Design and synthesis of imidazolo-1, 2,3-triazoles hybrid compounds by microwave-assisted method: Evaluation as an antioxidant and antimicrobial agents and molecular docking studies

2019 ◽  
Vol 1180 ◽  
pp. 618-628 ◽  
Author(s):  
N.J.P. Subhashini ◽  
E. Praveen Kumar ◽  
Nirmala Gurrapu ◽  
Vishwanadham Yerragunta
Keyword(s):  
Molecular Docking ◽  
Antimicrobial Agents ◽  
Docking Studies ◽  
Method Evaluation ◽  
Molecular Docking Studies ◽  
Design And Synthesis ◽  
Microwave Assisted ◽  
Hybrid Compounds ◽  
Microwave Assisted Method

Design and synthesis of new thiazoles by microwave-assisted method: Evaluation as an anti-breast cancer agents and molecular docking studies

2020 ◽  
Vol 50 (16) ◽  
pp. 2488-2501
Author(s):  
Srikanth Mamidala ◽  
V. Sushma Mudigunda ◽  
Sudhir Reddy Peddi ◽  
Kiran Kumar Bokara ◽  
Vijjulatha Manga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Docking ◽  
Docking Studies ◽  
Method Evaluation ◽  
Molecular Docking Studies ◽  
Design And Synthesis ◽  
Microwave Assisted ◽  
Microwave Assisted Method

scholarly journals Microwave-Assisted Synthesis, Molecular Docking Studies and Biological Evaluation of Benzothiazole Containing Novel Indole Derivatives

2021 ◽  
Vol 33 (11) ◽  
pp. 2755-2761
Author(s):  
Shaheen Sultana ◽  
P. Pandian ◽  
B. Rajkamal
Keyword(s):  
Molecular Docking ◽  
Reaction Mechanism ◽  
Anticancer Activity ◽  
Mannich Base ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Indole Derivatives ◽  
Standard Drug ◽  
Molecular Docking Studies ◽  
Microwave Assisted

The synthesis of novel indole derivatives 4a-o using a microwave assisted method via Schiff’s base and Mannich base reaction mechanism was described. Compounds 3a-c were synthesized via reaction of 2-amino benzothiazole with substituted isatin by Schiff base reaction mechanism. Also, indole derivatives 4a-o were synthesized via reaction of compounds 3a-c with substituted benzaldehydes by Mannich base reaction. The biological potentials of the newly synthesized indole derivatives were evaluated for their anthelmintic activity and in vitro anticancer activity by MTT assay. The anticancer activity results suggested that indole derivatives 4c-o have activity against MCF-7 and SKOV3 cells in comparison with doxorubicin as standard drug. Furthermore, the molecular docking studies of these novel derivatives of indole showed good agreement with the biological results when their binding pattern and affinity towards the active site of EGFR was also investigated.

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