Frequency of Interruptions to Sitting Time: Benefits for Postprandial Metabolism in Type 2 Diabetes

Purpose: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin and triglycerides in adults with medication-controlled type 2 diabetes (T2D). Methods: Participants [n=23, 10 females, Age: 62±8 y (mean±SD), BMI: 32.7 ± 3.5 kg.m-2] completed a three-armed randomized crossover trial (6-14 day washout): sitting uninterrupted for 7 h (SIT); sitting with 3-minute SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (SRA3); and, sitting with 6-minute SRAs every 60 minutes (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions. Results: <a>Glucose and insulin 7 h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol.h.L-1, 95% CI 12.5, 21.4; insulin 1229 pmol.h.L-1, 95% CI 982, 1538) when compared to SIT (glucose 21.4 mmol.h.L-1, 95% CI 16.9, 25.8; insulin 1411 pmol.h.L-1, 95% CI 1128, 1767; P < 0.05), and compared to SRA3 ( for glucose only; 22.1 mmol.h.L-1, 95% CI 17.7, 26.6; P = 0.01) No significant differences in glucose or insulin iAUCnet were observed comparing SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet. </a> Conclusion: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-minute SRAs every 60 minutes reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.

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Frequency of Interruptions to Sitting Time: Benefits for Postprandial Metabolism in Type 2 Diabetes

10.2337/figshare.14096582 ◽

2021 ◽

Author(s):

Ashleigh R. Homer ◽

Frances C. Taylor ◽

Paddy C. Dempsey ◽

Michael J. Wheeler ◽

Parneet Sethi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Clinical Relevance ◽

Crossover Trial ◽

Postprandial Glucose ◽

Sitting Time ◽

Postprandial Metabolism ◽

Prolonged Sitting ◽

Randomized Crossover Trial ◽

Insulin Responses

Purpose: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin and triglycerides in adults with medication-controlled type 2 diabetes (T2D). Methods: Participants [n=23, 10 females, Age: 62±8 y (mean±SD), BMI: 32.7 ± 3.5 kg.m-2] completed a three-armed randomized crossover trial (6-14 day washout): sitting uninterrupted for 7 h (SIT); sitting with 3-minute SRAs (half-squats, calf raises, gluteal contractions, and knee raises) every 30 minutes (SRA3); and, sitting with 6-minute SRAs every 60 minutes (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions. Results: <a>Glucose and insulin 7 h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol.h.L-1, 95% CI 12.5, 21.4; insulin 1229 pmol.h.L-1, 95% CI 982, 1538) when compared to SIT (glucose 21.4 mmol.h.L-1, 95% CI 16.9, 25.8; insulin 1411 pmol.h.L-1, 95% CI 1128, 1767; P < 0.05), and compared to SRA3 ( for glucose only; 22.1 mmol.h.L-1, 95% CI 17.7, 26.6; P = 0.01) No significant differences in glucose or insulin iAUCnet were observed comparing SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet. </a> Conclusion: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-minute SRAs every 60 minutes reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.

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Does Interrupting Prolonged Sitting With 10- or 20-Min Standing Attenuate Postprandial Glycemia and Blood Pressure in Middle-Aged and Older Adults With Type 2 Diabetes?

Journal of Aging and Physical Activity ◽

10.1123/japa.2020-0418 ◽

2020 ◽

pp. 1-8

Author(s):

Yuri A. Freire ◽

Carlos A. Silva ◽

Geovani A. D. Macêdo ◽

Rodrigo A. V. Browne ◽

Bruno M. de Oliveira ◽

...

Keyword(s):

Blood Pressure ◽

Type 2 Diabetes ◽

Older Adults ◽

Area Under The Curve ◽

Acute Effect ◽

Sitting Time ◽

Middle Aged ◽

Postprandial Glycemia ◽

Prolonged Sitting

We carried out three types of 2-hr experimental sessions with middle-aged and older adults with Type 2 diabetes in order to examine the acute effect of interrupting prolonged sitting with varying periods of standing on postprandial glycemia and blood pressure (BP): (a) prolonged sitting after breakfast; (b) standing for 10 min, 30 min after breakfast; and (c) standing for 20 min, 30 min after breakfast. Glucose and BP were assessed before and after breakfast. A generalized linear model revealed no significant differences for the incremental area under the curve of glucose between standing for 10 min, 30 min after breakfast, versus prolonged sitting after breakfast (β = –4.5 mg/dl/2 hr, 95% CI [–17.3, 8.4]) and standing for 20 min, 30 min after breakfast, versus prolonged sitting after breakfast (β = 0.9 mg/dl/2 hr, 95% CI [–11.9, 13.7]). There was no difference in area under the curve of systolic and diastolic BP among the sessions. Interrupting prolonged sitting time with 10 or 20 min of standing 30 min after breakfast does not attenuate postprandial glycemia or BP in middle-aged and older adults with Type 2 diabetes.

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The Durability of Basal Insulin Affects Day-to-Day Glycemic Variability Assessed by Continuous Glucose Monitoring in Type 2 Diabetes Patients: A Randomized Crossover Trial

Diabetes Technology & Therapeutics ◽

10.1089/dia.2017.0028 ◽

2017 ◽

Vol 19 (8) ◽

pp. 457-462 ◽

Cited By ~ 8

Author(s):

Hiroyuki Iuchi ◽

Masaya Sakamoto ◽

Daisuke Matsutani ◽

Hirofumi Suzuki ◽

Ryuzo Horiuchi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Continuous Glucose Monitoring ◽

Basal Insulin ◽

Crossover Trial ◽

Glucose Monitoring ◽

Glycemic Variability ◽

Randomized Crossover Trial ◽

Diabetes Patients

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Time‐Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial

Obesity ◽

10.1002/oby.22449 ◽

2019 ◽

Cited By ~ 21

Author(s):

Amy T. Hutchison ◽

Prashant Regmi ◽

Emily N.C. Manoogian ◽

Jason G. Fleischer ◽

Gary A. Wittert ◽

...

Keyword(s):

Type 2 Diabetes ◽

At Risk ◽

Glucose Tolerance ◽

Crossover Trial ◽

Restricted Feeding ◽

Randomized Crossover Trial

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Influence of the Physical Form of Processed Rice Products on the Enzymatic Hydrolysis of Rice Starchin Vitroand on the Postprandial Glucose and Insulin Responses in Patients with Type 2 Diabetes Mellitus

Bioscience Biotechnology and Biochemistry ◽

10.1271/bbb.68.1831 ◽

2004 ◽

Vol 68 (9) ◽

pp. 1831-1836 ◽

Cited By ~ 10

Author(s):

Jae Cherl KIM ◽

Jung-In KIM ◽

Byoung-Wook KONG ◽

Min-Jung KANG ◽

Myo-Jeong KIM ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Enzymatic Hydrolysis ◽

Postprandial Glucose ◽

Physical Form ◽

Insulin Responses ◽

Hydrolysis Of

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Publisher Correction: Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial

Nature Medicine ◽

10.1038/s41591-021-01504-5 ◽

2021 ◽

Author(s):

Charlotte K. Boughton ◽

Afroditi Tripyla ◽

Sara Hartnell ◽

Aideen Daly ◽

David Herzig ◽

...

Keyword(s):

Type 2 Diabetes ◽

Insulin Therapy ◽

Glucose Control ◽

Closed Loop ◽

Crossover Trial ◽

Open Label ◽

Randomized Crossover Trial

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Effect of Sugar-Free and Regular Toothpaste on Salivary Glucose and pH among Type 2 Diabetes- A Randomized Crossover Trial

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2017/25580.10250 ◽

2017 ◽

Author(s):

Junaid Kapadia

Keyword(s):

Type 2 Diabetes ◽

Crossover Trial ◽

Randomized Crossover Trial

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778-P: Positive Effects Including Prevention of Type 2 Diabetes by Making One Meal a Vegetarian Diet in Japanese—A Randomized Crossover Trial

Diabetes ◽

10.2337/db19-778-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 778-P

Author(s):

EITA NISHIMORI ◽

SATOSHI OGATA ◽

MOTOJI NAKA

Keyword(s):

Type 2 Diabetes ◽

Crossover Trial ◽

Vegetarian Diet ◽

Positive Effects ◽

Randomized Crossover Trial

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Resveratrol treatment does not reduce arterial inflammation in males at risk of type 2 diabetes: a randomized crossover trial

Nuklearmedizin ◽

10.1055/a-1585-7215 ◽

2021 ◽

Author(s):

Ellen Boswijk ◽

Marlies de Ligt ◽

Marie-Fleur J Habets ◽

Alma M.A. Mingels ◽

Wouter D. van Marken Lichtenbelt ◽

...

Keyword(s):

Type 2 Diabetes ◽

Adipose Tissue ◽

Crossover Trial ◽

Placebo Treatment ◽

Fdg Uptake ◽

Resveratrol Treatment ◽

Randomized Crossover Trial ◽

Arterial Inflammation ◽

18F Fdg

Abstract Purpose Resveratrol has shown promising anti-inflammatory effects in in vitro and animal studies. We aimed to investigate this effect on arterial inflammation in vivo. Methods This was an additional analysis of a double-blind randomized crossover trial which included eight male subjects with decreased insulin sensitivity who underwent an 18F-fluoroxyglucose (18F-FDG) PET/CT after 34 days of placebo and resveratrol treatment (150 mg/day). 18F-FDG uptake was analyzed in the carotid arteries and the aorta, adipose tissue regions, spleen, and bone marrow as measures for arterial and systemic inflammation. Maximum target-to-background ratios (TBRmax) were compared between resveratrol and placebo treatment with the non-parametric Wilcoxon signed-rank test. Median values are shown with their interquartile range. Results Arterial 18F-FDG uptake was non-significantly higher after resveratrol treatment (TBRmax all vessels 1.7 (1.6–1.7)) in comparison to placebo treatment (1.5 (1.4–1.6); p=0.050). Only in visceral adipose tissue, the increase in 18F-FDG uptake after resveratrol reached statistical significance (p=0.024). Furthermore, CRP-levels were not significantly affected by resveratrol treatment (p=0.091). Conclusions Resveratrol failed to attenuate arterial or systemic inflammation as measured with 18F-FDG PET in subjects at risk of developing type 2 diabetes. However, validation of these findings in larger human studies is needed.

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