scholarly journals Listeria adhesion protein-expressing bioengineered probiotics prevent fetoplacental transmission of Listeria monocytogenes in a pregnant Guinea pig model

2021 ◽  
Vol 151 ◽  
pp. 104752
Author(s):  
Valerie E. Ryan ◽  
Taylor W. Bailey ◽  
Dongqi Liu ◽  
Tracy Vemulapalli ◽  
Bruce Cooper ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Guinea Pig ◽  
Pig Model ◽  
Adhesion Protein ◽  
Listeria Adhesion Protein ◽  
Guinea Pig Model

A Processing Plant Persistent Strain of Listeria monocytogenes Crosses the Fetoplacental Barrier in a Pregnant Guinea Pig Model

2008 ◽  
Vol 71 (5) ◽  
pp. 1028-1034 ◽  
Author(s):  
ANNE JENSEN ◽  
DENITA WILLIAMS ◽  
ELIZABETH A. IRVIN ◽  
LONE GRAM ◽  
MARY ALICE SMITH
Keyword(s):  
Listeria Monocytogenes ◽  
Guinea Pig ◽  
Random Amplified Polymorphic Dna ◽  
Foodborne Pathogen ◽  
Pig Model ◽  
Clinical Strain ◽  
Processing Plant ◽  
Virulence Potential ◽  
Processing Plants ◽  
Guinea Pig Model

The foodborne pathogen Listeria monocytogenes can cause infection in immunocompromised humans and in the fetuses of pregnant women. We have demonstrated that one group of genetically similar L. monocytogenes strains (random amplified polymorphic DNA [RAPD] type 9) dominate and persist in several independent fish processing plants. The purpose of the present study was to determine the virulence potential of one RAPD type 9 strain (La111), one human clinical strain (Scott A), and one monkey clinical strain (12443) in a pregnant guinea pig model. Animals were orally exposed to 108 CFU of L. monocytogenes in whipping cream on gestation day (GD) 36 and euthanized on GD 42, 45, or 56. Strains 12443 and Scott A were shed from treated animals for 20 days, whereas La111 was shed only in the first 10 days. Strains 12443 and Scott A were recovered from maternal liver, spleen, and gallbladder on all 3 days of euthanization, whereas La111 was recovered only at GD 45 and 56. Scott A was not isolated from any placentas or fetuses. For dams treated with 12443, 22% of the fetuses were positive for L. monocytogenes, and surprisingly, treatment of dams with La111 resulted in 56% infected fetuses. L. monocytogenes was isolated from 16 and 20% of placentas for 12443 and La111, respectively. The study demonstrates that a food processing plant persistent strain of L. monocytogenes is able to cross the fetoplacental barrier in pregnant guinea pigs. Furthermore, we demonstrate that although information can be gained from model virulence assays, assessment of the virulence potential of a strain may require more complex hosts.

In vivo activity of pyrimidine-dispirotripiperaziniumin in the male guinea pig model of genital herpes

2020 ◽  
Vol 09 (01) ◽  
Author(s):  
Novoselova EA ◽  
Alimbarova LM ◽  
Monakhova NS ◽  
Lepioshkin AY ◽  
Ekins S ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Genital Herpes ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Quantitative cartilage degeneration associated with spontaneous osteoarthritis in a guinea pig model

2011 ◽  
Vol 35 (4) ◽  
pp. 891-898 ◽  
Author(s):  
Matthew C. Fenty ◽  
George R. Dodge ◽  
Victor Babu Kassey ◽  
Walter R.T. Witschey ◽  
Arijitt Borthakur ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Cartilage Degeneration ◽  
Pig Model ◽  
Guinea Pig Model

Suppression of Late Asthmatic Response by Low-Dose Oral Administration of Interferon-beta in the Guinea Pig Model of Asthma

1999 ◽  
Vol 19 (8) ◽  
pp. 887-894 ◽  
Author(s):  
Yu-Ichiro Satoh ◽  
Kyoko Kasama ◽  
Mikiko Kuwabara ◽  
Hong-Yan Diao ◽  
Hirofumi Nakajima ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Oral Administration ◽  
Low Dose ◽  
Interferon Beta ◽  
Pig Model ◽  
Asthmatic Response ◽  
Late Asthmatic Response ◽  
Dose Oral ◽  
Guinea Pig Model

scholarly journals Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 749 ◽  
Author(s):  
Stine Hansen ◽  
Jane Jørgensen ◽  
Jens Nyengaard ◽  
Jens Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Synaptic Plasticity ◽  
Vitamin C ◽  
Guinea Pig ◽  
Early Life ◽  
Pyramidal Neurons ◽  
Pig Model ◽  
Vitamin C Deficiency ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Guinea Pig Model
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