Peptide Nucleic Acid (PNA). a Structural DNA Mimic

1993 ◽  
Vol 330 ◽  
Author(s):  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Linear Order ◽  
Genetic Information ◽  
Peptide Nucleic Acid ◽  
Deoxyribonucleic Acid ◽  
Chemical Constituent ◽  
Structural Role ◽  
Phosphate Backbone ◽  
Central Molecule

Deoxyribonucleic acid (DNA) may be regarded as the central molecule of life since it is the carrier of genetic information; it is the chemical constituent of the genes. DNA is a biopolymer composed of deoxyribonucleoside units connected via phosphodiester bridges (Figure 1a). It is the linear order of the nucleobases (A, C, G & T) that contain the genetic information, whereas the deoxyribose phosphate backbone primarily fulfils a structural role.

PNA-nucleic acid complexes. Structure, stability and dynamics

1996 ◽  
Vol 29 (4) ◽  
pp. 369-394 ◽  
Author(s):  
Magdalena Eriksson ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Hydrolytic Enzymes ◽  
Living Cells ◽  
Structure Stability ◽  
Peptide Chemistry ◽  
Cell Extracts ◽  
Phosphate Backbone ◽  
A Chain ◽  
Nucleic Acid Analogues

Growing interest in gene targeting drugs has inspired the development of a multitude of nucleic acid analogues, many of which feature substitutions in the phosphodiester moiety of the backbone (reviewed by Mesmaeker et al. 1995 and Nielsen, 1995). Peptide nucleic acid (PNA) is an example of a more radical redesign of DNA. The entire sugar-phosphate backbone is substituted by a chain of peptide-like N-(2-aminoethyl)glycine units so that an achiral and uncharged DNA-mimic is obtained (Fig. 1; Nielsen et al. 1991). The synthesis is based on standard peptide chemistry (Christensen et al. 1995) and has been automated. PNA can relatively easily be modified to include modifications of the backbone as well as of the bases (Hyrup & Nielsen, 1996). PNA is chemically stable and, in contrast to natural nucleic acids and peptides, PNA is expected to remain intact in living cells since it is not a substrate for natural hydrolytic enzymes and is not degraded by cell extracts (Demidov et al. 1994).

Hydrogen-Bonding Interactions in Peptide Nucleic Acid and Deoxyribonucleic Acid:  A Comparative Study

2006 ◽  
Vol 110 (7) ◽  
pp. 3336-3343 ◽  
Author(s):  
Holly Elizabeth Herbert ◽  
Mathew D. Halls ◽  
Hrant P. Hratchian ◽  
Krishnan Raghavachari
Keyword(s):  
Hydrogen Bonding ◽  
Nucleic Acid ◽  
Comparative Study ◽  
Peptide Nucleic Acid ◽  
Deoxyribonucleic Acid ◽  
Hydrogen Bonding Interactions

Application of peptide nucleic acid to the direct detection of deoxyribonucleic acid amplified by polymerase chain reaction

1999 ◽  
Vol 14 (4) ◽  
pp. 397-404 ◽  
Author(s):  
Shinya Sawata ◽  
Eriko Kai ◽  
Kazunori Ikebukuro ◽  
Tetsuya Iida ◽  
Takeshi Honda ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Deoxyribonucleic Acid ◽  
Direct Detection ◽  
Chain Reaction ◽  
Polymerase Chain

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

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