β-Cell pre-miR-21 Induces Dysfunction and Loss of Cellular Identity by Targeting Transforming Growth Factor Beta 2 (Tgfb2) and Smad Family Member 2 (Smad2) mRNAs

Molecular Metabolism ◽

10.1016/j.molmet.2021.101289 ◽

2021 ◽

pp. 101289

Author(s):

Sara Ibrahim ◽

Macey Johnson ◽

Clarissa Hernandez Stephens ◽

Jerry Xu ◽

Rachel Moore ◽

...

Keyword(s):

Growth Factor ◽

Family Member ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Β Cell ◽

Growth Factor Beta ◽

Beta 2 ◽

Cellular Identity

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Transforming Growth Factor Beta-2

10.32388/yvsf8o ◽

2020 ◽

Author(s):

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Growth Factor Beta ◽

Beta 2

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Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide.

Molecular Endocrinology ◽

10.1210/mend.6.5.1603080 ◽

1992 ◽

Vol 6 (5) ◽

pp. 694-702

Author(s):

D M Miller ◽

Y Ogawa ◽

K K Iwata ◽

P ten Dijke ◽

A F Purchio ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Growth Factor Beta ◽

Beta 2

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A novel 62-bp indel mutation in the promoter region of transforming growth factor-beta 2 (TGFB2) gene is associated with body weight in chickens

Animal Genetics ◽

10.1111/j.1365-2052.2010.02060.x ◽

2011 ◽

Vol 42 (1) ◽

pp. 108-112 ◽

Cited By ~ 13

Author(s):

S. Tang ◽

J. Ou ◽

D. Sun ◽

Y. Zhang ◽

G. Xu ◽

...

Keyword(s):

Body Weight ◽

Growth Factor ◽

Transforming Growth Factor Beta ◽

Promoter Region ◽

Transforming Growth Factor ◽

Indel Mutation ◽

Growth Factor Beta ◽

Beta 2

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Transforming growth factor-beta 2 heterozygous mutant mice exhibit Cowper's gland hyperplasia and cystic dilations of the gland ducts (Cowper's syringoceles)

Journal of Anatomy ◽

10.1046/j.1469-7580.2002.00079.x ◽

2002 ◽

Vol 201 (2) ◽

pp. 173-183 ◽

Cited By ~ 9

Author(s):

Nicole Dunker ◽

Gerhard Aumuller

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Mutant Mice ◽

Growth Factor Beta ◽

Beta 2

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Abstract 716: ASPH_0047: a potent and selective antisense oligonucleotide-targeting transforming growth factor beta 2 (TGF-β2)

10.1158/1538-7445.am2014-716 ◽

2014 ◽

Author(s):

Katja Wosikowski ◽

Frank Jaschinski ◽

Hanna Kohonen ◽

Stephan Braun ◽

Eugen Leo ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Antisense Oligonucleotide ◽

Transforming Growth Factor ◽

Growth Factor Beta ◽

Beta 2

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Serum transforming growth factor beta 2 and feeding intolerance in hydrolyzed protein formula-fed versus breast milk-fed preterm neonates

QJM ◽

10.1093/qjmed/hcy200.143 ◽

2018 ◽

Vol 111 (suppl_1) ◽

Author(s):

I S Abou Saif ◽

R I H Ismail ◽

W K Zaki ◽

A E R Aa Hamed

Keyword(s):

Growth Factor ◽

Breast Milk ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Preterm Neonates ◽

Feeding Intolerance ◽

Hydrolyzed Protein ◽

Growth Factor Beta ◽

Beta 2

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Maternal High Fat Diet Upregulates Transforming Growth Factor Beta 2 (TGF-²2) In The Rodent Lung

10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4146 ◽

2010 ◽

Author(s):

Pamela Hilvers ◽

Giovanni Piedimonte ◽

Lennie Samsell ◽

Cheryl Walton ◽

Mario Scuri

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

High Fat Diet ◽

Transforming Growth Factor ◽

High Fat ◽

Growth Factor Beta ◽

Beta 2

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Impact of targeting transforming growth factor β-2 with antisense OT-101 on the cytokine and chemokine profile in patients with advanced pancreatic cancer

OncoTargets and Therapy ◽

10.2147/ott.s161905 ◽

2018 ◽

Vol Volume 11 ◽

pp. 2779-2796 ◽

Cited By ~ 5

Author(s):

Osmond D'Cruz ◽

Sanjive Qazi ◽

Larn Hwang ◽

Kevin Ng ◽

Vuong Trieu

Keyword(s):

Pancreatic Cancer ◽

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Advanced Pancreatic Cancer ◽

Growth Factor Beta ◽

Beta 2

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Human uterine tissue throughout the menstrual cycle expresses transforming growth factor-beta 1 (TGF beta 1), TGF beta 2, TGF beta 3, and TGF beta type II receptor messenger ribonucleic acid and protein and contains [125I]TGF beta 1-binding sites.

Endocrinology ◽

10.1210/endo.135.1.8013382 ◽

1994 ◽

Vol 135 (1) ◽

pp. 439-449 ◽

Cited By ~ 51

Author(s):

N Chegini ◽

Y Zhao ◽

R S Williams ◽

K C Flanders

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Binding Sites ◽

Transforming Growth Factor ◽

Type Ii ◽

Tgf Beta ◽

Uterine Tissue ◽

Messenger Ribonucleic Acid ◽

Growth Factor Beta ◽

Beta 2

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Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.

Cell Regulation ◽

10.1091/mbc.1.1.87 ◽

1989 ◽

Vol 1 (1) ◽

pp. 87-97 ◽

Cited By ~ 202

Author(s):

A B Glick ◽

K C Flanders ◽

D Danielpour ◽

S H Yuspa ◽

M B Sporn

Keyword(s):

Retinoic Acid ◽

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Biologically Active ◽

Tgf Beta ◽

Mouse Epidermis ◽

Cultured Keratinocytes ◽

Growth Factor Beta ◽

Beta 2

We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.

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