Reprint of “DNA, the central molecule of aging”

2016 ◽  
Vol 788 ◽  
pp. 25-31 ◽  
Author(s):  
Peter Lenart ◽  
Lumir Krejci
Keyword(s):  
Central Molecule

Peptide Nucleic Acid (PNA). a Structural DNA Mimic

1993 ◽  
Vol 330 ◽  
Author(s):  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Linear Order ◽  
Genetic Information ◽  
Peptide Nucleic Acid ◽  
Deoxyribonucleic Acid ◽  
Chemical Constituent ◽  
Structural Role ◽  
Phosphate Backbone ◽  
Central Molecule

Deoxyribonucleic acid (DNA) may be regarded as the central molecule of life since it is the carrier of genetic information; it is the chemical constituent of the genes. DNA is a biopolymer composed of deoxyribonucleoside units connected via phosphodiester bridges (Figure 1a). It is the linear order of the nucleobases (A, C, G & T) that contain the genetic information, whereas the deoxyribose phosphate backbone primarily fulfils a structural role.

scholarly journals Biochemical Hypermedia: Glucose as a Central Molecule in Metabolism

2008 ◽  
Vol 6 (1) ◽  
pp. 12
Author(s):  
J.K. Sugai ◽  
R.V. Antônio ◽  
M.S.B. Figueiredo ◽  
D.N. Heidrich
Keyword(s):  
Central Molecule

Stability of molecular aggregates of hydrocarbons with all-trans chains and translation of the molecules

1985 ◽  
Vol 50 (7) ◽  
pp. 1553-1564 ◽  
Author(s):  
Ján Gajdoš ◽  
Tomáš Bleha
Keyword(s):  
Potential Energy ◽  
Interaction Potential ◽  
Conformational Transition ◽  
Molecular Aggregates ◽  
Hydrocarbon Chains ◽  
Central Molecule ◽  
The Matrix ◽  
Rotational Phase

Potential energy has been calculated for molecular aggregates formed of all-trans extended hexanes with various arrangements of the central molecule surrounded by the first coordination sphere. Differences in stabilities of the aggregates are connected with biaxial character of asymmetry of the interaction energy of extended paraffins. When investigating the multiparameter interaction potential of the partially ordered systems of hydrocarbon chains, the first step consisted in determination of the energy barriers to longitudinal shifts of the central molecules at various distances of the surrounding molecules. Destabilization of the aggregates with displaced molecules is due to both the mismatch of the central molecule to the matrix and effective shortening of that part of the central molecule which is "immersed" in the aggregate. The energetics of the model aggregates is made use of in elucidating the role of translation of paraffins and cognate molecules in rotational phase, in mesophases, and at a forced shortening of the chains connected with conformational transition.

scholarly journals A Scanning Tunneling Microscope as a Switch in a Nanocomputer

2008 ◽  
Vol 16 (5) ◽  
pp. 3-5
Author(s):  
Stephen W. Carmichael
Keyword(s):  
Scanning Tunneling Microscope ◽  
Molecular Machines ◽  
Atomic Level ◽  
Scanning Tunneling ◽  
Nanometer Scale ◽  
Tunneling Microscope ◽  
Central Molecule ◽  
Physical Forces ◽  
One Machine ◽  
Sharp Needle

There are several “molecular machines” that have been devised on a nanometer scale, made from proteins, DNA, and other molecules. A molecular machine is a system that generates physical forces at the atomic level, controlled by an external stimulus. Since all of the proposed circuits connect components linearly, they only communicate with one machine at a time. Now, Anirban Bandyopadhyay and Somobrata Acharya have devised an ingenious device that has the potential to communicate different instructions to many molecular machines simultaneously. They demonstrated that 2,3,5,6-tetramethyl-1–4-benzoquinone (duroquinone; DRQ) can be assembled as 17 identical molecules, one central molecule surrounded radially by 16 others. The central molecule can control the conformation of all the others when switched to one of four logic states by suitable pulses from an atomic sharp needle of a scanning tunneling microscope (STM).

A stochastic model of fragment formation when DNA replicates

1994 ◽  
Vol 31 (2) ◽  
pp. 301-308 ◽  
Author(s):  
Richard Cowan ◽  
S. N. Chiu
Keyword(s):  
Stochastic Model ◽  
Unique Property ◽  
Single Strand ◽  
Central Problem ◽  
Okazaki Fragments ◽  
Central Molecule ◽  
Fragment Formation ◽  
The Mean ◽  
Key Sites ◽  
Random Location

The double-stranded molecule, DNA, has the unique property of replication and, because of this, it is the central molecule of life. The mechanism of replication for each single strand is intricate, involving enzymes which move along each of the single strands building a complementary copy. At the frontier of this action, the events have a strong stochastic character due to the random location on the DNA of key ‘sites' where copying commences. A model of this process is analysed. The central problem of interest is the mean length of certain ‘islands' of newly replicated DNA developed at the randomly located ‘sites'. These islands, which have been observed experimentally, are called Okazaki fragments.

Excess around a central molecule with application to binary mixtures

2008 ◽  
Vol 10 (8) ◽  
pp. 1097-1105 ◽  
Author(s):  
Ivan L. Shulgin ◽  
Eli Ruckenstein
Keyword(s):  
Binary Mixtures ◽  
Central Molecule

scholarly journals Energetics competition in centrally four-coordinated water clusters and Raman spectroscopic signature for hydrogen bonding

RSC Advances ◽  
2017 ◽  
Vol 7 (19) ◽  
pp. 11680-11683 ◽  
Author(s):  
Bo Wang ◽  
Wanrun Jiang ◽  
Yang Gao ◽  
Zhiyuan Zhang ◽  
Changqing Sun ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Water Clusters ◽  
Water Molecules ◽  
Raman Spectroscopic ◽  
Central Molecule ◽  
Coordinated Water

Viaseparating the H-bonded neighbour molecules of centrally four-coordinated water molecules from other molecules in outer cages, the calculations discover these two regions interact competitively with the central molecule.

A new method of solving the Born-Green equation for the radial distribution function

1952 ◽  
Vol 210 (1103) ◽  
pp. 509-517 ◽  
Keyword(s):  
Distribution Function ◽  
Radial Distribution Function ◽  
Numerical Integration ◽  
Potential Function ◽  
Radial Distribution ◽  
Lennard Jones Potential ◽  
Jones Potential ◽  
Lennard Jones ◽  
Central Molecule ◽  
Close Range

A solution of the Born-Green equation for the radial distribution function may be found as a series in ascending powers of the density. This method is applied to a fluid of rigid spherical molecules, and the results are compared with those which Kirkwood, Maun & Alder obtained by means of numerical integration. For such molecules it is possible to show that the close-range structure at a distance between n and n + 1 diameters from a central molecule is of the order of the density raised to the n th power ( n integral). When the Lennard-Jones potential function is employed, the first and second approximations to the radial distribution function thus obtained are shown to be identical with those resulting from a rigorous development of this function in powers of the density.

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