Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers

2008 ◽  
Vol 649 (1-2) ◽  
pp. 221-229 ◽  
Author(s):  
X. Yang ◽  
J. Yuan ◽  
J. Sun ◽  
H. Wang ◽  
H. Liang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Peripheral Blood ◽  
Heat Shock Protein 70 ◽  
Gene Polymorphisms ◽  
Coke Oven ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Coke Oven Workers

Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis

1999 ◽  
Vol 27 (6) ◽  
pp. 1080-1084 ◽  
Author(s):  
Stefan Schroeder ◽  
Carsten Lindemann ◽  
Andreas Hoeft ◽  
Christian Putensen ◽  
Dorothee Decker ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Peripheral Blood ◽  
Heat Shock Protein 70 ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

Interaction of heat shock protein 70 (HSP70) polymorphisms and occupational hazards increases the risk of hypertension in coke oven workers

2018 ◽  
Vol 75 (11) ◽  
pp. 807-813 ◽  
Author(s):  
Jin-Ping Zheng ◽  
Yi Lyu ◽  
Rui-fang Li ◽  
Feng-jie Tian ◽  
Jian-bing Mu
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Epigenetic Inheritance ◽  
Coke Oven ◽  
Northwest China ◽  
Occupational Hazards ◽  
Positive Interaction ◽  
Occupational Environment ◽  
Coke Oven Workers

ObjectivesThe interaction between genetic, epigenetic inheritance and environmental factors determines susceptibility to hypertension. Previous epidemiology studies have shown that coke oven workers who are frequently exposed to various occupational hazards have remarkable increase in the risk for hypertension. Among many genetic variants identified in hypertension, heat shock protein 70 (HSP70) was found to play important roles in the pathogenesis of hypertension and associated diseases. We therefore explore the possible role of HSP70 polymorphisms and their interaction with occupational environment in hypertension risk.MethodsWe carried out a case–control study among 367 coke oven workers in northwest China, focused on three common HSP70 polymorphisms (HSP70-1 G190C, HSP70-2 A1267G and HSP70-hom T2437C), and evaluated the association of HSP70 gene polymorphisms with work sites for high risk of hypertension.ResultsThe results indicated that HSP70-1 GC and CC genotype had 2.73-fold and 4.26-fold increased relative risk (95% CI 1.33 to 5.55 and 1.17 to 15.53), respectively, comparing with HSP70-1 GG genotype. HSP70-2 AG and GG conferred a 47% and 36% reduced risk (95% CI 0.23 to 0.99 and 0.14 to 0.92) comparing with HSP70-2 AA genotype. Further analysis of the interaction of HSP70 polymorphisms with occupational environment indicated a strong positive interaction between HSP70 genotype (HSP70-1 GC+CC, HSP70-2 AA and HSP70-hom TC+CC) and oven top workplace.ConclusionsCollectively, these data indicate that HSP70 polymorphisms interact with occupational hazards might increase the risk of hypertension in coke oven workers.

scholarly journals Influence of dietary fish oil supplementation on DNA damage in peripheral blood lymphocytes of nine healthy dogs

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Francisco J. Pellegrino ◽  
Analía Risso ◽  
Yanina Corrada ◽  
Rocío C. Gambaro ◽  
Analía I. Seoane
Keyword(s):  
Dna Damage ◽  
Fish Oil ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Dietary Fish ◽  
Healthy Dogs ◽  
Fish Oil Supplementation

scholarly journals Analysis of 177Lu-DOTA-Octreotate Therapy-Induced DNA Damage in Peripheral Blood Lymphocytes of Patients with Neuroendocrine Tumors

2015 ◽  
Vol 56 (4) ◽  
pp. 505-511 ◽  
Author(s):  
D. Denoyer ◽  
P. Lobachevsky ◽  
P. Jackson ◽  
M. Thompson ◽  
O. A. Martin ◽  
...  
Keyword(s):  
Dna Damage ◽  
Neuroendocrine Tumors ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes
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