scholarly journals Influence of dietary fish oil supplementation on DNA damage in peripheral blood lymphocytes of nine healthy dogs

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Francisco J. Pellegrino ◽  
Analía Risso ◽  
Yanina Corrada ◽  
Rocío C. Gambaro ◽  
Analía I. Seoane
Keyword(s):  
Dna Damage ◽  
Fish Oil ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Dietary Fish ◽  
Healthy Dogs ◽  
Fish Oil Supplementation

scholarly journals Analysis of 177Lu-DOTA-Octreotate Therapy-Induced DNA Damage in Peripheral Blood Lymphocytes of Patients with Neuroendocrine Tumors

2015 ◽  
Vol 56 (4) ◽  
pp. 505-511 ◽  
Author(s):  
D. Denoyer ◽  
P. Lobachevsky ◽  
P. Jackson ◽  
M. Thompson ◽  
O. A. Martin ◽  
...  
Keyword(s):  
Dna Damage ◽  
Neuroendocrine Tumors ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals SMOKING GENOTOXICITY IN PERIPHERAL BLOOD LYMPHOCYTES USING THE COMET ASSAY

2013 ◽  
Vol 03 (03) ◽  
pp. 038-041
Author(s):  
Shobha S. Shetty ◽  
Hrishikesh Nachane
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
The Body ◽  
P Value ◽  
Tail Moment ◽  
Blood Lymphocytes ◽  
Significant Difference ◽  
Almost All

Abstract Background: Smoking has been shown to have a positive effect on DNA damage in almost all the cells of the body. Quantitative analysis of this damage will help in assessing the etiopathogenesis of various nicotine induced damage to the body. Comet assay has been an emerging tool in this regard and hence was applied by us to estimate the severity of DNA damage in smokers. Aims & Objectives: To evaluate the DNA genotoxicity in peripheral blood lymphocytes in smokers and their comparison with non smokers & assess the quantitative damage. Materials and methods: 30 smokers & 20 non smokers were recruited & their peripheral blood was taken for the comet assay to look for Olive moment & Tail moment to quantitatively assess the DNA damage due to cigarette smoking. Results: In our study there was no significant difference in the analysis of DNA damage (with regard to tail moment & olive moment) in smokers versus non smokers (P value: more than 0.05). Conclusions: Though smoking is known to cause DNA damage, we did not find significant differences between the two groups probably due to other multifactorial etiologies for genotoxicity.

Biomonitoring of DNA damage in peripheral blood lymphocytes of subjects with dental restorative fillings

2008 ◽  
Vol 650 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Angela Di Pietro ◽  
Giuseppa Visalli ◽  
Sebastiano La Maestra ◽  
Rosanna Micale ◽  
Barbara Baluce ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Dental Restorative

scholarly journals Evaluation of Genotoxic and Cytotoxic Effects in Human Peripheral Blood Lymphocytes ExposedIn Vitroto Neonicotinoid Insecticides News

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
María Elena Calderón-Segura ◽  
Sandra Gómez-Arroyo ◽  
Rafael Villalobos-Pietrini ◽  
Carmen Martínez-Valenzuela ◽  
Yolanda Carbajal-López ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blue Dye ◽  
Cytotoxic Effects ◽  
Blood Lymphocytes ◽  
Neonicotinoid Insecticides ◽  
Human Peripheral Blood Lymphocytes

Calypso (thiacloprid), Poncho (clothianidin), Gaucho (imidacloprid), and Jade (imidacloprid) are commercial neonicotinoid insecticides, a new class of agrochemicals in México. However, genotoxic and cytotoxic studies have not been performed. In the present study, human peripheral blood lymphocytes (PBL) were exposedin vitroto different concentrations of the four insecticides. The genotoxic and cytotoxic effects were evaluated using the alkaline comet and trypan blue dye exclusion assays. DNA damage was evaluated using two genotoxicity parameters: tail length and comet frequency. Exposure to9.5×10-6to5.7×10-5 M Jade;2.8×10-4to1.7×10-3 M Gaucho;0.6×10-1to1.4×10-1 M Calypso;1.2×10-1to9.5×10-1 M Poncho for 2 h induced a significant increase DNA damage with a concentration-dependent relationship. Jade was the most genotoxic of the four insecticides studied. Cytotoxicity was observed in cells exposed to18×10-3 M Jade,2.0×10-3 M Gaucho,2.0×10-1 M Calypso, 1.07 M Poncho, and cell death occurred at30×10-3 M Jade,3.3×10-3 M Gaucho,2.8×10-1 M Calypso, and 1.42 M Poncho. This study provides the first report of genotoxic and cytotoxic effects in PBL followingin vitroexposure to commercial neonicotinoid insecticides.

Occult HCV Elicits Oxidative Stress and Triggers PI3 Kinase Mediated DNA Damage Response in Peripheral Blood Lymphocytes

2012 ◽  
Vol 107 ◽  
pp. S144
Author(s):  
Subodh Varshney ◽  
Pradyumna Mishra ◽  
Ajit Sewkani ◽  
Sachin Gupta ◽  
A. Bhargava ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Pi3 Kinase ◽  
Blood Lymphocytes ◽  
Damage Response

scholarly journals The Immunophenotype of Peripheral Blood Lymphocytes in Clinically Healthy Dogs and Dogs with Lymphoma in Remission

2005 ◽  
Vol 19 (2) ◽  
pp. 193-199 ◽  
Author(s):  
M.J. Gauthier ◽  
I. Aubert ◽  
A. Abrams-Ogg ◽  
J.P. Woods ◽  
D. Bienzle
Keyword(s):  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Healthy Dogs

Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: With the comparison of N-acetylcysteine

Toxicology ◽  
2007 ◽  
Vol 230 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Adluri Ram Sudheer ◽  
Shanmugavelu Muthukumaran ◽  
Nagarajan Devipriya ◽  
Venugopal Padmanabhan Menon
Keyword(s):  
Dna Damage ◽  
Ellagic Acid ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Natural Polyphenol
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