Genomic instability in peripheral blood lymphocytes of patients diagnosed with high-grade squamous intraepithelial lesions: CIN 2 versus CIN 3

2020 ◽  
Vol 854-855 ◽  
pp. 503202
Author(s):  
Goneta Gashi ◽  
Elton Bahtiri ◽  
Arjeta Podrimaj-Bytyqi ◽  
Luan Morina ◽  
Luljeta Gashi ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Blood Lymphocytes ◽  
Intraepithelial Lesions

scholarly journals Chromosome Aberrations as a Biomarker for Genomic Instability in Cell Cultures Originated From Bovines, Canines and Equines Infected With Papillomavirus

2016 ◽  
Vol 4 (1) ◽  
pp. 104-112
Author(s):  
Rachel Siqueira de Queiroz Simões ◽  
Ortrud Monika Barth
Keyword(s):  
Genomic Instability ◽  
Cell Cultures ◽  
Peripheral Blood ◽  
Chromosomal Abnormalities ◽  
Cytogenetic Study ◽  
Peripheral Blood Lymphocytes ◽  
Chromosome Condensation ◽  
Premature Chromosome Condensation ◽  
Blood Lymphocytes ◽  
First Time

Chromosomal abnormalities or aberrations were investigated in ten bovines, three canines and three equines presenting cutaneous papillomatosis. The aim of the present study was to evaluate possible chromosomal abnormalities as a biomarker of genomic instability induced by the interaction of the viral genome with the chromatin of the host cell in peripheral blood lymphocytes and skin warts lesion cultures. Genomic DNA was extracted from blood samples and epithelial biopsies. Amplification products from PCR using degenerated primer pair FAP59/FAP64 were sequenced. Peripheral blood lymphocytes and tumor cell cultures were performed. Structural chromosomal aberrations were verified as associations, chromosomal fragments, centric fusions, open chromatids, gaps, rearrangements and rings. Several levels of premature chromosome condensation were observed in both cultures. Numeric abnormalities as aneuploidy were also detected and hipoployd cells were found in a larger number than the hiperployd cells. This cytogenetic study in detecting premature chromosome condensation in the three species investigated describes by the first time the structural and numerical abnormalities in canines and equines presenting papillomatosis lesions. These abnormalities are similar of the three groups of animals, but virus specific.Int J Appl Sci Biotechnol, Vol 4(1): 104-112

scholarly journals Persistent genomic instability in peripheral blood lymphocytes from hodgkin lymphoma survivors

2012 ◽  
Vol 53 (4) ◽  
pp. 271-280 ◽  
Author(s):  
C. Salas ◽  
A. Niembro ◽  
V. Lozano ◽  
E. Gallardo ◽  
B. Molina ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Genomic Instability ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Lymphoma Survivors

scholarly journals Genomic instability and cellular stress in organ biopsies and peripheral blood lymphocytes from patients with colorectal cancer and predisposing pathologies

Oncotarget ◽  
2015 ◽  
Vol 6 (17) ◽  
pp. 14852-14864 ◽  
Author(s):  
Sara Lombardi ◽  
Ilenia Fuoco ◽  
Giorgia di Fluri ◽  
Francesco Costa ◽  
Angelo Ricchiuti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genomic Instability ◽  
Peripheral Blood ◽  
Cellular Stress ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals Peripheral Blood Lymphocytes as In Vitro Model to Evaluate Genomic Instability Caused by Low Dose Radiation

2016 ◽  
Vol 17 (4) ◽  
pp. 1773-1777 ◽  
Author(s):  
Shikha Tewari ◽  
Kainat Khan ◽  
Nuzhat Husain ◽  
Madhup Rastogi ◽  
Surendra P Mishra ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Peripheral Blood ◽  
In Vitro Model ◽  
Low Dose ◽  
Peripheral Blood Lymphocytes ◽  
Low Dose Radiation ◽  
Blood Lymphocytes ◽  
Vitro Model ◽  
Dose Radiation
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