A meta-analysis on associations between vitamin D receptor genetic variants and tuberculosis

We performed a meta-analysis to evaluate potential associations between vitamin D receptor ( VDR) genetic variants and tuberculosis (TB). Systematic literature research was conducted in PubMed, Web of Science, and Embase. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations in all possible genetic models, and P values ≤ 0.05 were considered to be statistically significant. In total, 42 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rs1544410 (dominant model: P = 0.02; allele model: P = 0.03) and rs731236 (dominant model: P = 0.04; recessive model: P = 0.02; allele model: P = 0.01) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rs1544410 (dominant and allele models) and rs731236 (dominant, recessive, and allele models) variants were both significantly associated with TB in South Asians. When we stratified data by type of disease, positive results were detected for rs7975232 variant in EPTB (dominant, recessive, over-dominant, and allele models) subgroup, and for rs2228570 variant in PTB (dominant, recessive, and allele models) and EPTB (dominant, recessive, over-dominant, and allele models) subgroups. Our meta-analysis supported that rs7975232, rs1544410, rs2228570, and rs731236 variants might serve as genetic biomarkers of certain types of TB.

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Associations between vitamin D receptor genetic variants and periodontitis: a meta-analysis

Acta Odontologica Scandinavica ◽

10.1080/00016357.2019.1597160 ◽

2019 ◽

Vol 77 (7) ◽

pp. 484-494 ◽

Cited By ~ 5

Author(s):

Xiaohong Yu ◽

Xiaoming Zong ◽

Yan Pan

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Genetic Variants ◽

Meta Analysis

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A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders

Aging Clinical and Experimental Research ◽

10.1007/s40520-019-01135-4 ◽

2019 ◽

Vol 32 (1) ◽

pp. 21-27 ◽

Cited By ~ 3

Author(s):

Jiao Geng ◽

Jianjun Zhang ◽

Fudong Yao ◽

Xiajun Liu ◽

Jijun Liu ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Vitamin D Receptor ◽

Neurodegenerative Disorders ◽

Genetic Variants ◽

Meta Analysis

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Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (MetS): A Meta-Analysis

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320666200805101302 ◽

2020 ◽

Vol 20 ◽

Author(s):

Hamidreza Totonchi ◽

Ramazan Rezaei ◽

Shokoofe Noori ◽

Negar Azarpira ◽

Pooneh Mokarram ◽

...

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Receptor ◽

Protective Factor ◽

Meta Analysis ◽

Receptor Gene ◽

Fixed Effect Model ◽

Fixed Effect ◽

Vdr Gene ◽

Effect Model

Introduction: Several studies have assessed the association between the vitamin D receptor (VDR) polymorphism and risk of metabolic syndrome (MetS). However, the results were inconsistent and inconclusive. Therefore, we conducted a meta-analysis to clarify the exact association between the vitamin D receptor (VDR) polymorphisms and the risk of MetS. Methods: All accessible studies reporting the association between the FokI (rs2228570) or / and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232 polymorphisms of the Vitamin D Receptor and susceptibility to MetS published prior to February 2019 were systematically searched in Web of Science, Scopus, and PubMed. After that, Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated to evaluate the strength of the association in five genetic models. Results: A total of 9 articles based on four gene variations, and comprising 3348 participants with 1779 metabolic syndrome patients were included. The overall results suggested a significant association between BsmI (rs1544410) polymorphism and MetS susceptibility in recessive model (OR, 0.72, 95% CI, 0.55-0.95, fixed effect model), allelic model (OR, 0.83, 95% CI, 0.72-0.95, fixed effect model), and bb vs BB (OR, 0.65, 95% CI, 0.46-0.93, fixed effect). However, no significant association was identified between TaqI (rs731236) polymorphism, ApaI (rs7975232) polymorphism, and FokI (rs2228570) polymorphism and MetS. Conclusion: This meta-analysis suggested an association between the BsmI (rs1544410) polymorphism and MetS. Indeed, BsmI (rs1544410) acts as a protective factor in the MetS. As a result, the VDR gene could be regarded as a promising pharmacological and physiological target in prevention or treatment of the MetS.

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