The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: A randomized crossover trial

Purpose: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin and triglycerides in adults with medication-controlled type 2 diabetes (T2D). Methods: Participants [n=23, 10 females, Age: 62±8 y (mean±SD), BMI: 32.7 ± 3.5 kg.m-2] completed a three-armed randomized crossover trial (6-14 day washout): sitting uninterrupted for 7 h (SIT); sitting with 3-minute SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (SRA3); and, sitting with 6-minute SRAs every 60 minutes (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions. Results: <a>Glucose and insulin 7 h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol.h.L-1, 95% CI 12.5, 21.4; insulin 1229 pmol.h.L-1, 95% CI 982, 1538) when compared to SIT (glucose 21.4 mmol.h.L-1, 95% CI 16.9, 25.8; insulin 1411 pmol.h.L-1, 95% CI 1128, 1767; P < 0.05), and compared to SRA3 ( for glucose only; 22.1 mmol.h.L-1, 95% CI 17.7, 26.6; P = 0.01) No significant differences in glucose or insulin iAUCnet were observed comparing SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet. </a> Conclusion: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-minute SRAs every 60 minutes reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.

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Frequency of Interruptions to Sitting Time: Benefits for Postprandial Metabolism in Type 2 Diabetes

10.2337/figshare.14096582.v2 ◽

2021 ◽

Author(s):

Ashleigh R. Homer ◽

Frances C. Taylor ◽

Paddy C. Dempsey ◽

Michael J. Wheeler ◽

Parneet Sethi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Clinical Relevance ◽

Crossover Trial ◽

Postprandial Glucose ◽

Sitting Time ◽

Postprandial Metabolism ◽

Prolonged Sitting ◽

Randomized Crossover Trial ◽

Insulin Responses

Purpose: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin and triglycerides in adults with medication-controlled type 2 diabetes (T2D). Methods: Participants [n=23, 10 females, Age: 62±8 y (mean±SD), BMI: 32.7 ± 3.5 kg.m-2] completed a three-armed randomized crossover trial (6-14 day washout): sitting uninterrupted for 7 h (SIT); sitting with 3-minute SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (SRA3); and, sitting with 6-minute SRAs every 60 minutes (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions. Results: <a>Glucose and insulin 7 h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol.h.L-1, 95% CI 12.5, 21.4; insulin 1229 pmol.h.L-1, 95% CI 982, 1538) when compared to SIT (glucose 21.4 mmol.h.L-1, 95% CI 16.9, 25.8; insulin 1411 pmol.h.L-1, 95% CI 1128, 1767; P < 0.05), and compared to SRA3 ( for glucose only; 22.1 mmol.h.L-1, 95% CI 17.7, 26.6; P = 0.01) No significant differences in glucose or insulin iAUCnet were observed comparing SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet. </a> Conclusion: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-minute SRAs every 60 minutes reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.

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Frequency of Interruptions to Sitting Time: Benefits for Postprandial Metabolism in Type 2 Diabetes

10.2337/figshare.14096582 ◽

2021 ◽

Author(s):

Ashleigh R. Homer ◽

Frances C. Taylor ◽

Paddy C. Dempsey ◽

Michael J. Wheeler ◽

Parneet Sethi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Clinical Relevance ◽

Crossover Trial ◽

Postprandial Glucose ◽

Sitting Time ◽

Postprandial Metabolism ◽

Prolonged Sitting ◽

Randomized Crossover Trial ◽

Insulin Responses

Purpose: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin and triglycerides in adults with medication-controlled type 2 diabetes (T2D). Methods: Participants [n=23, 10 females, Age: 62±8 y (mean±SD), BMI: 32.7 ± 3.5 kg.m-2] completed a three-armed randomized crossover trial (6-14 day washout): sitting uninterrupted for 7 h (SIT); sitting with 3-minute SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (SRA3); and, sitting with 6-minute SRAs every 60 minutes (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions. Results: <a>Glucose and insulin 7 h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol.h.L-1, 95% CI 12.5, 21.4; insulin 1229 pmol.h.L-1, 95% CI 982, 1538) when compared to SIT (glucose 21.4 mmol.h.L-1, 95% CI 16.9, 25.8; insulin 1411 pmol.h.L-1, 95% CI 1128, 1767; P < 0.05), and compared to SRA3 ( for glucose only; 22.1 mmol.h.L-1, 95% CI 17.7, 26.6; P = 0.01) No significant differences in glucose or insulin iAUCnet were observed comparing SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet. </a> Conclusion: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-minute SRAs every 60 minutes reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.

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Postprandial Metabolic Effects of Accelerometer Measured Spontaneous Low-Level Activity

Journal of Physical Activity and Health ◽

10.1123/jpah.2014-0298 ◽

2015 ◽

Vol 12 (8) ◽

pp. 1133-1138 ◽

Cited By ~ 1

Author(s):

Meredith C. Peddie ◽

Claire Cameron ◽

Nancy Rehrer ◽

Tracy Perry

Keyword(s):

Heart Rate ◽

Glucose Metabolism ◽

Sedentary Time ◽

Area Under The Curve ◽

Postprandial Glucose ◽

Metabolic Effects ◽

Negative Effects ◽

Prolonged Sitting ◽

Total Movement ◽

Mean Heart Rate

Background:Interrupting sedentary time induces improvements in glucose metabolism; however, it is unclear how much activity is required to reduce the negative effects of prolonged sitting.Methods:Sixty-six participants sat continuously for 9 hours except for required bathroom breaks. Participants were fed meal replacement beverages at 60, 240 and 420 min. Blood samples were obtained hourly for 9 hours, with additional samples collected 30 and 45 min after each feeding. Responses were calculated as incremental area under the curve (iAUC) for plasma glucose, insulin and triglyceride. Participants wore a triaxial accelerometer and a heart rate monitor. Energy expenditure was estimated using indirect calorimetry.Results:After controlling for age, sex and BMI, every 100 count increase in accelerometer derived total movement was associated with a 0.06 mmol·L-1·9 hours decrease in glucose iAUC (95% CI 0.004–0.1; P = .035), but not associated with changes in insulin or triglyceride iAUC. Every 1 bpm increase in mean heart rate was associated with a 0.76 mmol·L-1·9 hours increase in triglyceride iAUC (95% CI 0.13–1.38).Conclusion:Accelerometer measured movement during periods of prolonged sitting can result in minor improvements in postprandial glucose metabolism, but not lipid metabolism.

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Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals

Frontiers in Endocrinology ◽

10.3389/fendo.2020.566548 ◽

2020 ◽

Vol 11 ◽

Author(s):

Steven Carter ◽

Thomas P. J. Solomon

Keyword(s):

Crossover Trial ◽

Postprandial Glucose ◽

Healthy Individuals ◽

Glucose Response ◽

Randomized Crossover Trial ◽

Exercise Induced

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Effect of meal composition and alcohol consumption on postprandial glucose concentration in subjects with type 1 diabetes: a randomized crossover trial

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2021-002399 ◽

2021 ◽

Vol 9 (1) ◽

pp. e002399

Author(s):

Alia García ◽

Vanessa Moscardó ◽

Agustín Ramos-Prol ◽

Julián Díaz ◽

Miguel Boronat ◽

...

Keyword(s):

Fatty Acids ◽

Type 1 Diabetes ◽

Crossover Trial ◽

Postprandial Glucose ◽

High Fat ◽

Mixed Meal ◽

Low Protein ◽

Randomized Crossover Trial ◽

Meal Composition

IntroductionMeal composition is known to affect glycemic variability and glucose control in type 1 diabetes. The objective of this work was to evaluate the effect of high carbohydrate meals of different nutritional composition and alcohol on the postprandial glucose response in patients with type 1 diabetes.Research design and methodsTwelve participants were recruited to this randomized crossover trial. Following a 4-week run-in period, participants received a mixed meal on three occasions with the same carbohydrate content but different macronutrient composition: high protein-high fat with alcohol (0.7g/kg body weight, beer), high protein-high fat without alcohol, and low protein-low fat without alcohol at 2-week intervals. Plasma and interstitial glucose, insulin, glucagon, growth hormone, cortisol, alcohol, free fatty acids, lactate, and pH concentrations were measured during 6 hours. A statistical analysis was then carried out to determine significant differences between studies.ResultsSignificantly higher late postprandial glucose was observed in studies with higher content of fats and proteins (p=0.0088). This was associated with lower time in hypoglycemia as compared with the low protein and fat study (p=0.0179), at least partially due to greater glucagon concentration in the same period (p=0.04). Alcohol significantly increased lactate, decreased pH and growth hormone, and maintained free fatty acids suppressed during the late postprandial phase (p<0.001), without significant changes in plasma glucose.ConclusionsOur data suggest that the addition of proteins and fats to carbohydrates increases late postprandial blood glucose. Moreover, alcohol consumption together with a mixed meal has relevant metabolic effects without any increase in the risk of hypoglycemia, at least 6 hours postprandially.Trial registration numberNCT03320993.

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