-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Fen Zhang ◽

Qing Feng ◽

Linna Yang ◽

Xuelian Liu ◽

Lingyun Su ◽

...

Keyword(s):

Retrospective Study ◽

Comparative Analysis ◽

Pelvic Inflammatory Disease ◽

Inflammatory Disease ◽

Yunnan Province ◽

Female Infertility ◽

Individualized Treatment ◽

Local Hospital ◽

Intrauterine Adhesions ◽

Epidemiological Characteristics

Abstract Background The present study aims to provide a comparative analysis of the etiologies of female infertility between Dehong, on the Yunnan Frontier, and Kunming. Methods A retrospective study, which included 941 infertile females in Kunming who were treated in the First People’s Hospital of Yunnan Province and infertile females who were treated in the local hospital in Dehong from January 2016 to November 2018, was conducted. A comparative analysis of the etiologies of infertility in the two regions was then carried out. Results In patients with primary infertility, ovulation disorder (15.03%) was the main cause of infertility in Kunming, and pelvic inflammatory disease (25.59%) was the main cause in Dehong. With regard to secondary infertility, although pelvic inflammatory disease was the main cause of infertility in both regions, the incidence of intrauterine adhesions in Kunming was significantly higher than in Dehong. Conclusions The etiology of infertility showed different epidemiological characteristics depending on the region, hence individualized treatment should be given accordingly

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The glucagon-like peptide-1 (GLP-1) analog exenatide ameliorates intrauterine adhesions in mice

Peptides ◽

10.1016/j.peptides.2020.170481 ◽

2021 ◽

Vol 137 ◽

pp. 170481

Author(s):

Xiao-ling Ma ◽

Yuan Ding ◽

Lu-Ming Wu ◽

Yi-Xiang Wang ◽

Ying Yao ◽

...

Keyword(s):

Intrauterine Adhesions ◽

Glucagon Like Peptide ◽

Glucagon Like Peptide 1

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LDH, CRP and ALB predict nucleic acid turn negative within 14 days in symptomatic patients with COVID-19

Scottish Medical Journal ◽

10.1177/0036933021994243 ◽

2021 ◽

pp. 003693302199424

Author(s):

Gaoli Liu ◽

Bicheng Zhang ◽

Shaowen Zhang ◽

Haifeng Hu ◽

TingTing Liu

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Nucleic Acid ◽

Hospital Stay ◽

Prognostic Marker ◽

Roc Curve ◽

Prognostic Value ◽

Statistical Significance ◽

Biochemical Indicators ◽

The Relationship

Aims To search for biochemical indicators that can identify symptomatic patients with COVID-19 whose nucleic acid could turn negative within 14 days, and assess the prognostic value of these biochemical indicators in patients with COVID-19. Patients and methods We collected the clinical data of patients with COVID-19 admitted to our hospital, by using logistic regression analysis and AUC curves, explored the relationship between biochemical indicators and nucleic acid positive duration, the severity of COVID-19, and hospital stay respectively. Results A total of two hundred and thirty-three patients with COVID-19 were enrolled in the study. We found patients whose nucleic acid turned negative within 14 days had lower LDH, CRP and higher ALB ( P < 0.05). ROC curve results indicated that lower LDH, TP, CRP and higher ALB predicted the nucleic acid of patients turned negative within 14 days with statistical significance( P < 0.05), AST, LDH, CRP and PCT predicted the severe COVID-19 with statistical significance, and CRP predicted hospital stay >31days with statistical significance ( P < 0.05). After verification, the probability of nucleic acid turning negative within 14 days in patients with low LDH (<256 U/L), CRP (<44.5 mg/L) and high ALB (>35.8 g/L) was about 4 times higher than that in patients with high LDH, CRP and low ALB ( P < 0.05). Conclusions LDH, CRP and ALB are useful prognostic marker for predicting nucleic acid turn negative within 14 days in symptomatic patients with COVID-19.

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