scholarly journals Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesis

2021 ◽  
Vol 787 ◽  
pp. 108376
Author(s):  
Rahaba Marima ◽  
Rodney Hull ◽  
Clement Penny ◽  
Zodwa Dlamini
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Aurora Kinase ◽  
Mitotic Arrest ◽  
Aurora Kinase B ◽  
Damage Response

scholarly journals Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Karolina O. Hain ◽  
Didier J. Colin ◽  
Shubhra Rastogi ◽  
Lindsey A. Allan ◽  
Paul R. Clarke
Keyword(s):  
Dna Damage ◽  
Cell Survival ◽  
Dna Damage Response ◽  
Mitotic Arrest ◽  
Damage Response

scholarly journals AURKB/Ipl1 restarts replication forks to recover from replication stress.

2021 ◽  
Author(s):  
Erin Moran ◽  
Katherine E Pfister ◽  
Kizhakke Mattada Sathyan ◽  
Brianne Vignero ◽  
Daniel J Burke ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Dna Damage Response ◽  
Chromosome Instability ◽  
Replication Stress ◽  
Aurora Kinase ◽  
S Phase ◽  
Replication Forks ◽  
Aurora Kinase B ◽  
Dna Damaging Agents ◽  
Damage Response

Aurora kinase B (AURKB in human, Ipl1 in S. cerevisiae) is a master regulator of mitosis and its dysregulation has been implicated in chromosome instability. AURKB accumulates in the nucleus in S-phase and is regulated by CHK1 but has not been implicated in in the DNA Damage Response (DDR). Here we show that AURKB has a conserved role to recover from replication stress and restart replication forks. Active AURKB is localized to replication forks after a prolonged arrest. CHK1 phosphorylation of AURKB induces activating phosphorylation of PLK1 and both Aurora and Plk1 are required to deactivate the DDR. Clinical trials with AURKB inhibitors are designed to target established roles for AURKB in mitosis. Our data suggest combinations of AURKB inhibitors and DNA damaging agents could be of therapeutic importance.

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response
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