Intérêt d’un dépistage systématique du phéochromocytome chez les patients porteurs d’une neurofibromatose de type 1

2016 ◽  
Vol 40 (3) ◽  
pp. 180-181
Author(s):  
A.-L. Giraudet ◽  
L. Képénékian ◽  
J.-C. Lifante ◽  
C. Houzard ◽  
T. Mognetti ◽  
...  
2015 ◽  
Vol 142 (12) ◽  
pp. S427
Author(s):  
P. Combemale ◽  
L. Képénékian ◽  
J.-C. Lifante ◽  
C. Houzard ◽  
S. Pinson ◽  
...  

2015 ◽  
Vol 76 (4) ◽  
pp. 320
Author(s):  
L. Képénékian ◽  
J.C. Lifante ◽  
T. Mognetti ◽  
S. Pinson ◽  
F. Borson-Chazot ◽  
...  

2013 ◽  
Vol 28 (S2) ◽  
pp. 10-10
Author(s):  
A. Dervaux ◽  
M.O. Krebs ◽  
M.C. Bourdel ◽  
X. Laqueille

ContexteEn dehors de l’étude épidémiologique en population générale NESARC, peu d’études cliniques ont exploré les différences entre hommes et femmes présentant un abus ou une dépendance au cannabis. L’objectif de cette étude était d’évaluer les différences sociodémographiques et cliniques entre les sexes dans une population de 173 patients dépendants au cannabis, demandeurs de soins, sans troubles psychotiques ou bipolaires, ni dépendance à une autre drogue.MéthodesTous les patients de sexe masculin (n = 130) et féminin (n = 43), consultant consécutivement dans le service d’addictologie du centre hospitalier Sainte-Anne (Paris) pour dépendance au cannabis (critères DSM-IV), entre juin 2007 et juin 2013, ont été inclus dans l’étude. Les patients présentant des troubles psychotiques, bipolaires de type 1, des dépendances opiacées ou à la cocaïne étaient exclus de l’étude. Les patients ont été évalués à l’aide du Diagnostic Interview for Genetic Studies (DIGS).RésultatsLa fréquence, présente ou passée, de troubles dépressifs (61,8 % vs 23,1 %, p = 0,0001), de phobies sociales (29,0 % vs 12,4 %, p = 0,02), de troubles anxieux généralisés (43,8 % vs 24,3 %, p = 0,03), de conduites suicidaires (36,6 % vs 11,3 %, p = 0,0001), de traitements anxiolytiques antérieurs (71,4 % vs 44,4 %, p = 0,001), de traitements antidépresseurs antérieurs (63,4 % vs 29,4 %, p = 0,001) et d’antécédents familiaux de dépression (70,3 % vs 39,5 %, p = 0,001), était plus élevée dans le groupe de sujets de sexe féminin que dans le groupe de sujets de sexe masculin. En revanche, la fréquence des effets subjectifs de désinhibition (37,7 % vs 19,0 %, p = 0,03) et d’hypersensorialité (36,9 % vs 19,0 %, p = 0,03), induits par le cannabis, était plus élevée dans le groupe de sujets de sexe masculin. ConclusionsLa fréquence des antécédents de troubles dépressifs et de troubles anxieux, traités ou non, chez les patients dépendants au cannabis, en particulier du sexe féminin, justifie leur dépistage systématique et leur prise en charge intégrée dans la prise en charge addictologique.


Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.


Author(s):  
G.J.C. Carpenter

In zirconium-hydrogen alloys, rapid cooling from an elevated temperature causes precipitation of the face-centred tetragonal (fct) phase, γZrH, in the form of needles, parallel to the close-packed <1120>zr directions (1). With low hydrogen concentrations, the hydride solvus is sufficiently low that zirconium atom diffusion cannot occur. For example, with 6 μg/g hydrogen, the solvus temperature is approximately 370 K (2), at which only the hydrogen diffuses readily. Shears are therefore necessary to produce the crystallographic transformation from hexagonal close-packed (hep) zirconium to fct hydride.The simplest mechanism for the transformation is the passage of Shockley partial dislocations having Burgers vectors (b) of the type 1/3<0110> on every second (0001)Zr plane. If the partial dislocations are in the form of loops with the same b, the crosssection of a hydride precipitate will be as shown in fig.1. A consequence of this type of transformation is that a cumulative shear, S, is produced that leads to a strain field in the surrounding zirconium matrix, as illustrated in fig.2a.


Author(s):  
J. C. Barry ◽  
H. Alexander

Dislocations in silicon produced by plastic deformation are generally dissociated into partials. 60° dislocations (Burgers vector type 1/2[101]) are dissociated into 30°(Burgers vector type 1/6[211]) and 90°(Burgers vector type 1/6[112]) dislocations. The 30° partials may be either of “glide” or “shuffle” type. Lattice images of the 30° dislocation have been obtained with a JEM 100B, and with a JEM 200Cx. In the aforementioned experiments a reasonable but imperfect match was obtained with calculated images for the “glide” model. In the present experiment direct structure images of 30° dislocation cores have been obtained with a JEOL 4000EX. It is possible to deduce the 30° dislocation core structure by direct inspection of the images. Dislocations were produced by compression of single crystal Si (sample preparation technique described in Alexander et al.).


Author(s):  
E. Horvath ◽  
K. Kovacs ◽  
L. Stefaneanu ◽  
N. Losinski

Human pituitary corticotropins have unique morphologic markers: bundles of type-1 filaments, measuring approximately 70 A in width and representing cytokeratin. The extreme ring-like accumulation of type-1 filaments, known as Crooke's hyalinization, signals functional suppression of the corticotropins and occurs in endogenous and exogenous glucocorticoid excess, caused by ACTH-secreting pituitary adenoma, glucocorticoid secreting adrenocortical tumor, ectopic ACTH-syndrome and administration of pharmacologic doses of glucocorticoids. Cells of autonomous corticotroph adenomas usually do not show Crooke's hyalin change. A minority of these tumors, however, retains sensitivity to the negative feed-back effect of elevated blood glucocorticoid levels and display typical Crooke’s change.In the present study pituitary corticotropins in various phases of Crooke's hyalinization were investigated in patients with glucocorticoid excess of various origin, applying histology, immunocytochemistry, count of argyrophilic nucleolar organizer regions (AgNOR), and transmission electron microscopy.


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