scholarly journals Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

2021 ◽  
pp. 101242
Author(s):  
Phil Pickford ◽  
Maria Lucey ◽  
Roxana-Maria Rujan ◽  
Emma Rose McGlone ◽  
Stavroula Bitsi ◽  
...  
Keyword(s):  
Partial Agonism

scholarly journals The dynamic role of regulator of G-protein signalling (RGS) proteins in partial agonism

2014 ◽  
Vol 592 (17) ◽  
pp. 3701-3702
Author(s):  
Joobin Sattar ◽  
Kevin P. Grace ◽  
Guillaume Bastin
Keyword(s):  
G Protein ◽  
Rgs Proteins ◽  
Partial Agonism ◽  
G Protein Signalling

scholarly journals Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156618 ◽  
Author(s):  
Moawiah M. Naffaa ◽  
Nathan Absalom ◽  
V. Raja Solomon ◽  
Mary Chebib ◽  
David E. Hibbs ◽  
...  
Keyword(s):  
Binding Site ◽  
Site Mutation ◽  
Partial Agonism ◽  
Gabac Receptors ◽  
Hydrophilic Residue

scholarly journals Mechanism of Cyclic AMP Partial Agonism in Protein Kinase G (PKG)

2016 ◽  
Vol 110 (3) ◽  
pp. 514a
Author(s):  
Bryan VanSchouwen ◽  
Rajeevan Selvaratnam ◽  
Rajanish Giri ◽  
Robin Lorenz ◽  
Friedrich W. Herberg ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Protein Kinase G ◽  
Partial Agonism

Revealing vilazodone's binding mechanism underlying its partial agonism to the 5-HT1A receptor in the treatment of major depressive disorder

2017 ◽  
Vol 19 (42) ◽  
pp. 28885-28896 ◽  
Author(s):  
Guoxun Zheng ◽  
Weiwei Xue ◽  
Fengyuan Yang ◽  
Yang Zhang ◽  
Yuzong Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Computational Methods ◽  
Binding Mode ◽  
Binding Mechanism ◽  
Major Depressive ◽  
Partial Agonism

The binding mechanism of vilazodone to 5-HT1A receptor was revealed via integrated computational methods. The identified binding mode will provide valuable information for medicinal chemists in designing and discovering novel SPARIs for MDD treatment.

The place of partial agonism in psychiatry: recent developments

2005 ◽  
Vol 19 (4) ◽  
pp. 408-413 ◽  
Author(s):  
R. I. Ohlsen ◽  
L. S. Pilowsky
Keyword(s):  
Partial Agonism ◽  
Recent Developments

Molecular determinants of PPARγ partial agonism and related in silico/in vivo studies of natural saponins as potential type 2 diabetes modulators

2018 ◽  
Vol 112 ◽  
pp. 47-59 ◽  
Author(s):  
Merilin Al Sharif ◽  
Petko Alov ◽  
Antonia Diukendjieva ◽  
Vessela Vitcheva ◽  
Rumyana Simeonova ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
In Silico ◽  
In Vivo Studies ◽  
Partial Agonism ◽  
Potential Type ◽  
Molecular Determinants
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