scholarly journals Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells

2017 ◽  
Vol 65 (6) ◽  
pp. 1122-1135.e5 ◽  
Author(s):  
Joshua D. Stender ◽  
Jerome C. Nwachukwu ◽  
Irida Kastrati ◽  
Yohan Kim ◽  
Tobias Strid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Molecular Mechanisms ◽  
Endocrine Resistance ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells

2012 ◽  
Vol 11 (7) ◽  
pp. 1488-1499 ◽  
Author(s):  
C. Elizabeth Caldon ◽  
C. Marcelo Sergio ◽  
Jian Kang ◽  
Anita Muthukaruppan ◽  
Marijke N. Boersma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Endocrine Resistance ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cyclin E2

Unveiling the molecular mechanisms involved in the cytotoxicity induced by photodynamic therapy in human breast cancer cells

2015 ◽  
Vol 12 (3) ◽  
pp. 349
Author(s):  
A.F. dos Santos ◽  
L.F. Terra ◽  
R.A.M. Wailemann ◽  
T.C. Oliveira ◽  
M.S. Baptista ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Molecular Mechanisms ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Distinct photooxidation-induced cell death pathways lead to selective killing of human breast cancer cells

2020 ◽  
Author(s):  
Ancély F. dos Santos ◽  
Alex Inague ◽  
Gabriel S. Arini ◽  
Letícia F. Terra ◽  
Rosangela A.M. Wailemann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Molecular Mechanisms ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cell Death Pathways ◽  
Photooxidative Damage ◽  
Tumorigenic Cells

AbstractLack of effective treatments for aggressive breast cancer is still a major global health problem. We previously reported that Photodynamic Therapy using Methylene Blue as photosensitizer (MB-PDT) massively kills metastatic human breast cancer, marginally affecting healthy cells. In this study we aimed to unveil the molecular mechanisms behind MB-PDT effectiveness. Through lipidomic and biochemical approaches we demonstrated that MB-PDT efficiency and specificity relies on polyunsaturated fatty acids-enriched membranes and on the better capacity to deal with photooxidative damage displayed by non-tumorigenic cells. We found out that, in tumorigenic cells, lysosome membrane permeabilization is accompanied by ferroptosis and/or necroptosis. Our results broadened the understanding of MB-PDT-induced photooxidation mechanisms and specificity in breast cancer cells. Therefore, we demonstrated that efficient approaches could be designed on the basis of lipid composition and metabolic features for hard-to-treat cancers. The results further reinforce MB-PDT as a therapeutic strategy for highly aggressive human breast cancer cells.

scholarly journals Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells

2020 ◽  
Vol 11 (12) ◽  
Author(s):  
Ancély F. Dos Santos ◽  
Alex Inague ◽  
Gabriel S. Arini ◽  
Letícia F. Terra ◽  
Rosangela A. M. Wailemann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Molecular Mechanisms ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Photo Oxidation ◽  
Tumorigenic Cells

AbstractLack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using methylene blue as photosensitizer (MB-PDT) massively kills metastatic human breast cancer, marginally affecting healthy cells. In this study, we aimed to unveil the molecular mechanisms behind MB-PDT effectiveness and specificity towards tumor cells. Through lipidomics and biochemical approaches, we demonstrated that MB-PDT efficiency and specificity rely on polyunsaturated fatty acid-enriched membranes and on the better capacity to deal with photo-oxidative damage displayed by non-tumorigenic cells. We found out that, in tumorigenic cells, lysosome membrane permeabilization is accompanied by ferroptosis and/or necroptosis. Our results also pointed at a cross-talk between lysosome-dependent cell death (LDCD) and necroptosis induction after photo-oxidation, and contributed to broaden the understanding of MB-PDT-induced mechanisms and specificity in breast cancer cells. Therefore, we demonstrated that efficient approaches could be designed on the basis of lipid composition and metabolic features for hard-to-treat cancers. The results further reinforce MB-PDT as a therapeutic strategy for highly aggressive human breast cancer cells.

Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells

2011 ◽  
Vol 226 (7) ◽  
pp. 1741-1749 ◽  
Author(s):  
Marcia Godinho ◽  
Danielle Meijer ◽  
Buddy Setyono-Han ◽  
Lambert C.J. Dorssers ◽  
Ton van Agthoven
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Endocrine Resistance ◽  
Human Breast Cancer Cells ◽  
Human Breast
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