Vitiligo and Hashimoto’s thyroiditis: Autoimmune diseases linked by clinical presentation, biochemical commonality, and autoimmune/oxidative stress-mediated toxicity pathogenesis

2019 ◽  
Vol 128 ◽  
pp. 69-75 ◽  
Author(s):  
Dongmei Li ◽  
Guanzhao Liang ◽  
Richard Calderone ◽  
Joseph A. Bellanti
Keyword(s):  
Oxidative Stress ◽  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Clinical Presentation ◽  
Hashimoto's Thyroiditis

Immune Thrombocytopenia in an Adolescent with Hashimoto’s Thyroiditis – Case Report

2019 ◽  
Vol 4 (3) ◽  
pp. 145-149 ◽  
Author(s):  
Izabella Kelemen ◽  
Zsuzsanna Erzsébet Papp ◽  
Mária Adrienne Horváth
Keyword(s):  
Platelet Count ◽  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Clinical Signs ◽  
Immunoglobulin Therapy ◽  
Peripheral Blood Smear ◽  
Bleeding Complications ◽  
Hashimoto's Thyroiditis ◽  
Line Treatment ◽  
First Line

Abstract Introduction: In childhood, thrombocytopenia caused by transient antibody-mediated thrombocyte destruction is most frequently diagnosed as immune thrombocytopenic purpura (ITP). We report the case of a girl with ITP associated with autoimmune thyroiditis. Case presentation: A 11-year-old female patient with Hashimoto’s thyroiditis presented with clinical signs of petechiae and ecchymoses on the extremities. Laboratory tests showed remarkable thrombocytopenia with a platelet count of 44,500/μL, hence she was referred to a hematologic consultation. The peripheral blood smear showed normal size platelets in very low range. The bone marrow examination exposed hyperplasia of the megakaryocyte series with outwardly morphologic abnormalities. The patient was diagnosed with ITP, and her first-line treatment was pulsed steroid and immunoglobulin therapy. The thrombocytopenia was refractory to these first-line medications. After 6 months of corticotherapy and a period of severe menorrhagia, azathioprine immunosupression was initiated as a second-line treatment. Her platelet count rapidly increased, and the evolution was good, without bleeding complications. Conclusion: In case of a medical history of autoimmune diseases and treatment-resistant ITP, attention must be focused on detecting coexisting autoimmune diseases and adjusting the treatment in accordance with the chronic evolution of the disease.

Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis

Thyroid ◽  
2016 ◽  
Vol 26 (4) ◽  
pp. 504-511 ◽  
Author(s):  
Rosaria M. Ruggeri ◽  
Teresa M. Vicchio ◽  
Mariateresa Cristani ◽  
Rosaria Certo ◽  
Daniela Caccamo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Advanced Glycation End Products ◽  
Hashimoto’S Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals High Prevalence of Infertility among Women with Graves’ Disease and Hashimoto’s Thyroiditis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Alessandra Quintino-Moro ◽  
Denise E. Zantut-Wittmann ◽  
Marcos Tambascia ◽  
Helymar da Costa Machado ◽  
Arlete Fernandes
Keyword(s):  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Graves Disease ◽  
Cross Sectional ◽  
Unprotected Sexual Intercourse ◽  
High Prevalence ◽  
History Of ◽  
Endocrinology Clinic

Objectives. To evaluate the prevalence of infertility in women with Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) and associated factors.Material and Methods. This cross-sectional study was conducted at the Endocrinology Clinic for Thyroid Autoimmune Diseases, with 193 women aged 18–50 years with GD and 66 women aged 18–60 years with HT. The women were interviewed to obtain data on their gynecological and obstetric history and family history of autoimmune diseases. Their medical records were reviewed to determine the characteristics of the disease and to confirm association with other autoimmune diseases. Infertility was defined as 12 months of unprotected sexual intercourse without conception.Results. The prevalence of infertility was 52.3% in GD and 47.0% in HT. Mean age at diagnosis was 36.5 years and 39.2 years, in GD and HT, respectively. The mean number of pregnancies was lower in women who were 35 years old or younger at diagnosis and was always lower following diagnosis of the disease, irrespective of age. The only variable associated with infertility was a shorter time of the disease in HT.Conclusions. The prevalence of infertility was high in women with GD and HT and affected the number of pregnancies in young women.

scholarly journals Autoimmune comorbidities in Hashimoto’s thyroiditis: different patterns of association in adulthood and childhood/adolescence

2017 ◽  
Vol 176 (2) ◽  
pp. 133-141 ◽  
Author(s):  
R M Ruggeri ◽  
F Trimarchi ◽  
G Giuffrida ◽  
R Certo ◽  
E Cama ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Hashimoto’S Thyroiditis ◽  
Skin Diseases ◽  
Connective Tissue Diseases ◽  
Cross Sectional Study ◽  
Hashimoto's Thyroiditis ◽  
Cross Sectional ◽  
Autoimmune Thyroid ◽  
Adult Age

Objective Hashimoto’s thyroiditis (HT), the most common autoimmune thyroid disease at any age, is often associated with other autoimmune diseases. The present study was aimed to describe the type and frequency of non-thyroidal autoimmune diseases (NTADs) in HT patients and to delineate the clinical pattern of diseases clustering in pediatric/adolescent and adult age. Design Cross-sectional study. Methods 1053 newly diagnosed HT patients (500 adults (467 F, mean age 40.2 ± 13.7 years) and 553 children/adolescents (449 F, mean age 11.1 ± 3.0 years)) were evaluated for common NTADs by means of careful recording of medical history, physical examination and assessment of selected autoantibody profiles. Results The prevalence of associated NTADs was significantly higher in adults than that in pediatric/adolescent HT patients (P < .0001). In addition, the number of adult patients suffering from two or more associated NTADs was significantly higher than that of children/adolescent (P < 0.0001). A female prevalence was evident in both cohorts, but was significant in the adults (P < 0.0001). The epidemiological distribution of NTADs was strongly different in the two cohorts, the most frequent associated diseases being arthropathies and connective tissue diseases in adults and type 1 diabetes and coeliac disease in children/adolescents. Skin diseases were represented with similar prevalence in both cohorts, vitiligo being the most common. Conclusions Age at HT presentation may influence autoimmune diseases clustering, favoring the association of specific NTADs in different ages of life. Moreover, the association between HT and NTADs increases with age and occurs most frequently in adults.

scholarly journals Does treatment with levothyroxine sodium decrease oxidative stress in Hashimoto's thyroiditis?

2015 ◽  
Author(s):  
Ihsan Ates ◽  
Mustafa Altay ◽  
Fatma Meric Yilmaz ◽  
Nisbet Yilmaz ◽  
Serdar Guler
Keyword(s):  
Oxidative Stress ◽  
Hashimoto’S Thyroiditis ◽  
Levothyroxine Sodium ◽  
Hashimoto's Thyroiditis

Megalo-Goitrous Form of Hashimoto's Thyroiditis: A Rare Indication for Surgery

2012 ◽  
Vol 4 (1) ◽  
pp. 15-16
Author(s):  
Bhargav PRK ◽  
V Amar ◽  
SK Uday
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Rare Case ◽  
Clinical Presentation ◽  
Hashimoto's Thyroiditis ◽  
Indication For Surgery ◽  
Thyroxine Treatment ◽  
Large Goiter

ABSTRACT Hashimoto's thyroiditis (HT) is the commonest cause of hypothyroidism, especially in iodine replete areas. The clinical presentation of HT is usually insidious with mild goiter and progressive hypothyroidism. But, HT presents with large goiter and compressive symptoms in some cases. The treatment of HT is mostly conservative with thyroxine treatment sooner or later. Occasionally, surgery is indicated for large goiters with persistent pressure symptoms or associated nodules. We report a rare case of unusually large goiter with compressive symptoms, hitherto unreported in literature. How to cite this article Bhargav PRK, Amar V, Uday SK. Megalo-Goitrous Form of Hashimoto's Thyroiditis: A Rare Indication for Surgery. World J Endocr Surg 2012;4(1):15-16.

scholarly journals Influence of Dietary Habits on Oxidative Stress Markers in Hashimoto's Thyroiditis

Thyroid ◽  
2020 ◽  
Author(s):  
Rosaria Maddalena Ruggeri ◽  
Salvatore Giovinazzo ◽  
Maria Cristina Barbalace ◽  
Mariateresa Cristani ◽  
Angela Alibrandi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hashimoto’S Thyroiditis ◽  
Dietary Habits ◽  
Hashimoto's Thyroiditis ◽  
Oxidative Stress Markers ◽  
Stress Markers
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