scholarly journals Introduction and rapid dissemination of SARS-CoV-2 Gamma Variant of Concern in Venezuela

2021 ◽  
pp. 105147
Author(s):  
Rossana C. Jaspe ◽  
Carmen L. Loureiro ◽  
Yoneira Sulbaran ◽  
Zoila C. Moros ◽  
Pierina D'Angelo ◽  
...  
Keyword(s):  
Rapid Dissemination

scholarly journals Uptake of biosimilar trastuzumab in Denmark compared with other European countries: a comparative study and discussion of factors influencing implementation and uptake of biosimilars

2021 ◽  
Author(s):  
Samuel Azuz ◽  
Max Newton ◽  
Dorthe Bartels ◽  
Birgitte Klindt Poulsen
Keyword(s):  
Comparative Study ◽  
Market Share ◽  
European Countries ◽  
Sales Volume ◽  
Eu Countries ◽  
Factors Influencing ◽  
European Data ◽  
Similar Strategy ◽  
Rapid Dissemination

Abstract Purpose The aim of this study was to describe the implementation and uptake of biosimilar trastuzumab in Denmark compared with other European countries. Methods European data for usage of trastuzumab was supplied by IQVIA™, using the MIDAS® dataset. A comparison was performed based on market share estimated in sales volume. A separate comparison was undertaken between countries with a full two-fold switch between different biosimilars. Data was collected spanning the time from first registered sales of biosimilar trastuzumab until the 1st quarter of 2020. Results Denmark had the fastest and most thorough uptake of biosimilar trastuzumab compared with other EU countries. After 3 months, the market share of biosimilar trastuzumab had increased to 90% while the second fastest country had a 50% market share after 3 months. Only two other countries had undergone a full second switch between biosimilars, Hungary and Norway. All of the three countries made near complete switches between biosimilars while only Denmark had reduced the use of biooriginator below 10%. Conclusion The implementation of biosimilar trastuzumab in Denmark was rapid and achieved high overall uptake compared with other EU countries. The switch from one biosimilar to another was also achieved quickly and thoroughly. We believe that the rapid dissemination of information and involvement of all stakeholders — administrators, pharmacies, prescribers, nurses, and patients — constitute the backbone of the Danish success. A similar strategy is recommend for biosimilar implementation in other countries.

scholarly journals Conservation: A New Open Access Journal for Rapid Dissemination of the Transdisciplinary Dimensions of Biodiversity Conservation

Conservation ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 17-20
Author(s):  
Antoni Margalida ◽  
Luca Luiselli ◽  
José L. Tella ◽  
Shuqing Zhao
Keyword(s):  
Open Access ◽  
Biodiversity Conservation ◽  
Case Reports ◽  
Digital Publishing ◽  
Open Access Journal ◽  
Research Articles ◽  
Original Research ◽  
Rapid Dissemination

We are pleased to launch the new peer-reviewed open access journal, Conservation, published by MDPI (Multidisciplinary Digital Publishing Institute), which offers an exciting new opportunity to publish comprehensive reviews, original research articles, communications, case reports, letters, commentaries, and other perspectives related to the biological, sociological, ethical, economic, methodological, and other transdisciplinary dimensions of conservation [...]

Commission 6: Astronomical Telegrams: (Telegrammes Astronomiques)

2000 ◽  
Vol 24 (1) ◽  
pp. 378-379
Author(s):  
R. M. West ◽  
B. G. Marsden ◽  
K. Aksnes ◽  
S. Nakano ◽  
E. Roemer ◽  
...  
Keyword(s):  
Central Bureau ◽  
Rapid Dissemination

Throughout the triennium, Commission 6 has interacted with the Central Bureau for Astronomical Telegrams (CBAT), most ably headed by Brian Marsden. As will be seen from his report below, the use by scientists of the Circulars for rapid dissemination of astronomical and related news continues unabated.

scholarly journals Mobile Genetic Elements Related to the Diffusion of Plasmid-Mediated AmpC β-Lactamases or Carbapenemases from Enterobacteriaceae: Findings from a Multicenter Study in Spain

2015 ◽  
Vol 59 (9) ◽  
pp. 5260-5266 ◽  
Author(s):  
L. Zamorano ◽  
E. Miró ◽  
C. Juan ◽  
L. Gómez ◽  
G. Bou ◽  
...  
Keyword(s):  
Southern Hybridization ◽  
Mobile Genetic Elements ◽  
Pulsed Field Gel Electrophoresis ◽  
Content Type ◽  
Genetic Elements ◽  
Chromosomal Origin ◽  
Class 1 ◽  
Rapid Dissemination ◽  
Large Plasmids ◽  
Genetic Context

ABSTRACTWe examined the genetic context of 74 acquiredampCgenes and 17 carbapenemase genes from 85 of 640Enterobacteriaceaeisolates collected in 2009. Using S1 pulsed-field gel electrophoresis and Southern hybridization, 37 of 74blaAmpCgenes were located on large plasmids of different sizes belonging to six incompatibility groups. We used sequencing and PCR mapping to investigate the regions flanking the acquiredampCgenes. TheblaCMY-2-like genes were associated with ISEcp1; the surroundingblaDHAgenes were similar toKlebsiella pneumoniaeplasmid pTN60013 associated with IS26and thepspandsapoperons; and theblaACC-1genes were associated with IS26elements inserted into ISEcp1. All of the carbapenemase genes (blaVIM-1,blaIMP-22, andblaIMP-28) were located in class 1 integrons. Therefore, although plasmids are the main cause of the rapid dissemination ofampCgenes amongEnterobacteriaceae, we need to be aware that other mobile genetic elements, such as insertion sequences, transposons, or integrons, can be involved in the mobilization of these genes of chromosomal origin. Additionally, three new integrons (In846 to In848) are described in this study.

scholarly journals Editorial: Rapid Communications

2000 ◽  
Vol 64 (5) ◽  
pp. 545-545
Author(s):  
Alan Cairns ◽  
George Miley
Keyword(s):  
Plasma Physics ◽  
Valuable Addition ◽  
Physics Community ◽  
Rapid Dissemination

It is proposed to add a Rapid Communications section to the Journal of Plasma Physics. Papers submitted to this section should be restricted to no more than five printed pages in length, and should contain new and important ideas that warrant rapid dissemination amongst the plasma physics community. Submissions may be sent to any of the Editors or Associate Editors, who will obtain an assessment of the suitability of the paper as quickly as possible. We hope that readers and authors will find this a valuable addition to the journal.

scholarly journals Exploring Author Profiling for Fake News Detection

2021 ◽  
Author(s):  
Shloak Rathod
Keyword(s):  
False Positive Rate ◽  
True Positive Rate ◽  
Supervised Machine Learning ◽  
Online Media ◽  
Fake News ◽  
Writing Style ◽  
Short Term ◽  
Positive Rate ◽  
Rapid Dissemination ◽  
Author Profiling

<div><div><div><p>The proliferation of online media allows for the rapid dissemination of unmoderated news, unfortunately including fake news. The extensive spread of fake news poses a potent threat to both individuals and society. This paper focuses on designing author profiles to detect authors who are primarily engaged in publishing fake news articles. We build on the hypothesis that authors who write fake news repeatedly write only fake news articles, at least in short-term periods. Fake news authors have a distinct writing style compared to real news authors, who naturally want to maintain trustworthiness. We explore the potential to detect fake news authors by designing authors’ profiles based on writing style, sentiment, and co-authorship patterns. We evaluate our approach using a publicly available dataset with over 5000 authors and 20000 articles. For our evaluation, we build and compare different classes of supervised machine learning models. We find that the K-NN model performed the best, and it could detect authors who are prone to writing fake news with an 83% true positive rate with only a 5% false positive rate.</p></div></div></div>

Did evangelicalism predate the eighteenth century?

2005 ◽  
Vol 77 (2) ◽  
pp. 135-153
Author(s):  
Kenneth J. Stewart
Keyword(s):  
Eighteenth Century ◽  
Extended Period ◽  
Modern Britain ◽  
Rapid Dissemination ◽  
Early Eighteenth Century

Dr. David Bebbington’s remarkable volume, Evangelicalism in Modern Britain: A History from the 1730s to the 1980s, was recognized from its 1989 publication as a work of massive research and winsome presentation. On both sides of the Atlantic, it has justly established its author as a primary interpreter of the Evangelical past. But the volume, in the process of chronicling Evangelical developments across 250 years, has circulated ideas which give pause. Chief among these is the viewpoint, repeatedly urged, that Evangelicalism only began to exist after the pivotal events of the 1730s which we recognize to have marked the onset of an extended period of awakening. While the book certainly allowed that there were movements and individuals inside and outside Britain which served as precursors to Evangelicalism’s emergence, it denies that Evangelicalism itself has a pedigree older than the early eighteenth century. The author of the article has observed the rapid dissemination of this thesis since 1989 and some of the uses to which it is being put. He cautions that we should not concede – as something incontestable – that Evangelicalism had no existence before 1730. If we concede this without more compelling reasons than are put forward in Evangelicalism in Modern Britain we will have prematurely consented to the view that Evangelicalism is merely the child of one era or epoch.

scholarly journals Pandemic publishing: Medical journals strongly speed up their publication process for COVID-19

2020 ◽  
Vol 1 (3) ◽  
pp. 1056-1067 ◽  
Author(s):  
Serge P. J. M. Horbach
Keyword(s):  
Peer Review ◽  
Information Dissemination ◽  
Peer Review Process ◽  
Scholarly Journals ◽  
Medical Journals ◽  
Publication Process ◽  
New Information ◽  
Speed Up ◽  
Rapid Dissemination ◽  
Time Required

In times of public crises, including the current COVID-19 pandemic, rapid dissemination of relevant scientific knowledge is of paramount importance. The duration of scholarly journals’ publication process is one of the main factors that may hinder quick delivery of new information. Following initiatives of medical journals to accelerate their publication process, this study assesses whether medical journals have managed to speed up their publication process for coronavirus-related articles. It studies the duration of 14 medical journals’ publication processes both during and prior to the current pandemic. Assessing 669 articles, the study concludes that medical journals have indeed strongly accelerated their publication process for coronavirus-related articles since the outbreak of the pandemic: The time between submission and publication has decreased on average by 49%. The largest decrease in number of days between submission and publication of articles was due to a decrease in time required for peer review. For articles not related to COVID-19, no acceleration of the publication process is found. While the acceleration of the publication process is laudable from the perspective of quick information dissemination, it also may raise concerns relating to the quality of the peer review process and of the resulting publications.

scholarly journals Cooperative nature of viral replication

2020 ◽  
Vol 6 (49) ◽  
pp. eabd4942
Author(s):  
Iván Andreu-Moreno ◽  
Juan-Vicente Bou ◽  
Rafael Sanjuán
Keyword(s):  
Viral Replication ◽  
Viral Fitness ◽  
Progeny Production ◽  
Short Term ◽  
Viral Particles ◽  
Viral Progeny ◽  
Cooperative Process ◽  
Complex Models ◽  
Rapid Dissemination ◽  
Human Viruses

The ability of viruses to infect their hosts depends on rapid dissemination following transmission. The notion that viral particles function as independent propagules has been challenged by recent observations suggesting that viral aggregates show enhanced infectivity and faster spread. However, these observations remain poorly understood. Here, we show that viral replication is a cooperative process, such that entry of multiple viral genome copies into the same cell disproportionately increases short-term viral progeny production. This cooperativity arises from the positive feedback established between replication templates and virus-encoded products involved in replication and should be a general feature of viruses. We develop a simple model that captures this effect, verify that cooperativity also emerges in more complex models for specific human viruses, validate our predictions experimentally using different mammalian viruses, and discuss the implications of cooperative replication for viral fitness.

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